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Database: UniProt
Entry: Q97VY9
LinkDB: Q97VY9
Original site: Q97VY9 
ID   HELS_SACS2              Reviewed;         708 AA.
AC   Q97VY9;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 1.
DT   16-OCT-2019, entry version 106.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   OrderedLocusNames=SSO2462;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 /
OS   P2) (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G.,
RA   Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A.,
RA   De Moors A., Erauso G., Fletcher C., Gordon P.M.K.,
RA   Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.,
RA   Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N.,
RA   Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK42601.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
DR   EMBL; AE006641; AAK42601.1; ALT_INIT; Genomic_DNA.
DR   PIR; B90418; B90418.
DR   SMR; Q97VY9; -.
DR   STRING; 273057.SSO2462; -.
DR   EnsemblBacteria; AAK42601; AAK42601; SSO2462.
DR   KEGG; sso:SSO2462; -.
DR   PATRIC; fig|273057.12.peg.2540; -.
DR   eggNOG; arCOG00553; Archaea.
DR   eggNOG; COG1204; LUCA.
DR   HOGENOM; HOG000227028; -.
DR   InParanoid; Q97VY9; -.
DR   KO; K03726; -.
DR   OMA; NSNERGD; -.
DR   EvolutionaryTrace; Q97VY9; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    708       ATP-dependent DNA helicase Hel308.
FT                                /FTId=PRO_0000102112.
FT   DOMAIN       33    196       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00442}.
FT   DOMAIN      229    435       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00442}.
FT   NP_BIND      46     53       ATP. {ECO:0000255|HAMAP-Rule:MF_00442}.
FT   MOTIF         1     29       Q motif.
FT   MOTIF       145    148       DEAH box.
FT   BINDING      28     28       ATP. {ECO:0000255|HAMAP-Rule:MF_00442}.
SQ   SEQUENCE   708 AA;  80500 MW;  D52C24C89541C780 CRC64;
     MSIDDLKLPS NVIDIIKNRG IKKLNPPQTE AVKKGLLDGN RLLLTSPTGS GKTLIAEMGI
     ISFLLKNGGK AIYVTPLRAL TNEKYLTFKD WESIGFKVAM TSGDYDTDDA WLKNYDIIIT
     TYEKLDSLWR HRPDWLNEAN YFVLDELHYL NDPERGPVVE SVTIRAKRRN LLALSATISN
     YKQIAKWLGA EPVATNWRPV PLMEGVMYPE RKKKEYTILF RDNTARKVHG DDAIIAYTLD
     SLSKNGQVLV FRNSRKMAES TALKIANYMN FVSLDEKAIS EILKQLDDIE EGGSDEKELL
     KSLISKGVAY HHAGLSKALR DIIEESFRKR KIKVIVATPT LAAGVNLPAR TVIIGDIYRF
     NRKIVGYYDE IPVMEYKQMS GRAGRPGFDQ IGESIIVVRD KEDVDRVFKK YILSDVEPIE
     SKLGSERAFY TFLLGILSAE GSLSEKQLEA FAYESLLAKS VVDVYFDRAI RWLSEHSFIR
     EENNTFTLTN FGKRVADLYI NPFTADIIRK GLEGYKASCE IAYLHLLAFT PDGPLVSVGR
     NEEEELIELL EDLECELLVE EPYEEDEYSL YLNALKVALI MKDWIDEVDE DTILGKYNIG
     SGDLRNIVET MDWLTYSAYH LSKELRLDDH SDKLRILNLR VTDGVKEELL ELVQIGGVGR
     KRARLLYNNG IKGLGDVVMN PDRVRNLLGQ KLGERVVQEA ARLLNRFH
//
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