ID Q95Y05_CAEEL Unreviewed; 417 AA.
AC Q95Y05;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 3.
DT 27-MAR-2024, entry version 173.
DE SubName: Full=NR LBD domain-containing protein {ECO:0000313|EMBL:CCD66721.2};
GN Name=nhr-274 {ECO:0000313|EMBL:CCD66721.2,
GN ECO:0000313|WormBase:Y41D4B.21a};
GN ORFNames=CELE_Y41D4B.21 {ECO:0000313|EMBL:CCD66721.2}, Y41D4B.21
GN {ECO:0000313|WormBase:Y41D4B.21a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD66721.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD66721.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD66721.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284604; CCD66721.2; -; Genomic_DNA.
DR RefSeq; NP_500114.3; NM_067713.3.
DR AlphaFoldDB; Q95Y05; -.
DR SMR; Q95Y05; -.
DR IntAct; Q95Y05; 1.
DR STRING; 6239.Y41D4B.21a.1; -.
DR PaxDb; 6239-Y41D4B-21a; -.
DR PeptideAtlas; Q95Y05; -.
DR EnsemblMetazoa; Y41D4B.21a.1; Y41D4B.21a.1; WBGene00021522.
DR GeneID; 189825; -.
DR UCSC; Y41D4B.21; c. elegans.
DR AGR; WB:WBGene00021522; -.
DR WormBase; Y41D4B.21a; CE47672; WBGene00021522; nhr-274.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_0_0_1; -.
DR InParanoid; Q95Y05; -.
DR OMA; TNESRCI; -.
DR OrthoDB; 2876785at2759; -.
DR PhylomeDB; Q95Y05; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00021522; Expressed in adult organism and 3 other cell types or tissues.
DR ExpressionAtlas; Q95Y05; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR46587:SF3; NR LBD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46587; NUCLEAR HORMONE RECEPTOR FAMILY; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 33..108
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 139..417
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 417 AA; 47196 MW; 0995F13C5B538600 CRC64;
MSSGEVMTYG EIHRISTSSP DTSPPGTSTQ DDTDGCAVCG DRVNGKRYGA PACLGCIVFF
RRAVTNEVTY KCLKGGTCVI TNESRCICRY CRLQKCYTVG MKASAIQRRD VMGPRKPKIK
ESIVKTEIIE EVPKLIMSSN PSSTGSMSEG PPKHKRPLLE DLVEVQRWQC SKHHSFFEAH
EAINLDGDLY AHMHLKLNGT LHRRARARDV NSMLKLGLID AATWGNQFDL FRRLSTEEKK
HILTEFGFTF MLVDQGYKTA QKAEKGFWLL QNDTYMHEDY FLGLPEEDAR KENAATKAKL
HPLFVNESLN CVGYPFKNLQ IDEHECAVLK TILLLTQQGV FKHCVNEVKH LYDCCMTELM
GHSQRKYPDT AAERFGTIIL LTSSIRCAIN ALYNQTRVSD VFDLMKFDPL VRDVLLS
//
