ID Q8ZWN5_PYRAE Unreviewed; 502 AA.
AC Q8ZWN5;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Peptidase M50 domain-containing protein {ECO:0000259|Pfam:PF02163};
GN OrderedLocusNames=PAE1702 {ECO:0000313|EMBL:AAL63665.1};
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306 {ECO:0000313|EMBL:AAL63665.1, ECO:0000313|Proteomes:UP000002439};
RN [1] {ECO:0000313|EMBL:AAL63665.1, ECO:0000313|Proteomes:UP000002439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 /
RC IM2 {ECO:0000313|Proteomes:UP000002439};
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE009441; AAL63665.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZWN5; -.
DR STRING; 178306.PAE1702; -.
DR EnsemblBacteria; AAL63665; AAL63665; PAE1702.
DR KEGG; pai:PAE1702; -.
DR PATRIC; fig|178306.9.peg.1258; -.
DR eggNOG; arCOG04064; Archaea.
DR HOGENOM; CLU_666698_0_0_2; -.
DR InParanoid; Q8ZWN5; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0031293; P:membrane protein intracellular domain proteolysis; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001193; MBTPS2.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR13325:SF3; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE; 1.
DR PANTHER; PTHR13325; PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
DR PRINTS; PR01000; SREBPS2PTASE.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002439};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 136..480
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
SQ SEQUENCE 502 AA; 54321 MW; 53910CD6D0C46EB1 CRC64;
MDSVIVFIAS WFVIIAVVYI INKKAVKYYV AIYWKSENLV KYVVKFTKRL SFVPKKAYLI
VVLVLFALPV FLAMPFVRPD GQILIIQGFL FMLISGAFNA VQSLLGGASV AEAASRSAGV
TPIIPGVTLP WDQLPYMAVA VVLAVVLHEL MHGYAALRYN IPVKSVGVFS IFYVLSGAFV
EPDEDSFKKA SVEAKAAVLA SGVAVNVVLA LAAMLIGVLG AWAGLQGAVF GVSAYNIPAG
DRVIEIRGCG MHEKVYTPDD FITKLNILAG LGPLLGVNKT ADCKPGDKVT LVASSWLHKY
EVTLDYANFT TSPRINWLYT DGSLYLGGVR PGDVVKKIEG CGRVWEVRSG GELLKAVIET
RGVCKPGDVV KVYVQRNATL LVLNVTLVER GGKIFYGLGP GSLPMLGYDE GPIKRNELYN
TDFTKLIFWL IVVNYGLAVL NALPIYPLDG GQLLAAVVQR KLGEKKGGAV VSAVTWILAA
ILIFNLALGV LGEQYRILQS IR
//
