ID TAA8C_RAT Reviewed; 344 AA.
AC Q923Y0;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Trace amine-associated receptor 8c;
DE Short=TaR-8c;
DE Short=Trace amine receptor 8c;
DE AltName: Full=Trace amine receptor 10;
DE Short=TaR-10;
GN Name=Taar8c; Synonyms=Ta10, Tar10, Trar10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380198; AAK71249.1; -; Genomic_DNA.
DR RefSeq; NP_783190.1; NM_175600.1.
DR AlphaFoldDB; Q923Y0; -.
DR SMR; Q923Y0; -.
DR STRING; 10116.ENSRNOP00000075381; -.
DR GlyCosmos; Q923Y0; 2 sites, No reported glycans.
DR GlyGen; Q923Y0; 2 sites.
DR PaxDb; 10116-ENSRNOP00000044937; -.
DR Ensembl; ENSRNOT00055052947; ENSRNOP00055043753; ENSRNOG00055030524.
DR Ensembl; ENSRNOT00060047163; ENSRNOP00060039235; ENSRNOG00060027199.
DR Ensembl; ENSRNOT00065033164; ENSRNOP00065026529; ENSRNOG00065019687.
DR GeneID; 319105; -.
DR KEGG; rno:319105; -.
DR AGR; RGD:631390; -.
DR RGD; 631390; Taar8c.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q923Y0; -.
DR OrthoDB; 2901788at2759; -.
DR PhylomeDB; Q923Y0; -.
DR Reactome; R-RNO-375280; Amine ligand-binding receptors.
DR PRO; PR:Q923Y0; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR PANTHER; PTHR24249; HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24249:SF374; TRACE AMINE-ASSOCIATED RECEPTOR 8; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..344
FT /note="Trace amine-associated receptor 8c"
FT /id="PRO_0000070180"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..319
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 344 AA; 38016 MW; 6AB7A52CE3BEB692 CRC64;
MTSNFSQATL QLCYENVNAS CIKTPYSPGL RVLLYMVFGF GAVLAVCGNL LVVISVLHFK
QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG DTFCSLHSCC DVAFCYSSAL
HLCFISVDRY IAVTDPLVYP TKFTVSVSGI CISISWILPL VYSSAVFYTG ISAMGIENLV
SALNCVGGCQ VVVNQDWVLI SFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSVSGSKGE
SSLESHKARV AKRERKAAKT LGVTVLAFIV SWLPYTIDTL IDAFMGFITP AYVYEFCCWS
AYYNSAMNPL IYAFFYPWFR KAMKLILSGK ILKGHSSTTS LFSE
//
