ID Q95QF9_CAEEL Unreviewed; 624 AA.
AC Q95QF9;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE RecName: Full=Sulfhydryl oxidase {ECO:0000256|RuleBase:RU371123};
DE EC=1.8.3.2 {ECO:0000256|RuleBase:RU371123};
GN ORFNames=CELE_F47B7.2 {ECO:0000313|EMBL:CCD70493.1}, F47B7.2
GN {ECO:0000313|EMBL:CCD70493.1, ECO:0000313|WormBase:F47B7.2c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70493.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70493.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70493.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR';
CC Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2;
CC Evidence={ECO:0000256|RuleBase:RU371123};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU371123};
CC -!- SIMILARITY: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
CC {ECO:0000256|ARBA:ARBA00006041}.
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DR EMBL; BX284606; CCD70493.1; -; Genomic_DNA.
DR RefSeq; NP_508653.1; NM_076252.4.
DR AlphaFoldDB; Q95QF9; -.
DR SMR; Q95QF9; -.
DR EPD; Q95QF9; -.
DR EnsemblMetazoa; F47B7.2c.1; F47B7.2c.1; WBGene00018533.
DR GeneID; 180664; -.
DR UCSC; F47B7.2c; c. elegans.
DR AGR; WB:WBGene00018533; -.
DR WormBase; F47B7.2c; CE28395; WBGene00018533; -.
DR HOGENOM; CLU_020182_0_0_1; -.
DR OrthoDB; 20090at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00018533; Expressed in embryo and 4 other cell types or tissues.
DR ExpressionAtlas; Q95QF9; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016971; F:flavin-dependent sulfhydryl oxidase activity; IBA:GO_Central.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR CDD; cd02992; PDI_a_QSOX; 1.
DR Gene3D; 1.20.120.310; ERV/ALR sulfhydryl oxidase domain; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.20.120.1960; QSOX sulfhydryl oxidase domain; 1.
DR InterPro; IPR036774; ERV/ALR_sulphydryl_oxid_sf.
DR InterPro; IPR017905; ERV/ALR_sulphydryl_oxidase.
DR InterPro; IPR040986; QSOX_FAD-bd_dom.
DR InterPro; IPR042568; QSOX_FAD-bd_sf.
DR InterPro; IPR039798; Sulfhydryl_oxidase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR22897; QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE; 1.
DR PANTHER; PTHR22897:SF8; SULFHYDRYL OXIDASE; 1.
DR Pfam; PF04777; Evr1_Alr; 1.
DR Pfam; PF18371; FAD_SOX; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF69000; FAD-dependent thiol oxidase; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51324; ERV_ALR; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU371123};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU371123}; Membrane {ECO:0000256|RuleBase:RU371123};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU371123};
KW Proteomics identification {ECO:0007829|EPD:Q95QF9,
KW ECO:0007829|PeptideAtlas:Q95QF9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|RuleBase:RU371123};
KW Transmembrane helix {ECO:0000256|RuleBase:RU371123}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU371123"
FT DOMAIN 24..164
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 410..517
FT /note="ERV/ALR sulfhydryl oxidase"
FT /evidence="ECO:0000259|PROSITE:PS51324"
SQ SEQUENCE 624 AA; 70048 MW; A72E1B3AC5A92E90 CRC64;
MNEKEPGVAK SLCIAAVITG VFMLFILVVI LAFSAGGSSG ESLYDKDDPI LELDVDTFSA
AIYGSKKAHF IEFYSSWCGA CIGYAPTFKK FAKQLEKWAP LVQVTVVNCA DDKNMPLCRE
HSVSSYPSLR YFKYNSHNKD DGMKYSGDKY DINKLAHDIA GLAQADAQKQ NPESWPTFLP
LSDTTTLEEV FKSIGTTSYL AIVVQDSPSV IAWANLINYH GNNGVKVAYV TQNHPIATKF
FSDGGVHALL FSNGNQEPLW KSSSPVDKWV DVQDKIDELI GDKIAASGPT VHPINAAPVI
AAPSNPLNNQ YEVQLVDLKS AMSYMLYKEI PRREEIRDEP MAVLKQWMHT LKKYAPGTTP
MRRLFFRLDE WIQLQSVVTA NEWITKVDEI QQALGNPLPK EITWMACAGS KPNLRGYTCG
LWTLAHTITV EAYKQEKHNT AFKPVIDVLE PFRAFIFHFL SCSECAQNFT KEAEKNQLHL
VTRPEDVYAW LWRVHNFVNK RLSGSLTDDP SFKKQQFPPK SLCADCYDAN GDIDEAKALP
FVFKYYSNIK TDSTDNLPGY KVVEYKEGKT LSAGQRHLNP KFQVHAGKVD QLEANDKVKN
VLDASPQRTW KDIDGYGVLG VPHR
//
