ID Q90XR2_DANRE Unreviewed; 218 AA.
AC Q90XR2; F6NVG7; Q6P0W4;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE RecName: Full=Claudin-3 {ECO:0000256|ARBA:ARBA00022063};
GN Name=cldn3d {ECO:0000313|ZFIN:ZDB-GENE-010328-3};
GN Synonyms=cldnc {ECO:0000313|EMBL:AAL01839.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH65424.1};
RN [1] {ECO:0000313|EMBL:AAL01839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11517306; DOI=10.1073/pnas.171325898;
RA Kollmar R., Nakamura S.K., Kappler J.A., Hudspeth A.J.;
RT "Expression and phylogeny of claudins in vertebrate primordia.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:10196-10201(2001).
RN [2] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15197168; DOI=10.1101/gr.2400004;
RA Loh Y.H., Christoffels A., Brenner S., Hunziker W., Venkatesh B.;
RT "Extensive expansion of the claudin gene family in the teleost fish, Fugu
RT rubripes.";
RL Genome Res. 14:1248-1257(2004).
RN [3] {ECO:0000313|EMBL:AAH65424.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH65424.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19563808;
RA Stuckenholz C., Lu L., Thakur P., Kaminski N., Bahary N.;
RT "FACS-assisted microarray profiling implicates novel genes and pathways in
RT zebrafish gastrointestinal tract development.";
RL Gastroenterology 137:1321-1332(2009).
RN [5] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19874812;
RA Feng L., Hernandez R.E., Waxman J.S., Yelon D., Moens C.B.;
RT "Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition
RT mechanism.";
RL Dev. Biol. 338:1-14(2010).
RN [6] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20553723;
RA Clelland E.S., Kelly S.P.;
RT "Tight junction proteins in zebrafish ovarian follicles: stage specific
RT mRNA abundance and response to 17beta-estradiol, human chorionic
RT gonadotropin, and maturation inducing hormone.";
RL Gen. Comp. Endocrinol. 168:388-400(2010).
RN [7] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21600298;
RA Kumai Y., Bahubeshi A., Steele S., Perry S.F.;
RT "Strategies for maintaining Na(+) balance in zebrafish (Danio rerio) during
RT prolonged exposure to acidic water.";
RL Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 160:52-62(2011).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000002797}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000002797};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [9] {ECO:0000313|Ensembl:ENSDARP00000002797, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000002797};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [10] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25074470;
RA Xu F., Ye Y.T., Cai C.F., Wu P., Song L., Liu M., Yao L.J., Dong J.J.,
RA Huang Y.W., Gong Z., Qin J., Song L.;
RT "Observation of the middle intestinal tight junction structure, cloning and
RT studying tissue distribution of the four Claudin genes of the grass carp
RT (Ctenopharyngodon idellus).";
RL Fish Physiol. Biochem. 40:1783-1792(2014).
RN [11] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [12] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26933814;
RA Khatib A.M., Lahlil R., Hagedorn M., Delomenie C., Christophe O., Denis C.,
RA Siegfried G.;
RT "Biological outcome and mapping of total factor cascades in response to HIF
RT induction during regenerative angiogenesis.";
RL Oncotarget 7:12102-12120(2016).
RN [13] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26726070;
RA Shu Y., Lou Q., Dai Z., Dai X., He J., Hu W., Yin Z.;
RT "The basal function of teleost prolactin as a key regulator on ion uptake
RT identified with zebrafish knockout models.";
RL Sci. Rep. 6:18597-18597(2016).
RN [14] {ECO:0000313|RefSeq:NP_571839.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30590163;
RA Guo X., Li J., Ran C., Wang A., Xie M., Xie Y., Ding Q., Zhang Z., Yang Y.,
RA Duan M., Zhou Z.;
RT "Dietary nucleotides can directly stimulate the immunity of zebrafish
RT independent of the intestinal microbiota.";
RL Fish Shellfish Immunol. 86:1064-1071(2019).
RN [15] {ECO:0000313|RefSeq:NP_571839.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000256|ARBA:ARBA00002246}.
CC -!- SUBUNIT: Can form homo- and heteropolymers with other CLDN.
CC Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly
CC interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
CC {ECO:0000256|ARBA:ARBA00025914}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295}.
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DR EMBL; CR847847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC065424; AAH65424.1; -; mRNA.
DR EMBL; AF359432; AAL01839.1; -; mRNA.
DR RefSeq; NP_571839.1; NM_131764.1.
DR STRING; 7955.ENSDARP00000002797; -.
DR PaxDb; 7955-ENSDARP00000002797; -.
DR Ensembl; ENSDART00000002341; ENSDARP00000002797; ENSDARG00000015955.
DR Ensembl; ENSDART00000002341.6; ENSDARP00000002797.4; ENSDARG00000015955.6.
DR GeneID; 81582; -.
DR KEGG; dre:81582; -.
DR AGR; ZFIN:ZDB-GENE-010328-3; -.
DR CTD; 81582; -.
DR ZFIN; ZDB-GENE-010328-3; cldn3d.
DR eggNOG; ENOG502QRZ8; Eukaryota.
DR HOGENOM; CLU_076370_1_2_1; -.
DR OMA; TNCIEED; -.
DR OrthoDB; 4040914at2759; -.
DR TreeFam; TF331936; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000015955; Expressed in swim bladder and 29 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR003549; Claudin3.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF112; CLAUDIN-3; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
DR PRINTS; PR01378; CLAUDIN3.
PE 2: Evidence at transcript level;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 218 AA; 23426 MW; 82CA23D13306110F CRC64;
MASFGLELVG VTLSVLGWIL NIVCCALPMW RVTAFIGTNI VTAQVYWEGI WMSCVVQSTG
QMQCKVYDSM LALPADLQAA RALVVVAIIV GVLALFVAIV GAKCTNCIEE EAAKARVMIS
SGAAFITASV LQLIPVCWSA HTVILEFYSP LVPEAQKMEI GASLYLGWAA SAMLLVGGSI
LCCSCPPKDE TRYPPQSRIA YSAHHSVAPS TYNKRDYV
//
