ID Q90847_CHICK Unreviewed; 354 AA.
AC Q90847; A0A1D5PDQ8; A0A1L1RV96;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=Guanine nucleotide-binding protein G(i) subunit alpha-3 {ECO:0000256|ARBA:ARBA00039890};
DE AltName: Full=G(i) alpha-3 {ECO:0000256|ARBA:ARBA00041800};
GN Name=Galphai3 {ECO:0000313|EMBL:AAA48776.1};
GN Synonyms=GNAI3 {ECO:0000313|Ensembl:ENSGALP00010041108.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAA48776.1};
RN [1] {ECO:0000313|EMBL:AAA48776.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8297335;
RA Kilbourne E.J., Galper J.B.;
RT "Isolation and expression of a novel chick G-protein cDNA coding for a G
RT alpha i3 protein with a G alpha 0 N-terminus.";
RL Biochem. J. 297:303-308(1994).
RN [2] {ECO:0000313|Ensembl:ENSGALP00010041108.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010041108.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC {ECO:0000256|ARBA:ARBA00006628}.
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DR EMBL; L24550; AAA48776.1; -; Genomic_DNA.
DR PIR; I50230; S40508.
DR STRING; 9031.ENSGALP00000062750; -.
DR Ensembl; ENSGALT00010067204.1; ENSGALP00010041108.1; ENSGALG00010027722.1.
DR VEuPathDB; HostDB:geneid_374097; -.
DR GeneTree; ENSGT00940000153567; -.
DR OMA; RICAPNY; -.
DR OrthoDB; 2897309at2759; -.
DR Reactome; R-GGA-170670; Adenylate cyclase inhibitory pathway.
DR Reactome; R-GGA-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR Reactome; R-GGA-9009391; Extra-nuclear estrogen signaling.
DR Proteomes; UP000000539; Chromosome 26.
DR Bgee; ENSGALG00000041700; Expressed in granulocyte and 13 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0019003; F:GDP binding; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:Ensembl.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0046039; P:GTP metabolic process; IEA:Ensembl.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF230; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-3; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00441; GPROTEINAI.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q90847};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 354 AA; 40517 MW; D08B65E7BA19A08D CRC64;
MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG
YSEEECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEVAR ADDARQLFVL AGSAEEGVMT
AELAGVIKRL WRDAGVQACF SRSREYQLND SASYYLNDLD RISQPTYIPT QQDVLRTRVK
TTGIVETHFT FKDLYFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM
NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKIKK SPLTICYPEY TGSNTYEEAA
AYIQCQFEDL NRRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKE CGLY
//
