ID IMP3_MOUSE Reviewed; 184 AA.
AC Q921Y2;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 24-JAN-2024, entry version 140.
DE RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP3;
DE Short=U3 snoRNP protein IMP3;
GN Name=Imp3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein
CC (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal
CC RNA processing. Part of the small subunit (SSU) processome, first
CC precursor of the small eukaryotic ribosomal subunit. During the
CC assembly of the SSU processome in the nucleolus, many ribosome
CC biogenesis factors, an RNA chaperone and ribosomal proteins associate
CC with the nascent pre-rRNA and work in concert to generate RNA folding,
CC modifications, rearrangements and cleavage as well as targeted
CC degradation of pre-ribosomal RNA by the RNA exosome.
CC {ECO:0000250|UniProtKB:Q9NV31}.
CC -!- SUBUNIT: Part of the small subunit (SSU) processome, composed of more
CC than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
CC Component of a heterotrimeric complex containing IMP3, IMP4 and
CC MPHOSPH10. Interacts with MPHOSPH10. {ECO:0000250|UniProtKB:Q9NV31}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q9NV31}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000305}.
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DR EMBL; BC009145; AAH09145.1; -; mRNA.
DR CCDS; CCDS23213.1; -.
DR RefSeq; NP_598737.1; NM_133976.2.
DR AlphaFoldDB; Q921Y2; -.
DR SMR; Q921Y2; -.
DR BioGRID; 221882; 26.
DR STRING; 10090.ENSMUSP00000034827; -.
DR PhosphoSitePlus; Q921Y2; -.
DR SwissPalm; Q921Y2; -.
DR EPD; Q921Y2; -.
DR MaxQB; Q921Y2; -.
DR PaxDb; 10090-ENSMUSP00000034827; -.
DR PeptideAtlas; Q921Y2; -.
DR ProteomicsDB; 269311; -.
DR Pumba; Q921Y2; -.
DR Antibodypedia; 43256; 275 antibodies from 30 providers.
DR DNASU; 102462; -.
DR Ensembl; ENSMUST00000034827.10; ENSMUSP00000034827.9; ENSMUSG00000032288.10.
DR GeneID; 102462; -.
DR KEGG; mmu:102462; -.
DR UCSC; uc009ptq.1; mouse.
DR AGR; MGI:1916119; -.
DR CTD; 55272; -.
DR MGI; MGI:1916119; Imp3.
DR VEuPathDB; HostDB:ENSMUSG00000032288; -.
DR eggNOG; KOG4655; Eukaryota.
DR GeneTree; ENSGT00550000075090; -.
DR HOGENOM; CLU_097281_0_0_1; -.
DR InParanoid; Q921Y2; -.
DR OMA; FRIKHEQ; -.
DR OrthoDB; 5473811at2759; -.
DR PhylomeDB; Q921Y2; -.
DR TreeFam; TF300149; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 102462; 25 hits in 73 CRISPR screens.
DR PRO; PR:Q921Y2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q921Y2; Protein.
DR Bgee; ENSMUSG00000032288; Expressed in mesodermal cell in embryo and 261 other cell types or tissues.
DR Genevisible; Q921Y2; MM.
DR GO; GO:0034457; C:Mpp10 complex; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0030684; C:preribosome; ISO:MGI.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0032040; C:small-subunit processome; ISS:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; IGI:MGI.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR InterPro; IPR022801; Ribosomal_uS4.
DR InterPro; IPR001912; Ribosomal_uS4_N.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; 30S 40S RIBOSOMAL PROTEIN; 1.
DR PANTHER; PTHR11831:SF1; U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3; 1.
DR Pfam; PF00163; Ribosomal_S4; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR PROSITE; PS50889; S4; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW RNA-binding; rRNA processing; rRNA-binding.
FT CHAIN 1..184
FT /note="U3 small nucleolar ribonucleoprotein protein IMP3"
FT /id="PRO_0000132710"
FT DOMAIN 109..175
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
SQ SEQUENCE 184 AA; 21777 MW; 5BFC2B6C600B8166 CRC64;
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREEYTRYNQ LSRAVRELAR
RLRDLPERDP FRVRASAALL DKLYAMGLVP TRGSLELCDS VSASSFCRRR LPTLLLKLRM
AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF
DLDA
//
