ID Q90Z40_DANRE Unreviewed; 75 AA.
AC Q90Z40; B2GP68;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 147.
DE RecName: Full=Guanine nucleotide-binding protein subunit gamma {ECO:0000256|RuleBase:RU004973};
GN Name=gng3 {ECO:0000313|EMBL:AAI64230.1,
GN ECO:0000313|Ensembl:ENSDARP00000015972,
GN ECO:0000313|RefSeq:NP_571916.1, ECO:0000313|ZFIN:ZDB-GENE-010705-1};
GN Synonyms=wu:fj56b02 {ECO:0000313|RefSeq:NP_571916.1}, zgc:92852
GN {ECO:0000313|RefSeq:NP_571916.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI64230.1};
RN [1] {ECO:0000313|EMBL:AAK61350.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11378305; DOI=10.1016/S0736-5748(01)00002-8;
RA Kelly G.M., Vanderbeld B., Krawetz R., Mangos S.;
RT "Differential distribution of the G protein gamma3 subunit in the
RT developing zebrafish nervous system.";
RL Int. J. Dev. Neurosci. 19:455-467(2001).
RN [2] {ECO:0000313|EMBL:AAI64230.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAH76314.1}, and PCR rescue
RC {ECO:0000313|EMBL:AAI64230.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_571916.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19500364;
RA Sato Y., Hashiguchi Y., Nishida M.;
RT "Temporal pattern of loss/persistence of duplicate genes involved in signal
RT transduction and metabolic pathways after teleost-specific genome
RT duplication.";
RL BMC Evol. Biol. 9:127-127(2009).
RN [4] {ECO:0000313|RefSeq:NP_571916.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19786091;
RA Mulligan T., Blaser H., Raz E., Farber S.A.;
RT "Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in
RT the zebrafish.";
RL Cell. Signal. 22:221-233(2010).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000015972}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000015972};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [6] {ECO:0000313|Ensembl:ENSDARP00000015972, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000015972};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_571916.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_571916.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [9] {ECO:0000313|RefSeq:NP_571916.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26982811;
RA Mullally M., Albrecht C., Horton M., Laboissonniere L.A., Goetz J.J.,
RA Chowdhury R., Manning A., Wester A.K., Bose Q., Trimarchi J.M.;
RT "Expression Profiling of Developing Zebrafish Retinal Cells.";
RL Zebrafish 13:272-280(2016).
RN [10] {ECO:0000313|RefSeq:NP_571916.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [11] {ECO:0000313|RefSeq:NP_571916.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction. {ECO:0000256|RuleBase:RU004973}.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma.
CC {ECO:0000256|RuleBase:RU004973}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU004973};
CC Lipid-anchor {ECO:0000256|RuleBase:RU004973}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU004973}.
CC -!- SIMILARITY: Belongs to the G protein gamma family.
CC {ECO:0000256|ARBA:ARBA00007431, ECO:0000256|RuleBase:RU004973}.
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DR EMBL; BX465841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC076314; AAH76314.1; -; mRNA.
DR EMBL; BC164230; AAI64230.1; -; mRNA.
DR EMBL; AF364083; AAK61350.1; -; mRNA.
DR RefSeq; NP_571916.1; NM_131841.2.
DR STRING; 7955.ENSDARP00000015972; -.
DR PaxDb; 7955-ENSDARP00000015972; -.
DR Ensembl; ENSDART00000004109.7; ENSDARP00000015972.5; ENSDARG00000009553.7.
DR GeneID; 114462; -.
DR KEGG; dre:114462; -.
DR AGR; ZFIN:ZDB-GENE-010705-1; -.
DR CTD; 2785; -.
DR ZFIN; ZDB-GENE-010705-1; gng3.
DR eggNOG; KOG4119; Eukaryota.
DR HOGENOM; CLU_168377_0_1_1; -.
DR OMA; NAHACED; -.
DR OrthoDB; 2872810at2759; -.
DR TreeFam; TF319909; -.
DR Reactome; R-DRE-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-DRE-202040; G-protein activation.
DR Reactome; R-DRE-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-DRE-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-DRE-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-DRE-392851; Prostacyclin signalling through prostacyclin receptor.
DR Reactome; R-DRE-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-DRE-4086398; Ca2+ pathway.
DR Reactome; R-DRE-416476; G alpha (q) signalling events.
DR Reactome; R-DRE-416482; G alpha (12/13) signalling events.
DR Reactome; R-DRE-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-DRE-418555; G alpha (s) signalling events.
DR Reactome; R-DRE-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-DRE-418594; G alpha (i) signalling events.
DR Reactome; R-DRE-418597; G alpha (z) signalling events.
DR Reactome; R-DRE-420092; Glucagon-type ligand receptors.
DR Reactome; R-DRE-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-DRE-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-DRE-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-DRE-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-DRE-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-DRE-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-DRE-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-DRE-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-DRE-9634597; GPER1 signaling.
DR Reactome; R-DRE-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000009553; Expressed in brain and 21 other cell types or tissues.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809:SF11; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-3; 1.
DR PANTHER; PTHR13809; GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU004973};
KW Lipoprotein {ECO:0000256|RuleBase:RU004973};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004973};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU004973}.
FT DOMAIN 9..75
FT /note="G protein gamma"
FT /evidence="ECO:0000259|PROSITE:PS50058"
SQ SEQUENCE 75 AA; 8263 MW; 30973B331BE68DAB CRC64;
MKGDTPVNST MSVGQARKLV EQLKIEASFC RIKVSKAAAD LMAYCDAHAC EDPLITPVPT
SENPFREKKF FCALL
//
