ID OR2A5_HUMAN Reviewed; 311 AA.
AC Q96R48; B9EGX2; O43885; O43888;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 24-JAN-2024, entry version 164.
DE RecName: Full=Olfactory receptor 2A5;
DE AltName: Full=Olfactory receptor 2A26;
DE AltName: Full=Olfactory receptor 2A8;
DE AltName: Full=Olfactory receptor 7-138/7-141;
DE Short=OR7-138;
DE Short=OR7-141;
GN Name=OR2A5; Synonyms=OR2A26, OR2A8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
RX PubMed=9500546; DOI=10.1038/ng0398-243;
RA Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA Demaille J.G., Giorgi D.;
RT "Distribution of olfactory receptor genes in the human genome.";
RL Nat. Genet. 18:243-250(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2A5";
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DR EMBL; AC091768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136860; AAI36861.1; -; mRNA.
DR EMBL; U86278; AAC39630.1; -; Genomic_DNA.
DR EMBL; U86281; AAC39633.1; -; Genomic_DNA.
DR EMBL; AF399595; AAK95080.1; -; Genomic_DNA.
DR CCDS; CCDS43668.1; -.
DR RefSeq; NP_036497.1; NM_012365.1.
DR AlphaFoldDB; Q96R48; -.
DR SMR; Q96R48; -.
DR STRING; 9606.ENSP00000493295; -.
DR GlyCosmos; Q96R48; 1 site, No reported glycans.
DR GlyGen; Q96R48; 1 site.
DR iPTMnet; Q96R48; -.
DR PhosphoSitePlus; Q96R48; -.
DR BioMuta; OR2A5; -.
DR DMDM; 85692724; -.
DR MassIVE; Q96R48; -.
DR PaxDb; 9606-ENSP00000386208; -.
DR PeptideAtlas; Q96R48; -.
DR Antibodypedia; 32700; 84 antibodies from 19 providers.
DR DNASU; 393046; -.
DR Ensembl; ENST00000641693.1; ENSP00000493295.1; ENSG00000221836.4.
DR Ensembl; ENST00000644547.1; ENSP00000494865.1; ENSG00000284896.1.
DR Ensembl; ENST00000645588.1; ENSP00000496685.1; ENSG00000284896.1.
DR GeneID; 393046; -.
DR KEGG; hsa:393046; -.
DR MANE-Select; ENST00000641693.1; ENSP00000493295.1; NM_012365.2; NP_036497.1.
DR UCSC; uc011ktw.3; human.
DR AGR; HGNC:8232; -.
DR CTD; 393046; -.
DR DisGeNET; 393046; -.
DR GeneCards; OR2A5; -.
DR HGNC; HGNC:8232; OR2A5.
DR HPA; ENSG00000221836; Not detected.
DR neXtProt; NX_Q96R48; -.
DR OpenTargets; ENSG00000221836; -.
DR PharmGKB; PA32118; -.
DR VEuPathDB; HostDB:ENSG00000221836; -.
DR eggNOG; ENOG502SIA2; Eukaryota.
DR GeneTree; ENSGT00940000153255; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q96R48; -.
DR OMA; VLWKERS; -.
DR OrthoDB; 5259681at2759; -.
DR PhylomeDB; Q96R48; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q96R48; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 393046; 12 hits in 731 CRISPR screens.
DR GeneWiki; OR2A5; -.
DR GenomeRNAi; 393046; -.
DR Pharos; Q96R48; Tdark.
DR PRO; PR:Q96R48; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96R48; Protein.
DR Bgee; ENSG00000221836; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 80 other cell types or tissues.
DR ExpressionAtlas; Q96R48; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR CDD; cd15420; 7tmA_OR2A-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF232; OLFACTORY RECEPTOR 2A5; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 2A5"
FT /id="PRO_0000150455"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 126
FT /note="I -> V (in dbSNP:rs2961144)"
FT /id="VAR_053129"
FT VARIANT 202
FT /note="A -> S (in dbSNP:rs6464573)"
FT /id="VAR_053130"
FT VARIANT 255
FT /note="A -> T (in dbSNP:rs6464574)"
FT /id="VAR_059984"
FT CONFLICT 76
FT /note="N -> K (in Ref. 3; AAC39633 and 4; AAK95080)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="R -> G (in Ref. 3; AAC39630 and 4; AAK95080)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 35207 MW; 0E515A53AEF1A950 CRC64;
MTKNQTWVTE FILLGFPLSL RIQMLLSGLF SLLYVFTLLG NGAILGLIWL DSRLHTPMYF
FLSHLAIIDI SYASNNVPKM LTNLGLNKRK TISFVPCTMQ TFLYMAFAHT ECLILVMMSY
DRYMAICHPL QYSVIMRWGV CTVLAVTSWA CGSLLALVHV VLILRLPFCG PHEINHFFCE
ILSVLKLACA DTWLNQVVIF AASVFILVGP LCLVLVSYSR ILAAILRIQS GEGRRKAFST
CSSHLCMVGL FFGSAIVMYM APKSRHPEEQ QKVLSLFYSL FNPMLNPLIY SLRNAEVKGA
LKRVLWKQRS K
//
