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Database: UniProt
Entry: Q976E8_SULTO
LinkDB: Q976E8_SULTO
Original site: Q976E8_SULTO 
ID   Q976E8_SULTO            Unreviewed;       222 AA.
AC   Q976E8;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 2.
DT   24-JAN-2024, entry version 93.
DE   RecName: Full=3-hexulose-6-phosphate synthase {ECO:0000256|ARBA:ARBA00012890};
DE            EC=4.1.2.43 {ECO:0000256|ARBA:ARBA00012890};
GN   Name=hxlA {ECO:0000313|EMBL:BAB65199.2};
GN   Synonyms=ST0238 {ECO:0000313|EMBL:BAB65199.2};
GN   OrderedLocusNames=STK_02380 {ECO:0000313|EMBL:BAB65199.2};
OS   Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
OS   (Sulfolobus tokodaii).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfurisphaera.
OX   NCBI_TaxID=273063 {ECO:0000313|EMBL:BAB65199.2, ECO:0000313|Proteomes:UP000001015};
RN   [1] {ECO:0000313|Proteomes:UP000001015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16993 / JCM 10545 / NBRC 100140 / 7
RC   {ECO:0000313|Proteomes:UP000001015};
RX   PubMed=11572479; DOI=10.1093/dnares/8.4.123;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M.,
RA   Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y.,
RA   Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T.,
RA   Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K.,
RA   Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H.;
RT   "Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon,
RT   Sulfolobus tokodaii strain7.";
RL   DNA Res. 8:123-140(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC         6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC         ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC         Evidence={ECO:0000256|ARBA:ARBA00000718};
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC       pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC       formaldehyde: step 1/2. {ECO:0000256|ARBA:ARBA00005014}.
CC   -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC       {ECO:0000256|ARBA:ARBA00006350}.
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DR   EMBL; BA000023; BAB65199.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q976E8; -.
DR   STRING; 273063.STK_02380; -.
DR   KEGG; sto:STK_02380; -.
DR   PATRIC; fig|273063.9.peg.284; -.
DR   eggNOG; arCOG00053; Archaea.
DR   OMA; WEQAQEW; -.
DR   UniPathway; UPA00294; UER00434.
DR   Proteomes; UP000001015; Chromosome.
DR   GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04726; KGPDC_HPS; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR041710; HPS/KGPDC.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   NCBIfam; TIGR03128; RuMP_HxlA; 1.
DR   PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR   PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:BAB65199.2};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001015}.
FT   DOMAIN          12..216
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /evidence="ECO:0000259|SMART:SM00934"
SQ   SEQUENCE   222 AA;  24037 MW;  D2A8AC33EA6877A4 CRC64;
     MELLEKLLKS KNLQVALDFI DLKNAEEIAK QSIEAGADIL EVGTPLIKSY GIQGIRRIRE
     IAKERIVLAD TKTADAGDVE AEIVHLGGGN IMTVLGIMDD ATIESAVKKA HEYGILVQAD
     LINVKDILKR AEEIKRLGVD IIGLHVGLDV QKKRGITISD LKNEIKKVSE LGVIVSVAGG
     LNKNNIVDII DLPINIYVVG GAITRAKNPL EEAKQIVKII KG
//
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