ID Q8YNI6_NOSS1 Unreviewed; 756 AA.
AC Q8YNI6;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN OrderedLocusNames=alr4579 {ECO:0000313|EMBL:BAB76278.1};
OS Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=103690 {ECO:0000313|EMBL:BAB76278.1, ECO:0000313|Proteomes:UP000002483};
RN [1] {ECO:0000313|EMBL:BAB76278.1, ECO:0000313|Proteomes:UP000002483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576
RC {ECO:0000313|Proteomes:UP000002483};
RX PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; BA000019; BAB76278.1; -; Genomic_DNA.
DR PIR; AC2378; AC2378.
DR RefSeq; WP_010998711.1; NZ_RSCN01000007.1.
DR AlphaFoldDB; Q8YNI6; -.
DR STRING; 103690.gene:10496629; -.
DR CAZy; GT51; Glycosyltransferase Family 51.
DR KEGG; ana:alr4579; -.
DR eggNOG; COG0744; Bacteria.
DR eggNOG; COG1716; Bacteria.
DR OrthoDB; 499624at2; -.
DR Proteomes; UP000002483; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002483}.
FT DOMAIN 64..118
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
SQ SEQUENCE 756 AA; 82742 MW; D03CD889B0B12DEE CRC64;
MNSPQPPHKP QTLLGQLTQA VNTIQARVDF SKLALKPNAK VPELWVQDAG ADKAEVYPLL
GDRYVLGRSS KSSDIVIRNP VVSQIHLSLS RDSSQRTPVF IIKDENSTNG IYRGKRRVNT
LELRHGDILT LGPPELAASV RLQYVDPPPW YIKAATWAGY GVGGASALLA LVIGVEWLKF
SVRPLPTTTR APVVVYARDG STPLREPRTV SHVDMKRLED FGPYLAAAVV ASEDSRFNWH
FGVDPLGILR AVLINTRSGD VQQGASTITQ QVSRSLFRDY VGRQDSLGRK LREAIVSLKL
EAFYSKDEVL LMYLNRVFLG ADTSGFEDAA QFYFDKPAKE LTLAEAATLV GILPAPNAFD
FCGSGPNKLE AADYRNRVVK RMLEMGKVTP EEANRARRST VQVSPKVCEQ QAKTIAPYFY
NYVFQELEAI LGEGAAREGN YIIETQLDPA IQAQAETALR NSVSTAGSTF RFSQGAMVTL
DSRTGSILAM VGGRDYRTSQ FNRAVQAKRQ PGSTFKIFAY AQALLQGIPA SRTYSCAPLT
WQGFTYRPCR SGAGVNMDVA TGLALSENPV ALRIAREVGL DKVVSMAQRL GVKSQLDAVP
GLVLGQSVVN VLEMTGAFGA ISNRGVWNPP HAINRILDSS DCSDRNDLKT CRVIYSFDSD
REANKRVLPQ PIADQMTDLM QAVITRGTGR SAAIGLGEAG KTGTTDKNVD LWFIGFIPNR
RLVTGIWLGN DDNSPTSGSS AQAAQLWGNY MRRITR
//
