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Database: UniProt
Entry: Q90029
LinkDB: Q90029
Original site: Q90029 
ID   KITH_RACVI              Reviewed;         177 AA.
AC   Q90029;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   RecName: Full=Thymidine kinase;
DE            EC=2.7.1.21;
GN   Name=TK;
OS   Raccoon poxvirus (RCN).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Orthopoxvirus.
OX   NCBI_TaxID=10256;
OH   NCBI_TaxID=9654; Procyon lotor (Raccoon).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Herman;
RX   PubMed=7483292; DOI=10.1007/BF01724299;
RA   Lutze-Wallace C., Sidhu M., Kappeler A.;
RT   "Nucleotide sequence of the thymidine kinase gene of raccoon
RT   poxvirus.";
RL   Virus Genes 10:81-84(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21;
CC   -!- SIMILARITY: Belongs to the thymidine kinase family. {ECO:0000305}.
DR   EMBL; U08228; AAA93128.1; -; Genomic_DNA.
DR   RefSeq; YP_009143402.1; NC_027213.1.
DR   ProteinModelPortal; Q90029; -.
DR   SMR; Q90029; -.
DR   GeneID; 24528124; -.
DR   KEGG; vg:24528124; -.
DR   OrthoDB; 16391at10239; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA synthesis; Kinase; Metal-binding; Nucleotide-binding;
KW   Transferase; Zinc.
FT   CHAIN         1    177       Thymidine kinase.
FT                                /FTId=PRO_0000174934.
FT   NP_BIND      11     18       ATP. {ECO:0000250}.
FT   REGION      157    161       Substrate binding. {ECO:0000250}.
FT   ACT_SITE     83     83       Proton acceptor. {ECO:0000255}.
FT   METAL       138    138       Zinc. {ECO:0000250}.
FT   METAL       141    141       Zinc. {ECO:0000250}.
FT   METAL       170    170       Zinc. {ECO:0000250}.
FT   METAL       173    173       Zinc. {ECO:0000250}.
FT   BINDING     113    113       Substrate; via amide nitrogen.
FT                                {ECO:0000250}.
SQ   SEQUENCE   177 AA;  20091 MW;  6524D5FB3F66D4E3 CRC64;
     MNGGHIQLII GPMFSGKSTE LIRRVRRYQI AQYKCITIKY TNDTRYGTGL WTHDKHNFSA
     METTKLLNII DAVTDFSVIG IDEGQFFPDI VEFCEYMANN GKIVIVAALD GTFQRKPFTT
     ISNLIPLSEM VVKLTAVCMK CFKEASFSKR LGTETEIEII GGEDMYQSVC RKCYINE
//
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