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Database: UniProt
Entry: Q94R73_TRICA
LinkDB: Q94R73_TRICA
Original site: Q94R73_TRICA 
ID   Q94R73_TRICA            Unreviewed;       571 AA.
AC   Q94R73;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 105.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|ARBA:ARBA00021096, ECO:0000256|RuleBase:RU003404};
DE            EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003404};
DE   Flags: Fragment;
GN   Name=NADH5 {ECO:0000313|EMBL:CAC51706.1};
OS   Tribolium castaneum (Red flour beetle).
OG   Mitochondrion {ECO:0000313|EMBL:CAC51706.1}.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:CAC51706.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:CAC51706.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|Proteomes:UP000007266};
RX   PubMed=12644407; DOI=10.1016/S1055-7903(02)00335-4;
RA   Friedrich M., Muqim N.;
RT   "Sequence and phylogenetic analysis of the complete mitochondrial genome of
RT   the flour beetle Tribolium castanaeum.";
RL   Mol. Phylogenet. Evol. 26:502-512(2003).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|ARBA:ARBA00003257}.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000256|RuleBase:RU003404}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000766,
CC         ECO:0000256|RuleBase:RU003404};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004448}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family.
CC       {ECO:0000256|RuleBase:RU003404}.
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DR   EMBL; AJ312413; CAC51706.1; -; Genomic_DNA.
DR   RefSeq; NP_203162.1; NC_003081.2.
DR   AlphaFoldDB; Q94R73; -.
DR   STRING; 7070.Q94R73; -.
DR   GeneID; 803820; -.
DR   KEGG; tca:803820; -.
DR   CTD; 4540; -.
DR   InParanoid; Q94R73; -.
DR   OrthoDB; 1463698at2759; -.
DR   Proteomes; UP000007266; Mitochondrion.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   InterPro; IPR001516; Proton_antipo_N.
DR   PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR   PANTHER; PTHR42829:SF2; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   Pfam; PF00662; Proton_antipo_N; 1.
DR   PRINTS; PR01434; NADHDHGNASE5.
DR   PRINTS; PR01435; NPOXDRDTASE5.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003404};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|RuleBase:RU003404};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   NAD {ECO:0000256|RuleBase:RU003404};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003404};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003404}; Transport {ECO:0000256|RuleBase:RU003404};
KW   Ubiquinone {ECO:0000256|ARBA:ARBA00023075, ECO:0000256|RuleBase:RU003404}.
FT   TRANSMEM        12..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        84..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        178..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        217..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        242..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        270..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        294..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        375..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        418..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        448..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        491..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   TRANSMEM        553..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003404"
FT   DOMAIN          42..88
FT                   /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00662"
FT   DOMAIN          105..384
FT                   /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT                   subunit"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
FT   DOMAIN          391..571
FT                   /note="NADH dehydrogenase subunit 5 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06455"
FT   NON_TER         571
FT                   /evidence="ECO:0000313|EMBL:CAC51706.1"
SQ   SEQUENCE   571 AA;  65080 MW;  13D461CE1129D5B9 CRC64;
     MIHICLIFSG LFLFWSTVFF LFSIYFIVEG LTWFLEFNLL MINSSSIVMT LLFDWMTFLF
     MSFVLFISSM VIFYSREYMA SDIFINRFIM LVVMFVFSMM FLIVSPNLIS ILLGWDGLGL
     VSYCLVIYYQ NVKSFNAGML TALSNRIGDV ALLMAIAWMV NYGSWNYVFY LFQLKGDSYM
     NVISYLVVLA ALTKSAQIPF SSWLPAAMAA PTPVSSLVHS STLVTAGVYL LIRFNFCFNE
     WLMYFLLFIS SMTMFMSGLG ASFEFDLKKI IALSTLSQLG LMMMILSLGS YELAFFHLLT
     HALFKALLFM CAGNIIHSVG DFQDIRYMGG LVKFLPLTCV NFNISNLSLC GLPFLSGFYS
     KDLVAEIMSM GYLSFYIYLI FYVSIGLTVC YSFRLVYYSF VGSFNFLSLN SVYEGSVMMI
     KGMGGLIFLV IFMGSSLSWI IFPYPYVIIL PLFMKILTLL MVILGAWIGY ELSKFFISYD
     SLSLKNYGLS WFLSNMWNMP VISTLGINYY PIIGGSFLYK SLDQGWSEVL GSQGIYSVIV
     SGSKISQIFM NNSIKIFFVL MIVWLMIIFM I
//
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