ID Q94046_CAEEL Unreviewed; 1074 AA.
AC Q94046;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 01-FEB-1997, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE SubName: Full=BRCT domain-containing protein {ECO:0000313|EMBL:CAB03354.1};
GN Name=pis-1 {ECO:0000313|EMBL:CAB03354.1,
GN ECO:0000313|WormBase:T13F2.3a};
GN ORFNames=CELE_T13F2.3 {ECO:0000313|EMBL:CAB03354.1}, T13F2.3
GN {ECO:0000313|WormBase:T13F2.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB03354.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB03354.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB03354.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CAB03354.1; -; Genomic_DNA.
DR PIR; T24877; T24877.
DR RefSeq; NP_501749.1; NM_069348.5.
DR AlphaFoldDB; Q94046; -.
DR SMR; Q94046; -.
DR IntAct; Q94046; 2.
DR EPD; Q94046; -.
DR PeptideAtlas; Q94046; -.
DR EnsemblMetazoa; T13F2.3a.1; T13F2.3a.1; WBGene00004031.
DR GeneID; 177818; -.
DR KEGG; cel:CELE_T13F2.3; -.
DR UCSC; T13F2.3a; c. elegans.
DR AGR; WB:WBGene00004031; -.
DR WormBase; T13F2.3a; CE13623; WBGene00004031; pis-1.
DR HOGENOM; CLU_010214_0_0_1; -.
DR OrthoDB; 2880892at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004031; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; Q94046; baseline and differential.
DR GO; GO:0044666; C:MLL3/4 complex; IBA:GO_Central.
DR CDD; cd00027; BRCT; 1.
DR CDD; cd17717; BRCT_DNA_ligase_IV_rpt2; 1.
DR CDD; cd17730; BRCT_PAXIP1_rpt4; 1.
DR CDD; cd18432; BRCT_PAXIP1_rpt6_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 4.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR23196:SF1; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; 1.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR Pfam; PF00533; BRCT; 2.
DR Pfam; PF16589; BRCT_2; 1.
DR SMART; SM00292; BRCT; 4.
DR SUPFAM; SSF52113; BRCT domain; 3.
DR PROSITE; PS50172; BRCT; 4.
PE 1: Evidence at protein level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:Q94046,
KW ECO:0007829|PeptideAtlas:Q94046};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 528..605
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 620..694
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 844..909
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 930..1029
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..283
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..313
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1074 AA; 120339 MW; F52E142322610C50 CRC64;
MADPLSKEED IQHRPDSPPL GLLDPSRIQN PLANDQLHQV PQQQNPSGFV MPEQPRQQPP
PQTWQRTPTM SPANIFQGGS GTPGSQRSST GTPNHQMGNP PQHQQQQFFH GESPAHSQGT
PMTPQSAGMP GSNCGTPQSA GGPPTSVPYD YQQAQMQQQQ HAQAMAAAAA AQQQQQQHLQ
QQQYAQNPQQ MHDSPYRQHQ MMQMHQHPGH PSQYPPGYPQ QQAAQWQQQM YARQAAAQAQ
AQAQAQAQAQ AQQRAAAQRV PVPYPPGAYP PGMPGPMTPG YPAQAPAAPR TTPGSAGPGT
GPPGTPQRPQ YPQGTNPQPQ QAQFTYPPTQ QMTPTGQPPG YPGMPGTPTF SSPAHQMFRQ
GQPTAPPGMR QYISPQAGQQ QPTPGTPHRF APPGPSGTTS SPHFAPGAPG ADLRSPSLMS
PNQQSQQHTP VLPRSLHNEM TSHGMRPIAL PSQPLPQTQG TPQPILSASS LPPQSAGATQ
FVYRPQQPNQ MNTMNQMNQM HHDVNPFPIQ MNVDPELYLT GIHFHCFDSE KLFEDKLDRK
NLEFMIKYHG GDIEFEASKF HERIHQITHV LVDSCRNTNV MTSLEHRKRI VSIQWIIDVM
ERERVELPWR IAHLPPPFNE NFRPYLGKLF SLSGFDSSER AAISFMAEMM GAKITPFLAR
QNDLLIAKQP ADKVTRAQEW KVPVVNFQWI ADAYVCDEAS PQKRPNVENP RYQLENPVMT
NVNTSPNHIE GASQEFGAMM SCWKSQTIIA DQAYEKARQN RKTLQNNTFF FPSKRLSDQA
VAPTEDEIKS SRARLDEIKT HWEEHQEKMK DTPLSKEFYR VREPQARVSA WFGEGIDDEA
LTILKKKLEF LGGECVEKIR DATHVILISG RRSLVLLESI IRGKNIMDPE WIVDSYKQKM
WLDTLDYFLH DKELEKEFAY NCKRSVLRAR NKPVFEDIEF HVTRFVEPNQ NDLVRLIELG
GGNVHSEKPD PKYLAKCVET EQPFIIISCE NDARFLSYLA GSKLPIYNVD LVLFAMLRQQ
IEPLPQYRIP IPIVVKTPVF RQPPPYTAPP KDQEPAASLA SEPTRAADVL SENS
//
