ID NUSA_RICCN Reviewed; 503 AA.
AC Q92HF4;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000255|HAMAP-Rule:MF_00945};
GN Name=nusA {ECO:0000255|HAMAP-Rule:MF_00945}; OrderedLocusNames=RC0817;
OS Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=272944;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-613 / Malish 7;
RX PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
CC -!- FUNCTION: Participates in both transcription termination and
CC antitermination. {ECO:0000255|HAMAP-Rule:MF_00945}.
CC -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC dependent RNA polymerase and to nascent RNA. {ECO:0000255|HAMAP-
CC Rule:MF_00945}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00945}.
CC -!- SIMILARITY: Belongs to the NusA family. {ECO:0000255|HAMAP-
CC Rule:MF_00945}.
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DR EMBL; AE006914; AAL03355.1; -; Genomic_DNA.
DR PIR; A97802; A97802.
DR RefSeq; WP_010977426.1; NC_003103.1.
DR AlphaFoldDB; Q92HF4; -.
DR SMR; Q92HF4; -.
DR GeneID; 927779; -.
DR KEGG; rco:RC0817; -.
DR PATRIC; fig|272944.4.peg.928; -.
DR HOGENOM; CLU_029242_0_0_5; -.
DR Proteomes; UP000000816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR CDD; cd02134; KH-II_NusA_rpt1; 1.
DR CDD; cd22529; KH-II_NusA_rpt2; 1.
DR CDD; cd04455; S1_NusA; 1.
DR Gene3D; 3.30.300.20; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR HAMAP; MF_00945_B; NusA_B; 1.
DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR025249; KH_dom_NusA-like.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR030842; NusA_bac.
DR InterPro; IPR036555; NusA_N_sf.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR013735; TF_NusA_N.
DR InterPro; IPR010214; Tscrpt_termin_fac_NusA_C_rpt.
DR InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR NCBIfam; TIGR01953; NusA; 1.
DR NCBIfam; TIGR01954; nusA_Cterm_rpt; 1.
DR PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF13184; KH_5; 1.
DR Pfam; PF08529; NusA_N; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 2.
DR SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; RNA-binding; Transcription; Transcription antitermination;
KW Transcription regulation; Transcription termination.
FT CHAIN 1..503
FT /note="Transcription termination/antitermination protein
FT NusA"
FT /id="PRO_0000181976"
FT DOMAIN 139..203
FT /note="S1 motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00945"
FT DOMAIN 308..378
FT /note="KH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00945"
SQ SEQUENCE 503 AA; 56523 MW; 10EE17E5E9A79C5C CRC64;
MSNIGNVEIL QIIDSVAREK GISKEILIST VEQAVQAAGR KKYGNEYDIK AQINRKTGEI
NLLRILKIVE DVEDYLTQIS LEEALIKNPE AKIGDEIYEY LPPIDHARVS AQAAKQVITQ
RVIEAEREKQ YHDFKDRKGE IINGIVKRIE YGDIIVDLSR AEAIIKKDQL IKGENFKPND
RIKAYVQDVR QETKGPQIFL SRVDNQMLVK LFKLEVPEIL ESIIQIKSVA RDPGSKAKIA
VFAADSSIDP VGSCVGIRGN RVKAVTNELN GEKIDIVLWS NDLAQFIVNA LAPLAPGEIT
KILIDEDRHK VEVVVSQENQ SIAIGRRGQN VRLASQLTGW NIDIMTEEQE SKRRNEEFLT
STALFMEALD VEEVIGQLLS VTGFNSVEQI ASSEISTLTR IEGFEEELAV EIKNRAINYV
DLKNEKIIKK LEDLGVEQEL IDILELSLEL ILQFAEYGIK TIEDLGEMSV NEFKNLAPNS
NITDENIKLL IKTARQHGAL KDS
//
