ID Q92MD4_RHIME Unreviewed; 347 AA.
AC Q92MD4;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=NADP-dependent alcohol dehydrogenase {ECO:0000313|EMBL:CAC47271.1};
DE EC=1.1.1.2 {ECO:0000313|EMBL:CAC47271.1};
GN ORFNames=SMc00680 {ECO:0000313|EMBL:CAC47271.1};
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834 {ECO:0000313|EMBL:CAC47271.1, ECO:0000313|Proteomes:UP000001976};
RN [1] {ECO:0000313|EMBL:CAC47271.1, ECO:0000313|Proteomes:UP000001976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021 {ECO:0000313|EMBL:CAC47271.1,
RC ECO:0000313|Proteomes:UP000001976};
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [2] {ECO:0000313|Proteomes:UP000001976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021 {ECO:0000313|Proteomes:UP000001976};
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; AL591688; CAC47271.1; -; Genomic_DNA.
DR RefSeq; NP_386798.1; NC_003047.1.
DR RefSeq; WP_010970134.1; NC_003047.1.
DR AlphaFoldDB; Q92MD4; -.
DR EnsemblBacteria; CAC47271; CAC47271; SMc00680.
DR GeneID; 61604153; -.
DR KEGG; sme:SMc00680; -.
DR PATRIC; fig|266834.11.peg.4194; -.
DR eggNOG; COG1064; Bacteria.
DR HOGENOM; CLU_026673_20_2_5; -.
DR OrthoDB; 9806940at2; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAC47271.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001976};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..340
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 347 AA; 37723 MW; 8422CD96424B06AE CRC64;
MAIARGYAAT DASKPLAPFT FERREPRDDD VVIDIKYCGV CHSDIHQARD EWGNSTFPMV
PGHEIVGIVR AVGSQVTRFK IGDRVGVGCF VDSCTTCAKR DLDLEQYLPG LVVTYNGVEA
DGTPTQGGYS DHIVVKEGYV LSIPENLPLD AAAPLLCAGI TLYSPLRHWK AGPGKKVAIV
GLGGLGHMGV KLAHAMGAEV TVLSQTLSKK EDGLKLGADH YYATKDPETF TKLAGSFDLI
ICTVAAEIDW NAYLNLLKVD GELVLVGIPE NPVPVHAFSL VPARRSISGS MIGSIKETQE
MLDFCGEHGI VSEIETIRME QINEAYERVV RSDVRYRFVI DMESIKA
//