ID Q8X5I9_ECO57 Unreviewed; 513 AA.
AC Q8X5I9; A0A0H3JFV6; A0A6M0JJJ9; Q7AH39;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 174.
DE SubName: Full=Sensor histidine protein kinase {ECO:0000313|EMBL:BAB33840.1};
GN ORFNames=ECs_0417 {ECO:0000313|EMBL:BAB33840.1};
OS Escherichia coli O157:H7.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334 {ECO:0000313|EMBL:BAB33840.1, ECO:0000313|Proteomes:UP000000558};
RN [1] {ECO:0000313|EMBL:BAB33840.1, ECO:0000313|Proteomes:UP000000558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC {ECO:0000313|Proteomes:UP000000558};
RX PubMed=11258796; DOI=.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BA000007; BAB33840.1; -; Genomic_DNA.
DR RefSeq; NP_308444.1; NC_002695.1.
DR RefSeq; WP_000089287.1; NZ_VOAI01000005.1.
DR AlphaFoldDB; Q8X5I9; -.
DR SMR; Q8X5I9; -.
DR DIP; DIP-60133N; -.
DR STRING; 155864.Z0462; -.
DR GeneID; 914519; -.
DR KEGG; ecs:ECs_0417; -.
DR PATRIC; fig|386585.9.peg.512; -.
DR eggNOG; COG3851; Bacteria.
DR HOGENOM; CLU_041023_0_0_6; -.
DR OMA; PNVFMAY; -.
DR Proteomes; UP000000558; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR007895; MASE1.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF37; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE_PHOSPHATASE UHPB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF05231; MASE1; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAB33840.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000558};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
SQ SEQUENCE 513 AA; 57988 MW; 31FE2D7A87630F07 CRC64;
MSRNLRHWVI LLFIVLAWGT GWLMLWTLSF YLTNNGQQAV LFLPQGVYLA LVILLSRRYW
PALVLPPLLM MFWLHSEQLL NGYLMLATPV ISLFPALLAQ NFWHRFPLYW QRLTLLLATV
TAASLLNTAL LSPFMSGPIM LPGLTSFTGG VLLTPFVYLI FEFLRQQHRY QLLGLDTHNP
PLRTSLIIWC SLFFIIGIGT QMVLSPEIER LLLIVVFLPN VVMAWKFGWQ GGVLSGLLGS
MMITIARQIG VGFSNLVELE IFLATQALLG IGLGIAISRQ QHLALNLHHY RQRLEAELAA
RRALAEKLIH TEEDTRKNLA RELHDEIGQN ITAIQIQSQL VKRARDPAQI QSAASQINEL
ARRIHLSTRQ LLRQLRPPAL DELTFREALL HLINEFAFSE RGIHCQFAYQ LNSTPENETV
RFTLYRLLQE LLNNICKHAE ASEVTIILRQ QGEVLHLEVS DNGVGIASGK MAGFGIQGMR
ERVSALGGDL TLEKQHGTRV IVNLPTFLQQ IAG
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