ID Q93338_CAEEL Unreviewed; 282 AA.
AC Q93338;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 2.
DT 27-MAR-2024, entry version 176.
DE SubName: Full=DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein {ECO:0000313|EMBL:CAB02268.2};
GN Name=rpb-3 {ECO:0000313|EMBL:CAB02268.2,
GN ECO:0000313|WormBase:C36B1.3};
GN ORFNames=C36B1.3 {ECO:0000313|WormBase:C36B1.3}, CELE_C36B1.3
GN {ECO:0000313|EMBL:CAB02268.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB02268.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB02268.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB02268.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase
CC subunit family. {ECO:0000256|ARBA:ARBA00025804}.
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DR EMBL; BX284601; CAB02268.2; -; Genomic_DNA.
DR PIR; T19774; T19774.
DR RefSeq; NP_492361.2; NM_059960.5.
DR AlphaFoldDB; Q93338; -.
DR SMR; Q93338; -.
DR STRING; 6239.C36B1.3.1; -.
DR EPD; Q93338; -.
DR PaxDb; 6239-C36B1-3; -.
DR PeptideAtlas; Q93338; -.
DR EnsemblMetazoa; C36B1.3.1; C36B1.3.1; WBGene00007971.
DR GeneID; 172680; -.
DR KEGG; cel:CELE_C36B1.3; -.
DR UCSC; C36B1.3; c. elegans.
DR AGR; WB:WBGene00007971; -.
DR WormBase; C36B1.3; CE39091; WBGene00007971; rpb-3.
DR eggNOG; KOG1522; Eukaryota.
DR GeneTree; ENSGT00950000183100; -.
DR HOGENOM; CLU_038421_1_0_1; -.
DR InParanoid; Q93338; -.
DR OMA; PENIVMM; -.
DR OrthoDB; 5472982at2759; -.
DR PhylomeDB; Q93338; -.
DR Reactome; R-CEL-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-CEL-113418; Formation of the Early Elongation Complex.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-CEL-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-CEL-6803529; FGFR2 alternative splicing.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-72086; mRNA Capping.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR Reactome; R-CEL-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR Reactome; R-CEL-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-CEL-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-CEL-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-CEL-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-CEL-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-CEL-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00007971; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005665; C:RNA polymerase II, core complex; IBA:GO_Central.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:GOC.
DR CDD; cd07031; RNAP_II_RPB3; 1.
DR Gene3D; 2.170.120.12; DNA-directed RNA polymerase, insert domain; 1.
DR Gene3D; 3.30.1360.10; RNA polymerase, RBP11-like subunit; 1.
DR HAMAP; MF_00320; RNApol_arch_Rpo3; 1.
DR InterPro; IPR011262; DNA-dir_RNA_pol_insert.
DR InterPro; IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3.
DR InterPro; IPR036603; RBP11-like.
DR InterPro; IPR022842; RNAP_Rpo3/Rpb3/RPAC1.
DR InterPro; IPR036643; RNApol_insert_sf.
DR PANTHER; PTHR11800; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR11800:SF2; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3; 1.
DR Pfam; PF01000; RNA_pol_A_bac; 1.
DR Pfam; PF01193; RNA_pol_L; 1.
DR SMART; SM00662; RPOLD; 1.
DR SUPFAM; SSF56553; Insert subdomain of RNA polymerase alpha subunit; 1.
DR SUPFAM; SSF55257; RBP11-like subunits of RNA polymerase; 1.
PE 1: Evidence at protein level;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000313|EMBL:CAB02268.2};
KW Proteomics identification {ECO:0007829|EPD:Q93338,
KW ECO:0007829|PeptideAtlas:Q93338};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 18..270
FT /note="DNA-directed RNA polymerase RpoA/D/Rpb3-type"
FT /evidence="ECO:0000259|SMART:SM00662"
FT REGION 208..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 282 AA; 32378 MW; 207E2B0316EEB984 CRC64;
MPYANQPNIE VTELTNDIIK FVLWDTDLSV ANSLRRVFMA EVPTIAIDWV QIETNTSVLH
DEFIAHRMGL IPFISDYHVE KMQYTRDCEC AEFCDECSIP FILQMKCKDE ATLAVTTEHL
MPMHNLDTTV RPACGKALRE RGSTRDEFHN REEILIVKLR KGQELNLKAY VKKGFGKEHA
KWNPTCGVAF EYDPDNALRH TIYPNVEEWP RSDHSSLPED STEKEAPFEP DNKPNKFWFS
IEGTGALPAQ RIVTMGIGIL KRKLEELNMA LSNELQAHAQ QQ
//
