ID Q8ZRN7_SALTY Unreviewed; 713 AA.
AC Q8ZRN7;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Lysine decarboxylase 2, constitutive {ECO:0000313|EMBL:AAL19198.1};
DE EC=4.1.1.18 {ECO:0000313|EMBL:AAL19198.1};
GN Name=ldcC {ECO:0000313|EMBL:AAL19198.1};
GN OrderedLocusNames=STM0234 {ECO:0000313|EMBL:AAL19198.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL19198.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL19198.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-I family.
CC {ECO:0000256|ARBA:ARBA00010671}.
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DR EMBL; AE006468; AAL19198.1; -; Genomic_DNA.
DR RefSeq; NP_459239.1; NC_003197.2.
DR RefSeq; WP_001021054.1; NC_003197.2.
DR AlphaFoldDB; Q8ZRN7; -.
DR STRING; 99287.STM0234; -.
DR PaxDb; 99287-STM0234; -.
DR GeneID; 1251752; -.
DR KEGG; stm:STM0234; -.
DR PATRIC; fig|99287.12.peg.247; -.
DR HOGENOM; CLU_014292_3_0_6; -.
DR OMA; MMEAPGG; -.
DR PhylomeDB; Q8ZRN7; -.
DR BioCyc; SENT99287:STM0234-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008923; F:lysine decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR CDD; cd00615; Orn_deC_like; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.90.100.10; Orn/Lys/Arg decarboxylase, C-terminal domain; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR005308; OKR_de-COase_N.
DR InterPro; IPR011193; Orn/lys/arg_de-COase.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR008286; Prn/Lys/Arg_de-COase_C.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR45229:SF3; BIODEGRADATIVE ARGININE DECARBOXYLASE; 1.
DR PANTHER; PTHR45229; CONSTITUTIVE ORNITHINE DECARBOXYLASE; 1.
DR Pfam; PF01276; OKR_DC_1; 1.
DR Pfam; PF03711; OKR_DC_1_C; 1.
DR Pfam; PF03709; OKR_DC_1_N; 1.
DR PIRSF; PIRSF009393; Orn_decarb; 1.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00703; OKR_DC_1; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AAL19198.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR009393-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014}.
FT DOMAIN 362..376
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|PROSITE:PS00703"
FT MOD_RES 367
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR009393-1"
SQ SEQUENCE 713 AA; 80763 MW; 6CF351B948D217EB CRC64;
MNIIAIMGPH GVYYKDEPIK ELERALQSLG FQIIWPQNSV DLLKFIEHNP RICGVIFDWD
EYSLDLCSEI NQLNEYLPLY AFINTNSTLD VSVHDMRMAL WFFEYALGLA EDIATRIHQY
TNEYLDNITP PFTKALFTYA KEGKYTFCTP GHMAGTAYQK SPPGCLFYDF FGGNTLKADV
SISVTELGSL LDHTGPHLEA EEYIARTFGA EQSYMVTNGT STSNKIVGMY AAPAGSTLLI
DRNCHKSLAH LLMMSDVVPL WLKPTRNALG ILGGIPRREF TRASIESKIE ETPQAQWPVH
AVITNSTYDG LLYNTNWIKQ MLDVPSIHFD SAWVPYTHFH PIYQGKSGMS GDRVPGKVIF
ETQSTHKMLA AFSQASLIHI KGEYDEETFN EAFMMHTSTS PSYPIVASIE TAAAMLRGNP
GKRLINRSVE RALHFRKEVQ RLREESDSWF FDIWQPEEVD EAECWPVTPG ETWHGFTDAD
DDHMFLDPVK VTILTPGMDE QGNMSEEGIP AALVAKFLDE RGVVVEKTGP YNLLFLFSIG
IDKTRAMGLL RGLTEFKRAY DLNLRVKNML PDLYAEDPDF YRNMRIQDLA QGIHKLIRQH
DLPGLMLRAF EVLPEMIMTP HQAWQRQIKG EVETVALDQL PGRVSANMIL PYPPGVPLLM
PGERITQQSR AVLDFLLMLC SIGQHYPGFE TDIHGAKRNE DGVYQVRVLK HAC
//
