ID Q94R73_TRICA Unreviewed; 571 AA.
AC Q94R73;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 24-JAN-2024, entry version 105.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|ARBA:ARBA00021096, ECO:0000256|RuleBase:RU003404};
DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003404};
DE Flags: Fragment;
GN Name=NADH5 {ECO:0000313|EMBL:CAC51706.1};
OS Tribolium castaneum (Red flour beetle).
OG Mitochondrion {ECO:0000313|EMBL:CAC51706.1}.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:CAC51706.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:CAC51706.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|Proteomes:UP000007266};
RX PubMed=12644407; DOI=10.1016/S1055-7903(02)00335-4;
RA Friedrich M., Muqim N.;
RT "Sequence and phylogenetic analysis of the complete mitochondrial genome of
RT the flour beetle Tribolium castanaeum.";
RL Mol. Phylogenet. Evol. 26:502-512(2003).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003257}.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000256|RuleBase:RU003404}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000766,
CC ECO:0000256|RuleBase:RU003404};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family.
CC {ECO:0000256|RuleBase:RU003404}.
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DR EMBL; AJ312413; CAC51706.1; -; Genomic_DNA.
DR RefSeq; NP_203162.1; NC_003081.2.
DR AlphaFoldDB; Q94R73; -.
DR STRING; 7070.Q94R73; -.
DR GeneID; 803820; -.
DR KEGG; tca:803820; -.
DR CTD; 4540; -.
DR InParanoid; Q94R73; -.
DR OrthoDB; 1463698at2759; -.
DR Proteomes; UP000007266; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR InterPro; IPR010934; NADH_DH_su5_C.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR PANTHER; PTHR42829:SF2; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR Pfam; PF06455; NADH5_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
DR PRINTS; PR01435; NPOXDRDTASE5.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003404};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU003404};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW NAD {ECO:0000256|RuleBase:RU003404};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003404};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003404}; Transport {ECO:0000256|RuleBase:RU003404};
KW Ubiquinone {ECO:0000256|ARBA:ARBA00023075, ECO:0000256|RuleBase:RU003404}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 84..103
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 150..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 178..196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 270..288
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 418..442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 491..512
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 553..570
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT DOMAIN 42..88
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 105..384
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 391..571
FT /note="NADH dehydrogenase subunit 5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06455"
FT NON_TER 571
FT /evidence="ECO:0000313|EMBL:CAC51706.1"
SQ SEQUENCE 571 AA; 65080 MW; 13D461CE1129D5B9 CRC64;
MIHICLIFSG LFLFWSTVFF LFSIYFIVEG LTWFLEFNLL MINSSSIVMT LLFDWMTFLF
MSFVLFISSM VIFYSREYMA SDIFINRFIM LVVMFVFSMM FLIVSPNLIS ILLGWDGLGL
VSYCLVIYYQ NVKSFNAGML TALSNRIGDV ALLMAIAWMV NYGSWNYVFY LFQLKGDSYM
NVISYLVVLA ALTKSAQIPF SSWLPAAMAA PTPVSSLVHS STLVTAGVYL LIRFNFCFNE
WLMYFLLFIS SMTMFMSGLG ASFEFDLKKI IALSTLSQLG LMMMILSLGS YELAFFHLLT
HALFKALLFM CAGNIIHSVG DFQDIRYMGG LVKFLPLTCV NFNISNLSLC GLPFLSGFYS
KDLVAEIMSM GYLSFYIYLI FYVSIGLTVC YSFRLVYYSF VGSFNFLSLN SVYEGSVMMI
KGMGGLIFLV IFMGSSLSWI IFPYPYVIIL PLFMKILTLL MVILGAWIGY ELSKFFISYD
SLSLKNYGLS WFLSNMWNMP VISTLGINYY PIIGGSFLYK SLDQGWSEVL GSQGIYSVIV
SGSKISQIFM NNSIKIFFVL MIVWLMIIFM I
//