ID   Q97TU3_CLOAB            Unreviewed;       857 AA.
AC   Q97TU3;
DT   01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2001, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Transglutaminase-like predicted protease domain fused to ChW-repeats and cell-adhesion domain {ECO:0000313|EMBL:AAK76750.1};
GN   OrderedLocusNames=CA_P0003 {ECO:0000313|EMBL:AAK76750.1};
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OG   Plasmid pSOL1 {ECO:0000313|EMBL:AAK76750.1,
OG   ECO:0000313|Proteomes:UP000000814}.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562 {ECO:0000313|EMBL:AAK76750.1, ECO:0000313|Proteomes:UP000000814};
RN   [1] {ECO:0000313|EMBL:AAK76750.1, ECO:0000313|Proteomes:UP000000814}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC   {ECO:0000313|Proteomes:UP000000814};
RC   PLASMID=pSOL1 {ECO:0000313|Proteomes:UP000000814};
RX   PubMed=11466286; DOI=10.1128/JB.183.16.4823-4838.2001;
RA   Nolling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
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DR   EMBL; AE001438; AAK76750.1; -; Genomic_DNA.
DR   RefSeq; NP_149168.1; NC_001988.2.
DR   AlphaFoldDB; Q97TU3; -.
DR   KEGG; cac:CA_P0003; -.
DR   PATRIC; fig|272562.8.peg.3; -.
DR   HOGENOM; CLU_332265_0_0_9; -.
DR   OrthoDB; 9788327at2; -.
DR   Proteomes; UP000000814; Plasmid pSOL1.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1080; -; 2.
DR   InterPro; IPR003343; Big_2.
DR   InterPro; IPR006637; ChW.
DR   InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR   InterPro; IPR032485; LRP1-like_beta_prop.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   PANTHER; PTHR46333; CYTOKINESIS PROTEIN 3; 1.
DR   PANTHER; PTHR46333:SF2; TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02368; Big_2; 2.
DR   Pfam; PF07538; ChW; 6.
DR   Pfam; PF16472; DUF5050; 1.
DR   Pfam; PF01841; Transglut_core; 1.
DR   SMART; SM00635; BID_2; 2.
DR   SMART; SM00728; ChW; 6.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 2.
DR   SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:AAK76750.1};
KW   Plasmid {ECO:0000313|EMBL:AAK76750.1};
KW   Protease {ECO:0000313|EMBL:AAK76750.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000814}.
FT   DOMAIN          166..243
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          386..463
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          531..586
FT                   /note="Transglutaminase-like"
FT                   /evidence="ECO:0000259|SMART:SM00460"
SQ   SEQUENCE   857 AA;  94686 MW;  7201460135969DC9 CRC64;
     MKKNVLLTIV LIFMLVISYS GGDFKADTNE VGVSYETHVQ NVGWQNWFSD GVEAGTNGQG
     LRIEALKIKL VNAPVGAQIS YSAHVQNVGW QDWVNDGAEA GTDGKGLRVE ALKIKLVNMP
     DYTVQYQAHV QNIGWQNWVS DGAEAGTDGK GYRVEALRIK IVKKVAVQAI TLNKASDELK
     VGQTDQLSAA FNPTDATNKN LSWTSSDASI ASVDSSGKIT ALKQGTSIIT ATTEDGSKTA
     NCSVTVNPGD LQISYTTHVQ NVGWQNWFSD GVEAGTDGQG LRIEALKIKL LNAPAGAQIT
     YRAHVQNVGW QNWVSDGTEA GTDGKGLRVE ALQIKLVNMP DYTVQYQAHV QNVGWQNWVS
     DGAEAGTDGK GYRVEALKIR IVKKIAVQSI TLNKNSDELN VGQTDQLSAV FNPTDATNKN
     IKWTSSDNYV ATVDSTGKIT AVSGGNAVIT ATTEDGSKTA NCSIVVNSTD SKDNQALEKA
     KTVLNTIVQP GMTQVQKELA IHDYIVTNTQ YETAVFTSDN VSDDIYTAYG ALINHRAVCQ
     GYAEAFKMMC NLVGIPTDII EDFKLDHAWN IVKLDDGNYY QVDTTWDDPV YGDDTSLSIS
     HEYFNLSDRQ MFADHTIDKD KWHYPKAAVD NSEFYSISGD SYDSNVVYTN YNGKLSSVDS
     SGNMKTLNDD PSASINYYNG SIYYLSGSSI YKVDTNGQNK VQIASGDIRK MYLYNGAIYY
     LDANDFSINK LVLDGTYKNK KVIGITWNSS YFINNGCLYY EAYDDDYLHK VDLQSLTNTK
     ILTVSDYYVT SYSNYLFYKD SNNLYRTDLN GGNSKLIVNN ITDNFIDIFE NYIYYNDSNN
     IWYKMNLDGS NLIKLMF
//