ID Q8ZPW4_SALTY Unreviewed; 497 AA.
AC Q8ZPW4;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=diguanylate cyclase {ECO:0000256|ARBA:ARBA00012528};
DE EC=2.7.7.65 {ECO:0000256|ARBA:ARBA00012528};
GN Name=yeaJ {ECO:0000313|EMBL:AAL20208.1};
GN OrderedLocusNames=STM1283 {ECO:0000313|EMBL:AAL20208.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL20208.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL20208.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 GTP = 3',3'-c-di-GMP + 2 diphosphate; Xref=Rhea:RHEA:24898,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58805; EC=2.7.7.65;
CC Evidence={ECO:0000256|ARBA:ARBA00034247};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Purine metabolism; 3',5'-cyclic di-GMP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004665}.
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DR EMBL; AE006468; AAL20208.1; -; Genomic_DNA.
DR RefSeq; NP_460249.1; NC_003197.2.
DR RefSeq; WP_001048646.1; NC_003197.2.
DR AlphaFoldDB; Q8ZPW4; -.
DR STRING; 99287.STM1283; -.
DR PaxDb; 99287-STM1283; -.
DR GeneID; 1252801; -.
DR KEGG; stm:STM1283; -.
DR PATRIC; fig|99287.12.peg.1364; -.
DR HOGENOM; CLU_042022_1_0_6; -.
DR OMA; EFCVILI; -.
DR PhylomeDB; Q8ZPW4; -.
DR BioCyc; SENT99287:STM1283-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0052621; F:diguanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IBA:GO_Central.
DR GO; GO:1902201; P:negative regulation of bacterial-type flagellum-dependent cell motility; IBA:GO_Central.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR049828; DgcJ_diguan.
DR InterPro; IPR033420; GAPES1.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; NF040885; diguan_DgcJ; 1.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF22; DIGUANYLATE CYCLASE DGCJ-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF17155; GAPES1; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 374..497
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 497 AA; 56980 MW; A4456EBD318E7206 CRC64;
MNLHHKALRH FISASVIVLT SSFLIYELIA SDRAMNAYMR YIMERADSSF LYDKYQNQSI
AAHLMRTFEA PGDPVTAEKH RAFCDAFEAI NGTHGVNLTR HNYPALHGTL QTAATQCTDN
LDDALLLPAF DQAVSINRSQ DDHSHGLGTL ELKFRYYVDL NKHYVYFYDL INSRRFAMHR
WTFLQKGTMG INRKDIDKLF TGRTVISSIY MDDITQENVM SFLTPVYLAG SLKGIVMVDV
NQDNLKNIFY TQDRPLVWRY LNVTLKDMDS GKEIIINQSK NNLFQYVNYS HDIPGGLRVS
LSLDLTYFLV SSWKALAFYL LATALLLNMV RMHFRLYRNV TRENISDAMT GLYNRKILTP
VLEQRLQRLV NTGTPVTFVA IDCDRLKLIN DTQGHQEGDR IITLLAKAIK TSIRKSDYAI
RLGGDEFCII LVDYAADLAI HLPERIIRNL QIIAPDKTVH FSAGIYNMQP NDTINDAYQA
SDAQLYLNKQ QKQHRSS
//
