ID Q96QC4_HUMAN Unreviewed; 332 AA.
AC Q96QC4;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 192.
DE SubName: Full=MHC class I chain-related protein A {ECO:0000313|EMBL:QEZ90734.1};
DE SubName: Full=MHC class I polypeptide-related sequence A {ECO:0000313|EMBL:EAX03396.1, ECO:0000313|EMBL:QOY57152.1, ECO:0000313|Ensembl:ENSP00000394553.1};
DE SubName: Full=MICA {ECO:0000313|EMBL:ARB08519.1, ECO:0000313|EMBL:BAG61187.1};
DE SubName: Full=Stress inducible class I homolog {ECO:0000313|EMBL:BAB63308.1};
GN Name=MICA {ECO:0000313|EMBL:BAB63308.1,
GN ECO:0000313|Ensembl:ENSP00000394553.1};
GN ORFNames=hCG_2001511 {ECO:0000313|EMBL:EAX03396.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAB63308.1};
RN [1] {ECO:0000313|EMBL:EAX03396.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11181995; DOI=10.1126/science.1058040;
RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P.,
RA Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.,
RA Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J.,
RA Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J.,
RA McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C.,
RA Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M.,
RA Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C.,
RA Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K.,
RA Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P.,
RA Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y.,
RA Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N.,
RA Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B.,
RA Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J.,
RA Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W.,
RA Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S.,
RA Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T.,
RA Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I.,
RA Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L.,
RA Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L.,
RA Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C.,
RA Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C.,
RA Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D.,
RA McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B.,
RA Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S.,
RA Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S.,
RA Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R.,
RA Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B.,
RA Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S.,
RA Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S.,
RA Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J.,
RA Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M.,
RA Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S.,
RA Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M.,
RA Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J.,
RA Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J.,
RA Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N.,
RA Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT "The sequence of the human genome.";
RL Science 291:1304-1351(2001).
RN [2] {ECO:0000313|EMBL:BAB63308.1}
RP NUCLEOTIDE SEQUENCE.
RA Hirakawa M., Yamaguchi H., Imai K., Shimada J.;
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSP00000394553.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4] {ECO:0000313|EMBL:BAB63308.1}
RP NUCLEOTIDE SEQUENCE.
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:EAX03396.1}
RP NUCLEOTIDE SEQUENCE.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:BAG61187.1}
RP NUCLEOTIDE SEQUENCE.
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:ARB08519.1}
RP NUCLEOTIDE SEQUENCE.
RA Norman P.J., Norberg S.J., Guethlein L.A., Nemat-Gorgani N., Ronaghi M.,
RA Parham P.;
RT "MIC gene sequence alleles derived from homozygous individuals.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:QEZ90734.1}
RP NUCLEOTIDE SEQUENCE.
RA Zou Y., Monos D., Luo Q., Ferriola D.;
RT "Complete single MICA gene sequencing-based typing using next generation
RT sequencer of Miseq and Nanopore.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0007829|PDB:6DDM, ECO:0007829|PDB:6DDR}
RP X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 204-297, AND DISULFIDE BONDS.
RX PubMed=30307368; DOI=10.1080/19420862.2018.1532767;
RA Lombana T.N., Matsumoto M.L., Berkley A.M., Toy E., Cook R., Gan Y., Du C.,
RA Schnier P., Sandoval W., Ye Z., Schartner J.M., Kim J., Spiess C.;
RT "High-resolution glycosylation site-engineering method identifies MICA
RT epitope critical for shedding inhibition activity of anti-MICA
RT antibodies.";
RL MAbs 11:75-93(2019).
RN [10] {ECO:0000313|EMBL:QOY57152.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=15-9488 {ECO:0000313|EMBL:QOY57152.1}, 17-4303
RC {ECO:0000313|EMBL:QOY57173.1}, 17-4306 {ECO:0000313|EMBL:QOY57175.1},
RC 17-4310 {ECO:0000313|EMBL:QOY57176.1}, 17-6716
RC {ECO:0000313|EMBL:QOY57177.1}, and 17-6717
RC {ECO:0000313|EMBL:QOY57178.1};
RA Zou Y., Duke J.L., Ferriola D., Luo Q., Wasserman J., Luo W., Huang Y.,
RA Cai L., Tairis N., Damianos G., Pagkrati I., Mosbruger T.L., Monos D.;
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|Ensembl:ENSP00000394553.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; AL645933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL669854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX005439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX119958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KY500931; ARB08519.1; -; Genomic_DNA.
DR EMBL; KY500934; ARB08522.1; -; Genomic_DNA.
DR EMBL; KY500935; ARB08523.1; -; Genomic_DNA.
DR EMBL; KY500937; ARB08525.1; -; Genomic_DNA.
