GenomeNet

Database: UniProt
Entry: Q90Y54
LinkDB: Q90Y54
Original site: Q90Y54 
ID   JAG1B_DANRE             Reviewed;        1213 AA.
AC   Q90Y54;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   10-OCT-2018, entry version 129.
DE   RecName: Full=Protein jagged-1b;
DE            Short=Jagged1b;
DE   AltName: Full=Jagged3;
DE   Flags: Precursor;
GN   Name=jag1b; Synonyms=jag3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Oda T., Chandrasekharappa S.C.;
RT   "Isolation, characterization and expression analysis of zebrafish
RT   Jagged genes.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ligand for Notch receptors and involved in the mediation
CC       of Notch signaling (By similarity). Seems to be involved in cell-
CC       fate decisions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
DR   EMBL; AF229451; AAL08216.1; -; mRNA.
DR   UniGene; Dr.12589; -.
DR   ProteinModelPortal; Q90Y54; -.
DR   SMR; Q90Y54; -.
DR   STRING; 7955.ENSDARP00000008197; -.
DR   PaxDb; Q90Y54; -.
DR   PRIDE; Q90Y54; -.
DR   ZFIN; ZDB-GENE-011128-4; jag1b.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410XP6K; LUCA.
DR   HOGENOM; HOG000113124; -.
DR   HOVERGEN; HBG031645; -.
DR   InParanoid; Q90Y54; -.
DR   PhylomeDB; Q90Y54; -.
DR   PRO; PR:Q90Y54; -.
DR   Proteomes; UP000000437; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; NAS:ZFIN.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR   GO; GO:0060117; P:auditory receptor cell development; IMP:ZFIN.
DR   GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IMP:ZFIN.
DR   GO; GO:1904888; P:cranial skeletal system development; IMP:ZFIN.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
DR   GO; GO:0031017; P:exocrine pancreas development; IGI:ZFIN.
DR   GO; GO:0060325; P:face morphogenesis; IMP:ZFIN.
DR   GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR   GO; GO:0042472; P:inner ear morphogenesis; IMP:ZFIN.
DR   GO; GO:0035622; P:intrahepatic bile duct development; IGI:ZFIN.
DR   GO; GO:0001889; P:liver development; IGI:ZFIN.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR   GO; GO:0031016; P:pancreas development; IGI:ZFIN.
DR   GO; GO:0060872; P:semicircular canal development; IMP:ZFIN.
DR   GO; GO:0048752; P:semicircular canal morphogenesis; IMP:ZFIN.
DR   GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
DR   InterPro; IPR001774; DSL.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR026219; Jagged/Serrate.
DR   InterPro; IPR011651; Notch_ligand_N.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF01414; DSL; 1.
DR   Pfam; PF00008; EGF; 10.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF12661; hEGF; 2.
DR   Pfam; PF07657; MNNL; 1.
DR   PRINTS; PR02059; JAGGEDFAMILY.
DR   SMART; SM00051; DSL; 1.
DR   SMART; SM00181; EGF; 16.
DR   SMART; SM00179; EGF_CA; 14.
DR   SMART; SM00214; VWC; 1.
DR   SMART; SM00215; VWC_out; 1.
DR   SUPFAM; SSF57184; SSF57184; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 10.
DR   PROSITE; PS51051; DSL; 1.
DR   PROSITE; PS00022; EGF_1; 16.
DR   PROSITE; PS01186; EGF_2; 12.
DR   PROSITE; PS50026; EGF_3; 15.
DR   PROSITE; PS01187; EGF_CA; 8.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Developmental protein; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27   1213       Protein jagged-1b.
FT                                /FTId=PRO_0000007631.
FT   TOPO_DOM     27   1064       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1065   1087       Helical. {ECO:0000255}.
FT   TOPO_DOM   1088   1213       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      182    226       DSL. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00377}.
FT   DOMAIN      227    260       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      261    291       EGF-like 2; atypical.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      293    331       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      333    369       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      371    407       EGF-like 5; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      409    445       EGF-like 6; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      447    482       EGF-like 7; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      484    520       EGF-like 8; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      522    558       EGF-like 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      592    624       EGF-like 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      626    662       EGF-like 11; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      664    700       EGF-like 12; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      702    738       EGF-like 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      746    777       EGF-like 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      779    815       EGF-like 15; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      817    853       EGF-like 16; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      860    914       VWFC.
FT   DOMAIN      918    956       EGF-like 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   COMPBIAS    938    941       Poly-Pro.
FT   CARBOHYD    139    139       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    214    214       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    556    556       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    742    742       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    957    957       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    988    988       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1042   1042       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    184    193       {ECO:0000250}.
FT   DISULFID    197    209       {ECO:0000250}.
FT   DISULFID    217    226       {ECO:0000250}.
FT   DISULFID    231    242       {ECO:0000250}.
FT   DISULFID    235    248       {ECO:0000250}.
FT   DISULFID    250    259       {ECO:0000250}.
FT   DISULFID    262    273       {ECO:0000250}.
FT   DISULFID    268    279       {ECO:0000250}.
FT   DISULFID    281    290       {ECO:0000250}.
FT   DISULFID    297    309       {ECO:0000250}.
FT   DISULFID    303    319       {ECO:0000250}.
FT   DISULFID    321    330       {ECO:0000250}.
FT   DISULFID    337    348       {ECO:0000250}.
