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Database: UniProt
Entry: Q93560
LinkDB: Q93560
Original site: Q93560 
ID   BLMP1_CAEEL             Reviewed;         817 AA.
AC   Q93560; B7WN98;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   13-FEB-2019, entry version 158.
DE   RecName: Full=B lymphocyte-induced maturation protein 1 homolog {ECO:0000312|WormBase:F25D7.3a};
GN   Name=blmp-1 {ECO:0000312|WormBase:F25D7.3a};
GN   ORFNames=F25D7.3 {ECO:0000312|WormBase:F25D7.3a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|EMBL:CAB01695.1};
RN   [1] {ECO:0000312|EMBL:CAB01695.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
RP   SPLICING.
RC   STRAIN=Bristol N2 {ECO:0000312|EMBL:CAB01695.1};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH DRE-1, DEVELOPMENTAL STAGE, UBIQUITINATION,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=24613396; DOI=10.1016/j.devcel.2014.01.028;
RA   Horn M., Geisen C., Cermak L., Becker B., Nakamura S., Klein C.,
RA   Pagano M., Antebi A.;
RT   "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C.
RT   elegans developmental timing and maturation.";
RL   Dev. Cell 28:697-710(2014).
RN   [3] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH DRE-1, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=24968003; DOI=10.1371/journal.pgen.1004428;
RA   Huang T.F., Cho C.Y., Cheng Y.T., Huang J.W., Wu Y.Z., Yeh A.Y.,
RA   Nishiwaki K., Chang S.C., Wu Y.C.;
RT   "BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in
RT   C. elegans.";
RL   PLoS Genet. 10:E1004428-E1004428(2014).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26234645; DOI=10.1016/j.bbagrm.2015.07.012;
RA   Yang J., Fong H.T., Xie Z., Tan J.W., Inoue T.;
RT   "Direct and positive regulation of Caenorhabditis elegans bed-3 by
RT   PRDM1/BLIMP1 ortholog BLMP-1.";
RL   Biochim. Biophys. Acta 1849:1229-1236(2015).
CC   -!- FUNCTION: Transcription factor which binds to enhancer elements in
CC       the promoter region of genes (PubMed:26234645). Regulates the
CC       expression of the transcription factor bed-3 to control vulval
CC       development (PubMed:26234645). Promotes terminal differentiation
CC       in the hypodermis and is involved in regulation of gonadal
CC       outgrowth and entry into the dauer stage (PubMed:24613396).
CC       Regulates the timing of dorsalward migration of the distal tip
CC       cells of the hermaphrodite gonad by inhibiting precocious unc-5
CC       and lin-29 expression which in turn prevents early dorsalward
CC       turning (PubMed:24968003). {ECO:0000269|PubMed:24613396,
CC       ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:26234645}.
CC   -!- SUBUNIT: Interacts with dre-1; the interaction targets blmp-1 for
CC       proteasomal degradation. {ECO:0000269|PubMed:24613396,
CC       ECO:0000269|PubMed:24968003}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24968003}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000312|WormBase:F25D7.3a};
CC         IsoId=Q93560-1; Sequence=Displayed;
CC         Note=No experimental confirmation available. {ECO:0000305};
CC       Name=2 {ECO:0000312|WormBase:F25D7.3b};
CC         IsoId=Q93560-2; Sequence=VSP_057061;
CC         Note=No experimental confirmation available. {ECO:0000305};
CC   -!- TISSUE SPECIFICITY: Expressed in hypodermal, vulval, intestinal
CC       and distal tip cells. {ECO:0000269|PubMed:24968003}.
CC   -!- DEVELOPMENTAL STAGE: In distal tip cells, expressed from mid-L2
CC       when gonadal outgrowth initiates (PubMed:24613396). By mid-L3,
CC       just prior to the dorsal gonadal turn, levels drop dramatically
CC       (PubMed:24968003). In seam and hypodermal cells, levels are
CC       largely constant throughout larval development except for a
CC       transient peak early in L4 (PubMed:24613396).
CC       {ECO:0000269|PubMed:24613396, ECO:0000269|PubMed:24968003}.
CC   -!- PTM: Ubiquitinated by the SCF(dre-1) complex, leading to its
CC       degradation by the proteasome. {ECO:0000269|PubMed:24613396}.
CC   -!- DISRUPTION PHENOTYPE: Gonadal migration defects with premature
CC       dorsal turning of distal tip cells in the hermaphrodite gonad
CC       (PubMed:24613396, PubMed:24968003). Defective dauer formation,
CC       shortened lifespan and retarded terminal differentiation of seam
CC       cells with incomplete adult alae synthesis (PubMed:24613396).
CC       Suppresses the precocious seam cell terminal differentiation and
CC       gonadal migration defects seen in dre-1 mutants (PubMed:24613396).
CC       Weak dumpy phenotype and partially penetrant embryonic lethality
CC       (PubMed:24968003). Reduced expression of the transcription factor
CC       bed-3 which is involved in vulval development and failed division
CC       of vulval precursor cell descendents (PubMed:26234645).
