ID MTPN_CHICK Reviewed; 118 AA.
AC Q91955; Q5ZHL6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE RecName: Full=Myotrophin;
DE AltName: Full=Granule cell differentiation protein;
DE AltName: Full=Protein V-1;
GN Name=MTPN; ORFNames=RCJMB04_23o21, RCJMB04_35l16;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lens fibers;
RX PubMed=8840185;
RA Sawada K., Agata K., Eguchi G.;
RT "Characterization of terminally differentiated cell state by categorizing
RT cDNA clones derived from chicken lens fibers.";
RL Int. J. Dev. Biol. 40:531-535(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Regulates NF-kappa-B transcription factor activity. Promotes
CC growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes
CC cardiac muscle hypertrophy. Plays a role in the regulation of the
CC growth of actin filaments. Inhibits the activity of the F-actin-capping
CC protein complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Cytoplasm, perinuclear region {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the myotrophin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D26326; BAA05379.1; -; mRNA.
DR EMBL; AJ720711; CAG32370.1; -; mRNA.
DR EMBL; AJ721118; CAG32777.1; -; mRNA.
DR RefSeq; NP_990217.1; NM_204886.2.
DR AlphaFoldDB; Q91955; -.
DR SMR; Q91955; -.
DR STRING; 9031.ENSGALP00000056408; -.
DR PaxDb; 9031-ENSGALP00000042167; -.
DR Ensembl; ENSGALT00000059596; ENSGALP00000056408; ENSGALG00000041619.
DR Ensembl; ENSGALT00015049134; ENSGALP00015028598; ENSGALG00015020113.
DR GeneID; 395702; -.
DR KEGG; gga:395702; -.
DR VEuPathDB; HostDB:geneid_395702; -.
DR eggNOG; KOG4214; Eukaryota.
DR InParanoid; Q91955; -.
DR PhylomeDB; Q91955; -.
DR PRO; PR:Q91955; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000041619; Expressed in spleen and 13 other cell types or tissues.
DR GO; GO:0030424; C:axon; ISS:AgBase.
DR GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.
DR GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0010557; P:positive regulation of macromolecule biosynthetic process; ISS:UniProtKB.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0051247; P:positive regulation of protein metabolic process; ISS:UniProtKB.
DR GO; GO:2000812; P:regulation of barbed-end actin filament capping; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24171; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR PANTHER; PTHR24171:SF8; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 3: Inferred from homology;
KW ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..118
FT /note="Myotrophin"
FT /id="PRO_0000067034"
FT REPEAT 1..30
FT /note="ANK 1"
FT REPEAT 34..65
FT /note="ANK 2"
FT REPEAT 67..98
FT /note="ANK 3"
SQ SEQUENCE 118 AA; 12886 MW; 6097EB55C6CBD2CF CRC64;
MSDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD
INAPDKHNIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKTLLQ
//