FT   DISULFID    342    357       {ECO:0000250}.
FT   DISULFID    359    368       {ECO:0000250}.
FT   DISULFID    375    386       {ECO:0000250}.
FT   DISULFID    380    395       {ECO:0000250}.
FT   DISULFID    397    406       {ECO:0000250}.
FT   DISULFID    413    424       {ECO:0000250}.
FT   DISULFID    418    433       {ECO:0000250}.
FT   DISULFID    435    444       {ECO:0000250}.
FT   DISULFID    451    461       {ECO:0000250}.
FT   DISULFID    455    470       {ECO:0000250}.
FT   DISULFID    472    481       {ECO:0000250}.
FT   DISULFID    488    499       {ECO:0000250}.
FT   DISULFID    493    508       {ECO:0000250}.
FT   DISULFID    510    519       {ECO:0000250}.
FT   DISULFID    526    537       {ECO:0000250}.
FT   DISULFID    531    546       {ECO:0000250}.
FT   DISULFID    548    557       {ECO:0000250}.
FT   DISULFID    596    612       {ECO:0000250}.
FT   DISULFID    614    623       {ECO:0000250}.
FT   DISULFID    630    641       {ECO:0000250}.
FT   DISULFID    635    650       {ECO:0000250}.
FT   DISULFID    652    661       {ECO:0000250}.
FT   DISULFID    668    679       {ECO:0000250}.
FT   DISULFID    673    688       {ECO:0000250}.
FT   DISULFID    690    699       {ECO:0000250}.
FT   DISULFID    706    717       {ECO:0000250}.
FT   DISULFID    711    726       {ECO:0000250}.
FT   DISULFID    728    737       {ECO:0000250}.
FT   DISULFID    745    756       {ECO:0000250}.
FT   DISULFID    750    765       {ECO:0000250}.
FT   DISULFID    767    776       {ECO:0000250}.
FT   DISULFID    783    794       {ECO:0000250}.
FT   DISULFID    788    803       {ECO:0000250}.
FT   DISULFID    805    814       {ECO:0000250}.
FT   DISULFID    821    832       {ECO:0000250}.
FT   DISULFID    826    841       {ECO:0000250}.
FT   DISULFID    843    852       {ECO:0000250}.
SQ   SEQUENCE   1213 AA;  133366 MW;  5C5F16A7E20D9534 CRC64;
     MILRRSSVFS AFYLHAFLLC LRTTVSDASG HFELEILSMQ NANGELQNGA CCDGARNPAD
     RKCTRDECDT YFKVCLKEYQ SRVSSAGACS FGTGSTPVLG GNKFSTKGTR SEKSRIVLPF
     SFAWPRSYTL IVEALDFNNE TASESGKLIE KAYHSGMINP NRQWQRLTHN GPVAQFEYQI
     RVTCLEHYYG FGCNKFCRPR DEFFGHYTCD QNGNKTCLEG WTGPDCNTAI CRQGCSTEHG
     SCKQPGGCKC LYGWQGPYCD KCIPHPGCVH GTCVEPWQCL CDTNWGGQLC DKDLNYCGTH
     QPCLNGGTCS NTGPDKYQCS CEDGYSGVNC ERAEHACLSN PCANGGTCKE TSQGYECHCA
     IGWSGTSCEI NVDDCTPNQC KHGGTCQDLV NGFKCACPPH WTGKTCQIDA NECEDKPCVN
     AKSCHNLIGA YFCECLPGWS GQNCDININD CKGQCLNGGT CKDLVNGYRC LCPPGYTGEQ
     CEKDVDECAS SPCLNGGRCQ DEVNGFQCLC PAGFSGQLCQ LDIDYCKPNP CQNGAQCFNL
     ASDYFCKCPD DYEGKNCSHL KDHCRTTSCQ VIDSCTVAVA SNSTPEGVRY ISSNVCGPHG
     RCRSQAGGQF TCECQEGFRG TYCHENINDC ESNPCRNGGT CIDKVNVYQC ICADGWEGVH
     CEINIDDCSL NPCLNKGACQ DLVNDFYCEC RNGWKGKTCH SRDSQCDEAT CNNGGTCHDE
     GDTFKCRCSP GWEGATCNIA KNSSCLPNPC ENGGTCVVNG DSFNCVCKEG WEGSTCTENT
     NDCNPHPCYN SGTCVDGENW YRCECAPGFA GPDCRININE CQSSPCAFGS TCVDEINGYR
     CLCPPGRIGP DCQEVVGRPC IANGQVTADG AKWEEDCNIC QCQNGRIHCT MMWCGPKSCR
     IGKARGGCPA SQSCVPIKEE QCFVKPCPSL GECWPSAPPP PSKCHASFSY QDDSCANITF
     TFNKENMPQG LSVEHVCNEL RHWYLLKNLS TEYAVSISCE PSSSASNEIH ISISTEEPRT
     DRSPIKDITV QIIDLVSKHN GNSTIIKAIT GVRVHQIPSP KTDYLVPLLS SIFIVLWIFA
     LASAFLWCIH RRRKQNTHSN TATSATEDNT TNNVREQLNQ IKNPIEKHAA HGVPIKDYEG
     KNSIIAKIRT HNSEVEEEDM DKHLQKARFT KQPAYTLVER EERAPNKNPN WTNKQDNRDL
     ETAQSLNRME YIV
//
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