CC       {ECO:0000269|PubMed:24613396, ECO:0000269|PubMed:24968003,
CC       ECO:0000269|PubMed:26234645}.
DR   EMBL; Z78418; CAB01695.1; -; Genomic_DNA.
DR   EMBL; Z78418; CAV31771.1; -; Genomic_DNA.
DR   PIR; T21336; T21336.
DR   RefSeq; NP_001251370.1; NM_001264441.1. [Q93560-1]
DR   RefSeq; NP_001251371.1; NM_001264442.1. [Q93560-2]
DR   UniGene; Cel.18891; -.
DR   ProteinModelPortal; Q93560; -.
DR   SMR; Q93560; -.
DR   BioGrid; 38333; 1.
DR   IntAct; Q93560; 12.
DR   STRING; 6239.F25D7.3a; -.
DR   EPD; Q93560; -.
DR   PaxDb; Q93560; -.
DR   EnsemblMetazoa; F25D7.3a; F25D7.3a; WBGene00003847. [Q93560-1]
DR   EnsemblMetazoa; F25D7.3b; F25D7.3b; WBGene00003847. [Q93560-2]
DR   GeneID; 172917; -.
DR   KEGG; cel:CELE_F25D7.3; -.
DR   UCSC; F25D7.3; c. elegans. [Q93560-1]
DR   CTD; 172917; -.
DR   WormBase; F25D7.3a; CE09631; WBGene00003847; blmp-1. [Q93560-1]
DR   WormBase; F25D7.3b; CE43409; WBGene00003847; blmp-1. [Q93560-2]
DR   eggNOG; KOG2461; Eukaryota.
DR   eggNOG; ENOG410ZFVU; LUCA.
DR   GeneTree; ENSGT00940000154798; -.
DR   HOGENOM; HOG000016658; -.
DR   InParanoid; Q93560; -.
DR   OMA; KTRYACK; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q93560; -.
DR   PRO; PR:Q93560; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00003847; Expressed in 4 organ(s), highest expression level in multi-cellular organism.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0001158; F:enhancer sequence-specific DNA binding; IDA:WormBase.
DR   GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR   GO; GO:0043053; P:dauer entry; IMP:UniProtKB.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR   GO; GO:0040035; P:hermaphrodite genitalia development; IMP:UniProtKB.
DR   GO; GO:1903355; P:negative regulation of distal tip cell migration; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0045684; P:positive regulation of epidermis development; IMP:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Developmental protein;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN         1    817       B lymphocyte-induced maturation protein 1
FT                                homolog. {ECO:0000305}.
FT                                /FTId=PRO_0000430670.
FT   DOMAIN      103    241       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     508    530       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     536    558       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     564    586       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     592    614       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     620    642       C2H2-type 5; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   COMPBIAS     16     59       Ser-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00016}.
FT   COMPBIAS    712    793       Gln-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00006}.
FT   VAR_SEQ     685    700       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:9851916}.
FT                                /FTId=VSP_057061.
SQ   SEQUENCE   817 AA;  88639 MW;  4B74F5263A9594FA CRC64;
     MGQGSGDDGV PPAPFSSAAA AAHSPPHSPL SVGVSSASSA TSSSSTPPSS TSPAGVSASG
     ARNVETDWKQ SGDENLAELC IFHVPDKSVS LPNPKRAECT LPMNLILKSS SKNRKKSSIW
     SSDHIPRGVR FGPLVGEIRL VDVDTALVCP AEASMAGGGP AQEDVPFDEA PEEWKIYSPS
     GGRLNKTICV KDDARSNWMK YVAAAEEEDF QNLVAAQIGN DIYFYTVKKI EANTELSFWF
     SRDYARKLNY STRPYVRVRR PATQLIPSAP PASASTAIAS LAETIVAIDY SVKKLIESPI
     DTLSTDASSA SDEEMIDVEE QESCTRPVAE VTRPNVIQNP VVRPVATKVN NFPGIPVRLG
     NFYASPLVDF KEFMRKSLQL KLVDTSMFVS PVAQTTAAIT ATGGRSGQPI DVQPVLAATA
     GAHFGNYAAI YGSQDFQHEL SKPLYTSASP AFGGGGGMGG GFGMGGSAHT SSFHQLPFVN
     HSSSSHNDSS FNGVPNYVQQ QENGKTRYAC KDCNKTFGQL SNLKVHVRTH TGERPFKCEI
     CTKEFTQLAH LQKHHLVHTG ERPHRCDICD KRFSSTSNLK THLRLHNGQK PYTCDVCDAK
     FTQYVHLRLH KRLHANERPY SCGTCGKKYI SPSGLRTHWK TTTCKEEDMK DSMRDDLMDI
     KGEIDEGSMS GSGYGNLGIF ENTLNSELKR PLMPIETIYS KYNLPNASLL GQGPSGMQEQ
     QAPPPTSQQQ QHMMYGNTMG HMGQGSHLQG PPPPPQHFQM DHSGMQNGGG IPHQHQLIQG
     GPSSGSGQQQ HPQHNGIHRL PDLKNPLLPS LGLPHYP
//
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