ID Q981E3_SACS2 Unreviewed; 400 AA.
AC Q981E3;
DT 01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Phosphomethylpyrimidine kinase (ThiD-1) {ECO:0000313|EMBL:AAK40369.1};
DE EC=2.7.4.7 {ECO:0000313|EMBL:AAK40369.1};
GN Name=thiD-1 {ECO:0000313|EMBL:AAK40369.1};
GN OrderedLocusNames=SSO0002 {ECO:0000313|EMBL:AAK40369.1};
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057 {ECO:0000313|EMBL:AAK40369.1, ECO:0000313|Proteomes:UP000001974};
RN [1] {ECO:0000313|Proteomes:UP000001974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2
RC {ECO:0000313|Proteomes:UP000001974};
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
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DR EMBL; AE006641; AAK40369.1; -; Genomic_DNA.
DR PIR; B90139; B90139.
DR RefSeq; WP_009989649.1; NC_002754.1.
DR AlphaFoldDB; Q981E3; -.
DR STRING; 273057.SSO0002; -.
DR PaxDb; 273057-SSO0002; -.
DR EnsemblBacteria; AAK40369; AAK40369; SSO0002.
DR GeneID; 72911804; -.
DR KEGG; sso:SSO0002; -.
DR PATRIC; fig|273057.12.peg.3; -.
DR eggNOG; arCOG00020; Archaea.
DR HOGENOM; CLU_035788_0_0_2; -.
DR InParanoid; Q981E3; -.
DR PhylomeDB; Q981E3; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008902; F:hydroxymethylpyrimidine kinase activity; IBA:GO_Central.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IBA:GO_Central.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AAK40369.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001974};
KW Transferase {ECO:0000313|EMBL:AAK40369.1}.
FT DOMAIN 14..250
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 400 AA; 43746 MW; 166AB5C6B65E4B3A CRC64;
MHTRPVVATI AGSDSGGGAG LQADLKTFSA LGVFGTTIIT GLTAQNTRTV TKVLEIPLDF
IEAQFDAVCL DLHPTHAKTG MLASGKVVEL VLRKIREYNI KLVLDPVMVA KSGSLLVTED
ISEQIKKAMK EAIISTPNRY EAEIINKTKI NSQDDVIKAA REIYSKYGNV VVKGFNGVDY
AIIDGEEIEL KGDYISTKNT HGSGDVFSAS ITAYLALGYK LKDALIRAKK FATMTVKYGL
DLGGGYGPVD PFAPIESIVK REEGRNQLEN LLWYLESNLN VILKLINDTS KVNVAYMTKY
NDVLSLAGGL IKYLDKLKID GPILNNVNNE ITRIMRETPD EKIGILLPFT DKILDAAEKG
KIKLNKSGIN GDAILRDNMV LIIAKDKDEL IRKLKEVAIG
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