ID Q8ZWW0_PYRAE Unreviewed; 822 AA.
AC Q8ZWW0;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=Aminopeptidase {ECO:0000313|EMBL:AAL63589.1};
GN OrderedLocusNames=PAE1597 {ECO:0000313|EMBL:AAL63589.1};
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306 {ECO:0000313|EMBL:AAL63589.1, ECO:0000313|Proteomes:UP000002439};
RN [1] {ECO:0000313|EMBL:AAL63589.1, ECO:0000313|Proteomes:UP000002439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 /
RC IM2 {ECO:0000313|Proteomes:UP000002439};
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136}.
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DR EMBL; AE009441; AAL63589.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZWW0; -.
DR STRING; 178306.PAE1597; -.
DR EnsemblBacteria; AAL63589; AAL63589; PAE1597.
DR KEGG; pai:PAE1597; -.
DR PATRIC; fig|178306.9.peg.1178; -.
DR eggNOG; arCOG02969; Archaea.
DR HOGENOM; CLU_014298_0_1_2; -.
DR InParanoid; Q8ZWW0; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0043171; P:peptide catabolic process; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09603; M1_APN_like; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR001930; Peptidase_M1.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533:SF303; AMINOPEPTIDASE N; 1.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR Pfam; PF13646; HEAT_2; 2.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR PRINTS; PR00756; ALADIPTASE.
DR SMART; SM00567; EZ_HEAT; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:AAL63589.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002439};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 30..188
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 223..443
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT COILED 789..820
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 822 AA; 95709 MW; 54B2A2781BBB4913 CRC64;
MAMRYLVGRD FAFPEYLPRF PPEYHFEVSH MQLDITIDVE GGWVEGVVRY RAKAKKDRAA
VVLDAMEMEI LEASHEYFYD GSKVEIKPEW KRGDPVEIYV KYRTRPRAGM YFIKTGKGYY
VWTQGESEYN RYWVPLPDSP NIKFPWTVAI TVPKPYIAGS NGVLIEVKDR GERQTFVWDL
KHPMSPYLLA IAVGDFEIHR EKCGDVVLEF YIPRYVDDRW RFSFYNTCRI MQFFSEYLGV
PFPYERYAQV VVPEFIYGGM ENTTFTILTD WTIHDKHAHC PYTGFPCPER EDFSSDPLVA
HEMAHMWFGD LVTAKDWAHI AINESFATFI EALWTEAHKG REEYLYEIYT NFKTYLGEFS
RRYSRPIVTN LYKIPDEVFD RHAYEKGSVV LHTLRSILGD DVFRKALKLF LERHRYKAVD
FEDLRKAFEE TAGRDLEWFW RQFWYSAGHP VLKVSWSYSE GAIKLQIKQA QGEDSYPVYT
LPLEIKIVYE DGRREVKEVF LNMKEVTLYI EGGKPKYICV DPSFKIIKAL DLQYPLESAV
AMIDDDDMYC KIQAIEVLKK NGSPRAVNAL AKAVGDKFWG VAAEAARALG EIGTEEAMAK
LTEAFKKSLH PRVRRVIVEA LGNTKRKEAG EFLDKILHDA GESYYVRAEA ARALGKVKWE
FAEFSLKKAL EYPSHLDVIK RGALEGLAEL GTEEALKIVL RHAEPGMPTP VRVSAVQSLA
KFGPRKEVID ALKRYMRDDN FRMRYAAVTA ALELLEPRLL QDLQERAEQD IDGRIRRVAR
EIVEKIKKSM ERGAEYQKLR EEVEKLREEY RKLLDRIARL EK
//
