ID Q946Y1_GOSAR Unreviewed; 520 AA.
AC Q946Y1;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
GN ORFNames=F383_21613 {ECO:0000313|EMBL:KHG00710.1};
OS Gossypium arboreum (Tree cotton) (Gossypium nanking).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29729 {ECO:0000313|EMBL:AAK73021.1};
RN [1] {ECO:0000313|EMBL:AAK73021.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11443131; DOI=10.1074/jbc.M104952200;
RA Leipelt M., Warnecke D., Zahringer U., Ott C., Muller F., Hube B.,
RA Heinz E.;
RT "Glucosylceramide synthases, a gene family responsible for the biosynthesis
RT of glucosphingolipids in animals, plants, and fungi.";
RL J. Biol. Chem. 276:33621-33629(2001).
RN [2] {ECO:0000313|EMBL:KHG00710.1}
RP NUCLEOTIDE SEQUENCE.
RA Mudge J., Ramaraj T., Lindquist I.E., Bharti A.K., Sundararajan A.,
RA Cameron C.T., Woodward J.E., May G.D., Brubaker C., Broadhvest J.,
RA Wilkins T.A.;
RT "G. arboreum L. cv. AKA8401 A2 genome assembly version 1.0.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000032142}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. AKA8401 {ECO:0000313|Proteomes:UP000032142};
RA Mudge J., Ramaraj T., Lindquist I.E., Bharti A.K., Sundararajan A.,
RA Cameron C.T., Woodward J.E., May G.D., Brubaker C., Broadhvest J.,
RA Wilkins T.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; AF367245; AAK73021.1; -; mRNA.
DR EMBL; JRRC01145636; KHG00710.1; -; Genomic_DNA.
DR RefSeq; NP_001316977.1; NM_001330048.1.
DR GeneID; 108484033; -.
DR OMA; TIVHANW; -.
DR OrthoDB; 444471at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000032142; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000032142};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAK73021.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 520 AA; 58617 MW; CDB77062770BE715 CRC64;
MSAALDPVDW LLFSLSKAFR SPLAVFVQIQ GCVICLTLAI GWAFAAYVRN REINRMKDAM
KCGNSFAFLC HDINELEHTN QVNLPRVTVV MPLKGFGEHN LHNWKSQITS LYGGPLEFLF
VVESTEDPAY HAVSRLIRDF KDDVDAKIIV AGLSTTCSQK IHNQLVGVER MHKDTKYVLF
LDDDVRLHPG SIGALTAEME KNPEIFIQTG YPLDLPSGSL GSYCIYEYHM PCSMGFATGG
KTFFLWGGCM MMQADDFRRD NYGVVSGLRD GGYSDDMTLA AIAGAHKRLI TSPPVAVFPH
PLASDLSFSR YWNYLRKQTF VLESYISRVN WLMNRGLFSF HCYLSWGFVA PYFMAAVHIA
AALQIYIKGY SYEETTCTTS GLLLASCLAI CTLTELLSMW NLTRIEVQLC NMLSPEAPKL
SLDYYNWSLI FVALLVDNFL YPISAFRSHF SQSINWSGIR YHLKNGKINK IERNKGRGPK
FTDLGGKHLY GKKGAPPKAS FLSSLARSLC QWHQPKKYEV
//
