ID Q93329_CAEEL Unreviewed; 531 AA.
AC Q93329;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 2.
DT 27-MAR-2024, entry version 177.
DE SubName: Full=AcetylCholine Receptor {ECO:0000313|EMBL:CAB01685.2};
GN Name=lev-8 {ECO:0000313|EMBL:CAB01685.2,
GN ECO:0000313|WormBase:C35C5.5};
GN ORFNames=C35C5.5 {ECO:0000313|WormBase:C35C5.5}, CELE_C35C5.5
GN {ECO:0000313|EMBL:CAB01685.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB01685.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB01685.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB01685.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; BX284606; CAB01685.2; -; Genomic_DNA.
DR PIR; T19748; T19748.
DR RefSeq; NP_509932.2; NM_077531.4.
DR AlphaFoldDB; Q93329; -.
DR SMR; Q93329; -.
DR IntAct; Q93329; 1.
DR MINT; Q93329; -.
DR STRING; 6239.C35C5.5.1; -.
DR PaxDb; 6239-C35C5-5; -.
DR EnsemblMetazoa; C35C5.5.1; C35C5.5.1; WBGene00002975.
DR GeneID; 191600; -.
DR KEGG; cel:CELE_C35C5.5; -.
DR AGR; WB:WBGene00002975; -.
DR WormBase; C35C5.5; CE34160; WBGene00002975; lev-8.
DR eggNOG; KOG3645; Eukaryota.
DR HOGENOM; CLU_018074_1_3_1; -.
DR InParanoid; Q93329; -.
DR OMA; PNEHKMT; -.
DR OrthoDB; 2876949at2759; -.
DR PhylomeDB; Q93329; -.
DR Reactome; R-CEL-629587; Highly sodium permeable postsynaptic acetylcholine nicotinic receptors.
DR Reactome; R-CEL-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR Reactome; R-CEL-629597; Highly calcium permeable nicotinic acetylcholine receptors.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002975; Expressed in embryo and 4 other cell types or tissues.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19064; LGIC_TM_nAChR; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945:SF492; LEV-8; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CAB01685.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 26..531
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022247903"
FT TRANSMEM 259..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 323..346
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 482..500
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 30..258
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 267..497
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 531 AA; 60721 MW; 55E0A50F6F222C9C CRC64;
MWIPQRISHI FLLVIFILHI VTINANKHVS QLLENLLTDY NKAVRPVHNA SDALKVKFGA
NLCRLIDVDE VNQVLTTSLW LEMQWYDKKL TWNPTDWGGV EYIHIPSDQI WIPDIVLYNN
ADGEPHITIT SLAKIDHHGR VVWQPPSIYK SFCPINIKYF PYDWQTCEMK FGGWSNDGET
LDLYQIPVDV DDIPQVKRQD DGVEFLYLEK GLGLSFYHES AEWDLLSATS SRYAQIYPGC
CGQQYYIDIK YRIIIRRKAI FFTVTLTIPC MLIANVTPFV FLILPNEHKM TYSISVLVAF
SVFYLVLIDL IPPTSLSLSL IGIYLLFTLL MVSVSIILSV VTINMYRKQA FSSGMSHWQR
WLFVQRLPKL LRLKTLEHTL GPDEGSETTT PRTGSVSVTA SVTQRTLNPN NNSPVFPPQR
LRLLSLVQMD EALKQRCAAD NLDLFRKIAG HLKIISAHFH NQQMEGKITE EWQLMSLVID
RIFLILFLAV SMAANIMFVY NSPTLFDDRP SLVPSVAHKP LSGGTINVLN T
//
