GenomeNet

Database: UniProt
Entry: Q93Z38
LinkDB: Q93Z38
Original site: Q93Z38 
ID   TAR4_ARATH              Reviewed;         463 AA.
AC   Q93Z38; Q9FX14;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   16-JAN-2019, entry version 84.
DE   RecName: Full=Tryptophan aminotransferase-related protein 4;
DE            EC=2.6.1.-;
GN   Name=TAR4; OrderedLocusNames=At1g34060;
GN   ORFNames=F12G12.12, F12G12.150;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA   White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA   Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA   Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA   Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA   Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA   Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA   Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA   Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA   Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA   Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA   Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA   Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA   Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA   Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18394997; DOI=10.1016/j.cell.2008.01.047;
RA   Stepanova A.N., Robertson-Hoyt J., Yun J., Benavente L.M., Xie D.Y.,
RA   Dolezal K., Schlereth A., Juergens G., Alonso J.M.;
RT   "TAA1-mediated auxin biosynthesis is essential for hormone crosstalk
RT   and plant development.";
RL   Cell 133:177-191(2008).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18394996; DOI=10.1016/j.cell.2008.01.049;
RA   Tao Y., Ferrer J.L., Ljung K., Pojer F., Hong F., Long J.A., Li L.,
RA   Moreno J.E., Bowman M.E., Ivans L.J., Cheng Y., Lim J., Zhao Y.,
RA   Ballare C.L., Sandberg G., Noel J.P., Chory J.;
RT   "Rapid synthesis of auxin via a new tryptophan-dependent pathway is
RT   required for shade avoidance in plants.";
RL   Cell 133:164-176(2008).
CC   -!- FUNCTION: Probable aminotransferase.
CC       {ECO:0000250|UniProtKB:Q9S7N2}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250|UniProtKB:Q9S7N2};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alliinase family. {ECO:0000305}.
DR   EMBL; AC015446; AAG12531.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE31667.1; -; Genomic_DNA.
DR   EMBL; AY058162; AAL25576.1; -; mRNA.
DR   PIR; E86464; E86464.
DR   RefSeq; NP_564435.1; NM_103128.4.
DR   UniGene; At.26614; -.
DR   ProteinModelPortal; Q93Z38; -.
DR   SMR; Q93Z38; -.
DR   STRING; 3702.AT1G34060.1; -.
DR   PaxDb; Q93Z38; -.
DR   EnsemblPlants; AT1G34060.1; AT1G34060.1; AT1G34060.
DR   GeneID; 840303; -.
DR   Gramene; AT1G34060.1; AT1G34060.1; AT1G34060.
DR   KEGG; ath:AT1G34060; -.
DR   Araport; AT1G34060; -.
DR   TAIR; locus:2009031; AT1G34060.
DR   eggNOG; ENOG410IIDZ; Eukaryota.
DR   eggNOG; ENOG410XS9Z; LUCA.
DR   HOGENOM; HOG000237549; -.
DR   InParanoid; Q93Z38; -.
DR   OrthoDB; 544719at2759; -.
DR   PhylomeDB; Q93Z38; -.
DR   PRO; PR:Q93Z38; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q93Z38; baseline and differential.
DR   Genevisible; Q93Z38; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.25.30; -; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR006948; Alliinase_C.
DR   InterPro; IPR037029; Alliinase_N_sf.
DR   InterPro; IPR006947; EGF_alliinase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_dom1.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   Pfam; PF04864; Alliinase_C; 1.
DR   Pfam; PF04863; EGF_alliinase; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   2: Evidence at transcript level;
KW   Aminotransferase; Complete proteome; Membrane; Pyridoxal phosphate;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN         1    463       Tryptophan aminotransferase-related
FT                                protein 4.
FT                                /FTId=PRO_0000411677.
FT   TRANSMEM      6     26       Helical. {ECO:0000255}.
FT   REGION      163    164       Pyridoxal phosphate binding.
FT                                {ECO:0000250|UniProtKB:Q9S7N2}.
FT   REGION      259    262       Pyridoxal phosphate binding.
FT                                {ECO:0000250|UniProtKB:Q9S7N2}.
FT   REGION      282    285       Pyridoxal phosphate binding.
FT                                {ECO:0000250|UniProtKB:Q9S7N2}.
FT   BINDING     124    124       Pyridoxal phosphate.
FT                                {ECO:0000250|UniProtKB:Q9S7N2}.
FT   BINDING     239    239       Pyridoxal phosphate.
FT                                {ECO:0000250|UniProtKB:Q9S7N2}.
FT   BINDING     293    293       Pyridoxal phosphate.
FT                                {ECO:0000250|UniProtKB:Q9S7N2}.
FT   MOD_RES     285    285       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000255}.
FT   CONFLICT    100    100       F -> S (in Ref. 3; AAL25576).
FT                                {ECO:0000305}.
SQ   SEQUENCE   463 AA;  52430 MW;  AB0FD34E580AD0BA CRC64;
     MMQKKLLLIV SIILNLVFTI HILYYSSTTW NPTWTNRAAA EAETVASFSC SGHGRAFVDG
     LGVLDGQKPP CECNNCYIGK DCSVLLKDCP VDANSGDPLF LEPFWMRQAE RSAILVSGWH
     RMSYIYEDGT YVSRELEKVI RKLHSVVGNA VTDNRFVIFG SGTTQLLAAA VHALSLTNSS
     VSSPARLLTS IPYYAMYKDQ AEFFDSAHLK FEGNASAWKQ SGRNDNITQV IEVVTSPNNP
     DGKLKRAVLD GPNVKTLHDY AYYWPHFSPI THPVDEDLSL FSLSKTTGHA GSRFGWGLVK
     DKAIYEKMDR FIRLTSMGVS KETQLHVLQL LKVVVGDGGN EIFSFGYGTV KKRWETLNKI
     FSMSTRFSLQ TIKPEYCNYF KKVREFTPSY AWVKCERPED TNCYEIFRAA KITGRNGNVF
     GSEERFVRLS LIRSQDDFDQ LIAMLKKLVY HEEDVPSENF MYI
//
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