ID Q91Y12_MOUSE Unreviewed; 946 AA.
AC Q91Y12;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 158.
DE SubName: Full=Protocadherin alpha 8 {ECO:0000313|EMBL:AAK26055.1, ECO:0000313|Ensembl:ENSMUSP00000142159.2};
GN Name=Pcdha8 {ECO:0000313|EMBL:AAI39425.1,
GN ECO:0000313|Ensembl:ENSMUSP00000142159.2,
GN ECO:0000313|MGI:MGI:2681879};
GN Synonyms=Pcdha1 {ECO:0000313|MGI:MGI:2681879};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAK26055.1};
RN [1] {ECO:0000313|EMBL:AAK26055.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AAK26055.1};
RX PubMed=10380929; DOI=10.1016/S0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2] {ECO:0000313|EMBL:AAK26055.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AAK26055.1};
RX PubMed=10716726; DOI=10.1073/pnas.060027397;
RA Wu Q., Maniatis T.;
RT "Large exons encoding multiple ectodomains are a characteristic feature of
RT protocadherin genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000).
RN [3] {ECO:0000313|EMBL:AAK26055.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AAK26055.1};
RX PubMed=11230163; DOI=10.1101/gr.167301;
RA Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M.,
RA Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.;
RT "Comparative DNA sequence analysis of mouse and human protocadherin gene
RT clusters.";
RL Genome Res. 11:389-404(2001).
RN [4] {ECO:0000313|EMBL:AAI39425.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI39425.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000142159.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142159.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000142159.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000142159.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; BC139424; AAI39425.1; -; mRNA.
DR EMBL; BC139426; AAI39427.1; -; mRNA.
DR EMBL; AY013766; AAK26055.1; -; mRNA.
DR RefSeq; NP_957695.1; NM_201243.1.
DR ProteomicsDB; 337118; -.
DR DNASU; 353235; -.
DR Ensembl; ENSMUST00000194038.2; ENSMUSP00000142159.2; ENSMUSG00000103800.2.
DR GeneID; 353235; -.
DR KEGG; mmu:353235; -.
DR UCSC; uc008epd.2; mouse.
DR AGR; MGI:2681879; -.
DR CTD; 56140; -.
DR MGI; MGI:2681879; Pcdha8.
DR VEuPathDB; HostDB:ENSMUSG00000103800; -.
DR GeneTree; ENSGT00940000163312; -.
DR HOGENOM; CLU_006480_0_1_1; -.
DR OMA; VGHCKIL; -.
DR OrthoDB; 4259465at2759; -.
DR BioGRID-ORCS; 353235; 0 hits in 66 CRISPR screens.
DR ChiTaRS; Pcdha1; mouse.
DR Proteomes; UP000000589; Chromosome 18.
DR Bgee; ENSMUSG00000103800; Expressed in embryonic brain and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF133; PROTOCADHERIN ALPHA-9; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..946
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015099542"
FT TRANSMEM 698..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 157..242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..350
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 359..455
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 456..565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 581..678
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 758..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 101760 MW; 5E060D4A81E1076F CRC64;
MLCLGGAVPD DQLLVLSLLL IAVWEVGSGQ LHYSIPEEAK HGTFVGRIAQ DLELQLPELV
PGLFQLDSKG FGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE
VEVRDINDNP PMFPATQKAL FIPESRLLDS RFPLEGASDA DVGSNALLTY RLSTNEHFSL
DVPPNHEQVK PLGLVLRKPL DREEAAEIRL LLTATDGGKP ELTGTVQLLI TVLDVNDNAP
VFDRSLYTVK LPENVPNGSL VIKVNASDLD EGVNGDVMYS FSSDVSSDIK SKFHMDTVSG
EITVIGIIDF EESKAYKIPL EARDKGLPPL IGHCTVLVEV VDANDNAPQL NVKTLWLPVK
EDAQLGKIIA LISVIDLDSG INGQVTCSLT NHVPFKLVST FKNYYSLVLD SALDRETISN
YDVIVTARDG GSPSLLATAS VSVEVADVND NAPAFAQPEY TVFVKENNPP GAHIFTVSAV
DADAQENALV SYSLVERRVG ERLLSSYVSV HAESGKVFAL QPLDHEELEL LQFQVSARDA
GVPALGSNVT LQVFVLDEND NVPMLLGSGT GGSDGVFNQL LSRSVDPGHV VAKVRAVDAD
SGYNAWLSYE LLSWPGSMRS PFRVGLYTGE ISTTRSLDET DGTRQRLLVL VKDHGEPPLT
ATVTVLVSLV ESGQAPKTSS RSSVGVTVPE PSLVDVNVYL IIAICAVSSL LVLTLLLYTA
LRCSATPTGG ACGSGKPMLV CSSAAGTWSY SQQRRQRVCS GEGPPKTDLM AFSPGLPPCP
GSAEPSVSLD SSEKPRQPNP DWRYSASLRA GMHSSVHLEE AGILRAGPGG PDQQWPTVSS
ATPEPEAGEV SPPVGAGVNS NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPA
NNQIDKSDFI TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ
//
