ID   Q966P1_CAEEL            Unreviewed;       943 AA.
AC   Q966P1;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 146.
DE   SubName: Full=Hormone-sensitive lipase {ECO:0000313|EMBL:CCD67457.1};
GN   Name=hosl-1 {ECO:0000313|EMBL:CCD67457.1,
GN   ECO:0000313|WormBase:C46C11.1a};
GN   ORFNames=C46C11.1 {ECO:0000313|WormBase:C46C11.1a}, CELE_C46C11.1
GN   {ECO:0000313|EMBL:CCD67457.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD67457.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD67457.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD67457.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284606; CCD67457.1; -; Genomic_DNA.
DR   RefSeq; NP_001041228.1; NM_001047763.3.
DR   AlphaFoldDB; Q966P1; -.
DR   SMR; Q966P1; -.
DR   STRING; 6239.C46C11.1a.1; -.
DR   ESTHER; caeel-C46C11.1; Hormone-sensitive_lipase_like.
DR   EPD; Q966P1; -.
DR   PaxDb; 6239-C46C11-1a; -.
DR   EnsemblMetazoa; C46C11.1a.1; C46C11.1a.1; WBGene00016704.
DR   GeneID; 180737; -.
DR   KEGG; cel:CELE_C46C11.1; -.
DR   AGR; WB:WBGene00016704; -.
DR   WormBase; C46C11.1a; CE27859; WBGene00016704; hosl-1.
DR   eggNOG; KOG4388; Eukaryota.
DR   GeneTree; ENSGT00730000111056; -.
DR   InParanoid; Q966P1; -.
DR   OMA; CKETQFA; -.
DR   OrthoDB; 2941058at2759; -.
DR   PhylomeDB; Q966P1; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00016704; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR   ExpressionAtlas; Q966P1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004771; F:sterol esterase activity; IBA:GO_Central.
DR   GO; GO:0004806; F:triglyceride lipase activity; IBA:GO_Central.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR   GO; GO:0019433; P:triglyceride catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   InterPro; IPR010468; HSL_N.
DR   PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF07859; Abhydrolase_3; 2.
DR   Pfam; PF06350; HSL_N; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Proteomics identification {ECO:0007829|EPD:Q966P1,
KW   ECO:0007829|PeptideAtlas:Q966P1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT   DOMAIN          62..364
FT                   /note="Hormone-sensitive lipase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06350"
FT   DOMAIN          380..522
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   DOMAIN          832..912
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          710..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          599..626
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        732..783
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   943 AA;  105667 MW;  AE0B393146FDD1BD CRC64;
     MPKRKFRTVC RRVINRFVII KKLKGNFRTT GVAQKMADSG GSNKRRQKLN GRLSVDRCAI
     LELIVQMCSD NATHFEKLAQ SGANGYNERM PVVQTALQTA IETLKGNIKK LQEVAPKYDY
     DEKTPGNGYR SLICICDTTL LHVVSLQKAV FEQRGYLIFR ISHFCKELEA YATVIDYLNK
     FIPLCLETER NMRGSLFPPL DGNYETYQEI LRVMEKLDSS VFFGRPIGFQ FSPSINKIFR
     IIGVVLATYS LSWEKGHGAI GSLINTGRFF LSPEQRAERI IKVTKEADID FCKGFWNLSE
     LSNNMPKFFC PNMALNELRE IPLDGAIPME GKSGEMVMVP EPSAHTGPRP VQYRILSTVH
     REKMSSSALS TTHPPSKYLV LHCHGGGYVA TSSKSHETYL RQWSKALNCP VVSVEYSLAP
     ENPFPRPTEE VLFAYSWIIN NPAAVGWTGE KIVMVGDSAG GNLIMSVNLR LIQLNIKRQP
     DGLVLCYTPF LFQYLPSPSR MLSVMDPLLH TGVVLRIVAA YTGAYGAQMN NNKLKKSKNC
     LGDNDMYASH RSLQEYVNEV QKTKVDFSGG SQSIVSLVQK SHDNDGFSKT KGNSYYKKES
     KEKVDVDRVE NEIEEKTDKN DVDSEDDALE TTSIGSVQVD ADPFHIQLNQ TLHDDDLISF
     LSHHPLTKYA MSHTPDMGED DIELIDTPVE LGLEATENLV IEEEIEALTS VDEVSTPSTE
     NIQEVHTTKR PRLLQMLSSV TSRESRDTQT APSTPLQQPK PLSHSSSMNG FNPPVHKRSL
     SQSLADTAAS TAAYALDNLQ DWFERAPKEK QKLDRTISRK DEGDFLEEVI EEDERPSHLI
     ELVSANTVPR DPLISPMYAD NETMCQLPPC YFMACHMDPL LDDTISFAGK LRDAGGKVMS
     VDLLSSVPHG FLNFTLISPE CKKSGQVCIN RLKEALGINE EPR
//