ID ZN524_HUMAN Reviewed; 264 AA.
AC Q96C55; Q6NW31; Q96IL7;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 175.
DE RecName: Full=Zinc finger protein 524;
GN Name=ZNF524;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Colon, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96C55; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-10283126, EBI-3866279;
CC Q96C55; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10283126, EBI-618309;
CC Q96C55; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10283126, EBI-5916454;
CC Q96C55; P28799: GRN; NbExp=3; IntAct=EBI-10283126, EBI-747754;
CC Q96C55; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10283126, EBI-10975473;
CC Q96C55; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10283126, EBI-11959885;
CC Q96C55; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10283126, EBI-10172290;
CC Q96C55; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10283126, EBI-10171774;
CC Q96C55; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10283126, EBI-10172052;
CC Q96C55; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10283126, EBI-14065470;
CC Q96C55; Q99750: MDFI; NbExp=3; IntAct=EBI-10283126, EBI-724076;
CC Q96C55; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-10283126, EBI-79165;
CC Q96C55; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10283126, EBI-396669;
CC Q96C55; Q14140: SERTAD2; NbExp=3; IntAct=EBI-10283126, EBI-2822051;
CC Q96C55; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10283126, EBI-5235340;
CC Q96C55; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10283126, EBI-11741437;
CC Q96C55; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-10283126, EBI-947459;
CC Q96C55; O76024: WFS1; NbExp=3; IntAct=EBI-10283126, EBI-720609;
CC Q96C55; Q9NQZ6: ZC4H2; NbExp=3; IntAct=EBI-10283126, EBI-747993;
CC Q96C55; Q96PQ6: ZNF317; NbExp=3; IntAct=EBI-10283126, EBI-1210473;
CC Q96C55; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-10283126, EBI-11035148;
CC Q96C55; Q9NQZ8: ZNF71; NbExp=3; IntAct=EBI-10283126, EBI-7138235;
CC Q96C55; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-10283126, EBI-5667516;
CC Q96C55; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-10283126, EBI-11962574;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC007396; AAH07396.2; -; mRNA.
DR EMBL; BC014666; AAH14666.1; -; mRNA.
DR EMBL; BC067748; AAH67748.1; -; mRNA.
DR CCDS; CCDS12929.1; -.
DR RefSeq; NP_694951.1; NM_153219.3.
DR PDB; 7YSF; X-ray; 2.40 A; A=107-237.
DR PDBsum; 7YSF; -.
DR AlphaFoldDB; Q96C55; -.
DR SMR; Q96C55; -.
DR BioGRID; 127090; 63.
DR IntAct; Q96C55; 31.
DR STRING; 9606.ENSP00000466907; -.
DR iPTMnet; Q96C55; -.
DR PhosphoSitePlus; Q96C55; -.
DR BioMuta; ZNF524; -.
DR DMDM; 74760750; -.
DR EPD; Q96C55; -.
DR jPOST; Q96C55; -.
DR MassIVE; Q96C55; -.
DR MaxQB; Q96C55; -.
DR PaxDb; 9606-ENSP00000466907; -.
DR PeptideAtlas; Q96C55; -.
DR ProteomicsDB; 76160; -.
DR Pumba; Q96C55; -.
DR Antibodypedia; 33130; 76 antibodies from 15 providers.
DR DNASU; 147807; -.
DR Ensembl; ENST00000301073.4; ENSP00000301073.2; ENSG00000171443.7.
DR Ensembl; ENST00000591046.1; ENSP00000466907.1; ENSG00000171443.7.
DR GeneID; 147807; -.
DR KEGG; hsa:147807; -.
DR MANE-Select; ENST00000301073.4; ENSP00000301073.2; NM_153219.4; NP_694951.1.
DR UCSC; uc002qlk.2; human.
DR AGR; HGNC:28322; -.
DR CTD; 147807; -.
DR GeneCards; ZNF524; -.
DR HGNC; HGNC:28322; ZNF524.
DR HPA; ENSG00000171443; Low tissue specificity.
DR neXtProt; NX_Q96C55; -.
DR PharmGKB; PA134981576; -.
DR VEuPathDB; HostDB:ENSG00000171443; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163198; -.
DR HOGENOM; CLU_1057530_0_0_1; -.
DR InParanoid; Q96C55; -.
DR OMA; ETPWDEE; -.
DR OrthoDB; 3378355at2759; -.
DR PhylomeDB; Q96C55; -.
DR TreeFam; TF338348; -.
DR PathwayCommons; Q96C55; -.
DR SignaLink; Q96C55; -.
DR BioGRID-ORCS; 147807; 19 hits in 1177 CRISPR screens.
DR GenomeRNAi; 147807; -.
DR Pharos; Q96C55; Tdark.
DR PRO; PR:Q96C55; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96C55; Protein.
DR Bgee; ENSG00000171443; Expressed in body of pancreas and 97 other cell types or tissues.
DR ExpressionAtlas; Q96C55; baseline and differential.
DR Genevisible; Q96C55; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF120; KRUEPPEL-LIKE FACTOR 15; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..264
FT /note="Zinc finger protein 524"
FT /id="PRO_0000234579"
FT DNA_BIND 51..63
FT /note="A.T hook"
FT ZN_FING 114..136
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 142..164
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 170..192
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 198..221
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..264
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 51
FT /note="P -> H (in Ref. 1; AAH67748)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="P -> T (in Ref. 1; AAH67748)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 28709 MW; B248388F26BBB487 CRC64;
MDTPSPDPLP SPLPGEEEKP LALSPPVPRG RRGRRPGGAT SSNRTLKASL PRKRGRPPKS
GQEPPLVQVQ GVTAPVGSSG GSDLLLIDDQ GVPYTVSEGS AAGPEGSGPR KAPHFCPVCL
RAFPYLSDLE RHSISHSELK PHQCKVCGKT FKRSSHLRRH CNIHAGLRPF RCPLCPRRFR
EAGELAHHHR VHSGERPYQC PICRLRFTEA NTLRRHAKRK HPEAMGVPLC APDPGSEPPW
DEEGIPATAG AEEEEETEGK GEPA
//