DR EMBL; KY500938; ARB08526.1; -; Genomic_DNA.
DR EMBL; KY500939; ARB08527.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63308.1; -; Genomic_DNA.
DR EMBL; AK299135; BAG61187.1; -; mRNA.
DR EMBL; CH471081; EAX03396.1; -; Genomic_DNA.
DR EMBL; MH708875; QEZ90734.1; -; Genomic_DNA.
DR EMBL; MN894327; QOY57152.1; -; Genomic_DNA.
DR EMBL; MN894348; QOY57173.1; -; Genomic_DNA.
DR EMBL; MN894349; QOY57174.1; -; Genomic_DNA.
DR EMBL; MN894350; QOY57175.1; -; Genomic_DNA.
DR EMBL; MN894351; QOY57176.1; -; Genomic_DNA.
DR EMBL; MN894352; QOY57177.1; -; Genomic_DNA.
DR EMBL; MN894353; QOY57178.1; -; Genomic_DNA.
DR RefSeq; NP_001170990.1; NM_001177519.2.
DR RefSeq; NP_001276081.1; NM_001289152.1.
DR RefSeq; NP_001276082.1; NM_001289153.1.
DR RefSeq; NP_001276083.1; NM_001289154.1.
DR PDB; 6DDM; X-ray; 1.30 A; C=204-297.
DR PDB; 6DDR; X-ray; 1.90 A; C=204-297.
DR PDB; 6DDV; X-ray; 2.05 A; C=204-297.
DR PDBsum; 6DDM; -.
DR PDBsum; 6DDR; -.
DR PDBsum; 6DDV; -.
DR IntAct; Q96QC4; 2.
DR ProteomicsDB; 77852; -.
DR Antibodypedia; 45198; 525 antibodies from 23 providers.
DR DNASU; 100507436; -.
DR Ensembl; ENST00000415525.5; ENSP00000416941.1; ENSG00000231225.9.
DR Ensembl; ENST00000427477.5; ENSP00000394553.1; ENSG00000233051.9.
DR Ensembl; ENST00000449934.7; ENSP00000413079.1; ENSG00000204520.14.
DR Ensembl; ENST00000546529.3; ENSP00000446655.1; ENSG00000231225.9.
DR Ensembl; ENST00000547767.2; ENSP00000447026.1; ENSG00000233051.9.
DR GeneID; 100507436; -.
DR MANE-Select; ENST00000449934.7; ENSP00000413079.1; NM_001177519.3; NP_001170990.1.
DR UCSC; uc003ntk.3; human.
DR CTD; 100507436; -.
DR HGNC; HGNC:7090; MICA.
DR PharmGKB; PA30811; -.
DR VEuPathDB; HostDB:ENSG00000204520; -.
DR GeneTree; ENSGT01100000263517; -.
DR HOGENOM; CLU_047501_4_0_1; -.
DR OMA; EPCHREI; -.
DR OrthoDB; 3840485at2759; -.
DR TreeFam; TF342166; -.
DR BioGRID-ORCS; 100507436; 4 hits in 1115 CRISPR screens.
DR ChiTaRS; MICA; human.
DR GenomeRNAi; 100507436; -.
DR Proteomes; UP000005640; Unplaced.
DR Bgee; ENSG00000204520; Expressed in descending thoracic aorta and 96 other cell types or tissues.
DR CDD; cd21017; IgC1_MHC_Ia_MIC-A_MIC-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR PANTHER; PTHR16675:SF154; MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A-RELATED; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6DDM, ECO:0007829|PDB:6DDR};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Metal-binding {ECO:0007829|PDB:6DDR};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q96QC4,
KW ECO:0007829|ProteomicsDB:Q96QC4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0007829|PDB:6DDR}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..332
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014589245"
FT DOMAIN 207..296
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT BINDING 248
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:6DDR"
FT BINDING 249
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0007829|PDB:6DDR"
FT DISULFID 225..282
FT /evidence="ECO:0007829|PDB:6DDM, ECO:0007829|PDB:6DDR"
SQ SEQUENCE 332 AA; 37834 MW; A8D8C5080781CB90 CRC64;
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLAEVH LDGQPFLRYD
RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE
IHEDNSTRSS QHFYYDGELF LSQNLETEEW TVPQSSRAQT LAMNVRNFLK EDAMKTKTHY
HAMHADCLQE LRRYLESGVV LRRTVPPMVN VTRSEASEGN ITVTCRASSF YPRNIILTWR
QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICRGEEQRF TCYMEHSGNH STHPVPSGKV
LVLQSHWQTF HVSAVAAGCC YFCYYYFLCP LL
//
