GenomeNet

Database: UniProt
Entry: Q90827
LinkDB: Q90827
Original site: Q90827 
ID   NEL_CHICK               Reviewed;         816 AA.
AC   Q90827;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JAN-2019, entry version 116.
DE   RecName: Full=Protein NEL;
DE   AltName: Full=93 kDa protein;
DE   Flags: Precursor;
GN   Name=NEL;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7655083; DOI=10.1002/aja.1002030209;
RA   Matsuhashi S., Noji S., Koyama E., Myokai F., Ohuchi H., Taniguchi S.,
RA   Hori K.;
RT   "New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is
RT   strongly expressed in neural tissues of early stage chick embryos.";
RL   Dev. Dyn. 203:212-222(1995).
CC   -!- TISSUE SPECIFICITY: Strongly expressed in early embryonic neural
CC       tissues (brain, spinal cord, dorsal root ganglia); less in other
CC       tissues such as cells around cartilage, myocardium, lung
CC       mesenchymal cells, and liver. After hatching expression is
CC       restricted to neural tissues including retina.
DR   EMBL; D86747; BAA13167.1; -; mRNA.
DR   RefSeq; NP_001025911.1; NM_001030740.1.
DR   UniGene; Gga.595; -.
DR   ProteinModelPortal; Q90827; -.
DR   SMR; Q90827; -.
DR   STRING; 9031.ENSGALP00000037995; -.
DR   PaxDb; Q90827; -.
DR   GeneID; 417799; -.
DR   KEGG; gga:417799; -.
DR   CTD; 4753; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410XP6K; LUCA.
DR   HOGENOM; HOG000217920; -.
DR   HOVERGEN; HBG004805; -.
DR   InParanoid; Q90827; -.
DR   OrthoDB; 767046at2759; -.
DR   PhylomeDB; Q90827; -.
DR   PRO; PR:Q90827; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005623; C:cell; IDA:AgBase.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF07645; EGF_CA; 4.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF00093; VWC; 2.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 5.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 4.
DR   PROSITE; PS50026; EGF_3; 6.
DR   PROSITE; PS01187; EGF_CA; 3.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Reference proteome; Repeat; Signal.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    816       Protein NEL.
FT                                /FTId=PRO_0000007663.
FT   DOMAIN       65    228       Laminin G-like.
FT   DOMAIN      272    331       VWFC 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      397    439       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      440    481       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      482    522       EGF-like 3; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      523    553       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      555    601       EGF-like 5; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      602    637       EGF-like 6; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      638    693       VWFC 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      698    756       VWFC 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   CARBOHYD     53     53       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    225    225       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    293    293       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    298    298       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    517    517       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    615    615       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    635    635       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    401    413       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    407    422       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    424    438       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    444    457       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    451    466       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    468    480       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    486    499       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    493    508       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    510    521       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    525    535       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    529    541       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    543    552       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    559    572       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    566    581       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    583    600       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    606    619       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    613    628       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    630    636       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   816 AA;  90969 MW;  BFCDBC983C02F831 CRC64;
     MESGCGLGTL CLLLCLGPVV GFGVDPSLQI DVLSELGLPG YAAGVRQVPG LHNGSKAFLF
     PDTSRSVKAS PETAEIFFQK LRNKYEFTIL VTLKQAHLNS GVIFSIHHLD HRYLELESSG
     HRNEIRLHYR TGSHRSHTEV FPYILADDKW HRLSLAISAS HLILHVDCNK IYERVVEKPF
     MDLPVGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFISQ CPDLNRTCPT CNDFHGLVQK
     IMELQDILAK TSAKLSQAEQ RMNKLDQCYC ERTCTMKGMT YREFESWTDG CKNCTCMNGT
     VQCEALICSL SDCPPNSALS YVDGKCCKEC QSVCIFEGRT YFEGQRETVY SSSGDCVLFE
     CKDHKMQRIP KDSCATLNCP ESQQIPLSHS CCKICKGHDF CTEGHNCMEH SVCRNLDDRA
     VCSCRDGFRA LREDNAYCED VDECAEGQHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC
     TEHDECVTNQ HNCDENALCF NTVGGHNCVC KLGYTGNGTV CKAFCKDGCR NGGACIASNV
     CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC
     EDIDECATGR HSCANDTVCF NLDGGYDCRC PHGKNCTGDC IHEDKIKHNG QIWVLENDRC
     SVCSCQSGYV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQSGELSYN SGDSWIQNCQ
     QCRCLQGEVD CWPLPCPEVD CEFSVLPENE CCPRCVTDPC QADTIRNDIT KTCLDETNVV
     RFTGSSWIKH GTECTLCQCK NGHVCCSVDP QCLQEL
//
DBGET integrated database retrieval system