ID Q91Y06_MOUSE Unreviewed; 796 AA.
AC Q91Y06;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 156.
DE SubName: Full=Protocadherin beta 13 {ECO:0000313|EMBL:AAK26063.1, ECO:0000313|Ensembl:ENSMUSP00000061087.2};
GN Name=Pcdhb13 {ECO:0000313|EMBL:AAI38124.1,
GN ECO:0000313|Ensembl:ENSMUSP00000061087.2,
GN ECO:0000313|MGI:MGI:2136748};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAK26063.1};
RN [1] {ECO:0000313|EMBL:AAK26063.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AAK26063.1};
RX PubMed=10380929; DOI=10.1016/S0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2] {ECO:0000313|EMBL:AAK26063.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AAK26063.1};
RX PubMed=10716726; DOI=10.1073/pnas.060027397;
RA Wu Q., Maniatis T.;
RT "Large exons encoding multiple ectodomains are a characteristic feature of
RT protocadherin genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000).
RN [3] {ECO:0000313|EMBL:AAK26063.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AAK26063.1};
RX PubMed=11230163; DOI=10.1101/gr.167301;
RA Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M.,
RA Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.;
RT "Comparative DNA sequence analysis of mouse and human protocadherin gene
RT clusters.";
RL Genome Res. 11:389-404(2001).
RN [4] {ECO:0000313|EMBL:AAI38124.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI38124.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000061087.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000061087.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000061087.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000061087.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC138123; AAI38124.1; -; mRNA.
DR EMBL; BC138124; AAI38125.1; -; mRNA.
DR EMBL; AY013774; AAK26063.1; -; mRNA.
DR RefSeq; NP_444368.1; NM_053138.2.
DR STRING; 10090.ENSMUSP00000061087; -.
DR PaxDb; 10090-ENSMUSP00000061087; -.
DR ProteomicsDB; 332717; -.
DR Antibodypedia; 27197; 53 antibodies from 10 providers.
DR DNASU; 93884; -.
DR Ensembl; ENSMUST00000056915.3; ENSMUSP00000061087.2; ENSMUSG00000047307.3.
DR GeneID; 93884; -.
DR KEGG; mmu:93884; -.
DR UCSC; uc008epy.1; mouse.
DR AGR; MGI:2136748; -.
DR CTD; 56123; -.
DR MGI; MGI:2136748; Pcdhb13.
DR VEuPathDB; HostDB:ENSMUSG00000047307; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000163433; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR OMA; GREMEEN; -.
DR OrthoDB; 5402790at2759; -.
DR TreeFam; TF332299; -.
DR BioGRID-ORCS; 93884; 1 hit in 77 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 18.
DR Bgee; ENSMUSG00000047307; Expressed in lumbar subsegment of spinal cord and 20 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF104; PROTOCADHERIN BETA-6; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..796
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015099541"
FT TRANSMEM 686..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..132
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 133..241
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 242..345
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 359..449
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 450..559
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 574..674
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 775..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 87589 MW; 336EB1D6B70561C7 CRC64;
MSHAKMWCKT RQVMVLITSM LLWEVGSGSI QYAMLEETES GTFVANLTKH LGLRVGELAA
RDARVVFKGN RQYLQLDPQT QDLMLNENLD REELCGSTEP CVLSFRVLLK NPLQFYQAEL
RVIDINDHAP EFPAREMLLK ISEIAPPGKI FPLKMAQDLD TGSHSIQSYT VSDNPHFHVL
TRNRSDGKKF PELVLDKALD REKQDQLRLK LTAVDGGSPP RSGTTEIQIL VLDINDNTPE
FAQELYEVQV PENSPIGSLL ITVSARDLDA GPFGEVSYGL SQDDDVNEPF EINTKTGEIR
LKSTLDFEAF QSYHVDVEAL DGGGLTGKCS LVVQVLDVND NAPEVILSSL NSPIPENLPG
IIVAVFSVSD ADSGNNQQVM CSIDDNLPFL LRPSMENFYT LETDGALDRE SRSEYNITIT
VTDMGTPRLT TQHNITVQVS DINDNAPAFT QTSYTLFVHE NNSPALHIGT ISATDSDSGS
NAHITYSLLL PQDKQLTLTS LVSINADNGQ LFALRALDYE ALQAFEFRVD ATDQGSPALS
SQVLVRVVVL DDNDNAPFVL YPMQNASAPC TELLPRAAEP GYLVTKVVAV DRDSGQNAWL
SFQLFKATEP GLFSVWAHNG EVRTTRLLSE RDVPKHRLLL LVKDNGEPPR SASVTLHVLL
VDGFSQPYLP LPEVAQDSTE DAEDALTLYL VIALASVSSL FLLSVVLFVG VRLCKKFRAA
SLGGYSVPEG HFPGHLVDVS GAGTLSQSYQ YEVCLRGDTG TGEFKLRKAI NPHFPSVPSE
RNTEESPTLR NSFLFI
//
