ID Q975S3_SULTO Unreviewed; 654 AA.
AC Q975S3;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Formate dehydrogenase {ECO:0000313|EMBL:BAB65327.1};
DE EC=1.2.1.2 {ECO:0000313|EMBL:BAB65327.1};
GN Name=ST0348 {ECO:0000313|EMBL:BAB65327.1};
GN OrderedLocusNames=STK_03480 {ECO:0000313|EMBL:BAB65327.1};
OS Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
OS (Sulfolobus tokodaii).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfurisphaera.
OX NCBI_TaxID=273063 {ECO:0000313|EMBL:BAB65327.1, ECO:0000313|Proteomes:UP000001015};
RN [1] {ECO:0000313|Proteomes:UP000001015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16993 / JCM 10545 / NBRC 100140 / 7
RC {ECO:0000313|Proteomes:UP000001015};
RX PubMed=11572479; DOI=10.1093/dnares/8.4.123;
RA Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M.,
RA Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y.,
RA Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T.,
RA Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K.,
RA Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H.;
RT "Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon,
RT Sulfolobus tokodaii strain7.";
RL DNA Res. 8:123-140(2001).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000023; BAB65327.1; -; Genomic_DNA.
DR RefSeq; WP_010978310.1; NC_003106.2.
DR AlphaFoldDB; Q975S3; -.
DR STRING; 273063.STK_03480; -.
DR GeneID; 1458270; -.
DR KEGG; sto:STK_03480; -.
DR PATRIC; fig|273063.9.peg.406; -.
DR eggNOG; arCOG01491; Archaea.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000001015; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:BAB65327.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001015}.
FT DOMAIN 1..57
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 654 AA; 73421 MW; 0249E3219613C216 CRC64;
METVKSICPF CGVGCGVELY VESSTIIRLS PVKEHVVSRG HLCGKGTLAY EPIFAWDRLT
YPLKKVKGEH IRISWEIAIK EIASKLKEII QQYGSDAIAF YGGCQNTLEE DYLMQKLARA
MGTNNIDSCA RVCHDPSATA LKEMVGIGAS SVSVEMIPRM KVVVITGESI TESHPVLSQY
LTEAKKNGTK LIVIDPRVTG TAKFSDLHLR LRPGTDIALF NAVGNYLIEN SLIDEKFIKE
RVIGFEEYAK GVSKYTLEYA EKVTGVRKEN IKKFAELIAQ KGVIFSWGLG LTQSSGVNGV
RAYINLALLT GNIGKNGGLL VFRGQTNVQG SGDLLKPDKF PNGTMDEENA KKLAEIWNFL
PPTKPGLSVT EALLRDNNIR AIIFMGFNPL ISLPNREKVE RKLKSLDLLV VIDAFMTETA
SLAHYVLPAA VWAEKEGSVT NLDRLAKWRF KAIDPPGEAK PDYEILKKLA EELGYNFSSD
PKEIFEEMKK VVPLYSNLTL DEIMDYSSSS RYPNHEIYLY DEKFYTETNK AKLILVEQPE
VKNGIILITV RNVTRYNTDV ITGRIPGYGK YESLIYVSQE DALELKIRDN EEVLVTSECG
KMNFRVMISK DVQKGTAIMY MHDPKVNYII CDELDEITKT PKYKYTEIKI MKLN
//
