ID Q97KM4_CLOAB Unreviewed; 286 AA.
AC Q97KM4;
DT 01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:AAK78869.1};
GN OrderedLocusNames=CA_C0893 {ECO:0000313|EMBL:AAK78869.1};
OS Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS / VKM B-1787).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=272562 {ECO:0000313|EMBL:AAK78869.1, ECO:0000313|Proteomes:UP000000814};
RN [1] {ECO:0000313|EMBL:AAK78869.1, ECO:0000313|Proteomes:UP000000814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC {ECO:0000313|Proteomes:UP000000814};
RX PubMed=11466286; DOI=10.1128/JB.183.16.4823-4838.2001;
RA Nolling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA Doucette-Stamm L., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
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DR EMBL; AE001437; AAK78869.1; -; Genomic_DNA.
DR PIR; B97010; B97010.
DR RefSeq; NP_347529.1; NC_003030.1.
DR RefSeq; WP_010964211.1; NC_003030.1.
DR AlphaFoldDB; Q97KM4; -.
DR STRING; 272562.CA_C0893; -.
DR DNASU; 1117076; -.
DR GeneID; 44997403; -.
DR KEGG; cac:CA_C0893; -.
DR PATRIC; fig|272562.8.peg.1102; -.
DR eggNOG; COG0287; Bacteria.
DR HOGENOM; CLU_055968_2_0_9; -.
DR OrthoDB; 9802008at2; -.
DR Proteomes; UP000000814; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000814}.
FT DOMAIN 8..286
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 286 AA; 31789 MW; AEF9591220EEBB32 CRC64;
MEDGEFNINL TIVGLGLMGG SYAMALKEKN KGHIWGVDLD NNTLKNAAEM DIIDEGYSIE
NAYIPLKKSD IVIIAIYPEA LVQFVKNNVN NFKKGAIITD VLGIKEDNIS YIQSILGDSA
EFLGGHPMAG KEVSGFSNAS KNIFNNANYI LTPTVKNKKD TIEFMKKFIR SIGCTSITEV
TPEKHDEIIA FTSQLPHVIA VSLMNTKSAD DIKHFVGGSF RDATRVAMIN PDLWCQLFMR
NKKNIIDSIE EFQKSLNQIK GFIKEENVND IKQFLKDAAS KKEGTV
//
