ID Q98207_MCV1 Unreviewed; 1004 AA.
AC Q98207;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 01-FEB-1997, sequence version 1.
DT 24-JAN-2024, entry version 114.
DE RecName: Full=DNA polymerase {ECO:0000256|ARBA:ARBA00015749, ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU000442};
GN Name=MC039L {ECO:0000313|EMBL:AAC55167.1};
OS Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus;
OC Molluscum contagiosum virus.
OX NCBI_TaxID=10280 {ECO:0000313|EMBL:AAC55167.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAC55167.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT host response-evasion genes.";
RL Science 273:813-816(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; U60315; AAC55167.1; -; Genomic_DNA.
DR PIR; T30641; T30641.
DR RefSeq; NP_043990.1; NC_001731.1.
DR SMR; Q98207; -.
DR GeneID; 1487060; -.
DR KEGG; vg:1487060; -.
DR OrthoDB; 165at10239; -.
DR Proteomes; UP000000869; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR013617; DNA-dir_DNA_pol_B_vir_insert.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR013660; DNApol_B_exo_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF08408; DNA_pol_B_3; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF08452; DNAP_B_exo_N; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000000869};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 1..22
FT /note="DNA polymerase B exonuclease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08452"
FT DOMAIN 109..344
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 345..472
FT /note="DNA-directed DNA polymerase family B viral insert"
FT /evidence="ECO:0000259|Pfam:PF08408"
FT DOMAIN 486..984
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 1004 AA; 115103 MW; 050EBD03FE967517 CRC64;
MEIRCLNWFE ARGEERALYL KAKTRAGDTL FVRFPHYYYY VVDGGTLSTL APPPRAASAL
GEFELACIDE TLARADALHA PTRPRSQLWL LEEAQPRQIA GALLAEFMHI TWFFLRNEIE
PNGCYRVPDA ELEPVCARCF HCAAPRRAFA TRVPLFEVTH TYLFFDIECQ FDKKFPSVFS
NPVSHISFCY VDRLGTEVRF SLLNSDLLSE DSLRGCRRIA TPDEFALEPG VTFCSEVVLL
QLTKRLLERH FDFIVTFNGN NFDIRYVSNR LQLLTQSSVC FRLPDQREPV KLVIYERSLA
SHRGAGGMAN TSFHVNNNNG TIFFDLYTFI QKAERLDSYK LDSISKNVFH CRARVLDAGA
GECTLAGGPD ANAEDRLRLF CEVLQTGNYV TLDTVHVCRI LGKRFFEHGF ALRVRCAESY
APGSLCELAF GKDDVDLREL YRHYSLAAAL EMERYCMHDA CLCKYLWSYY RVPSKIDAAA
ATYLLPQCLA LEYRASTLIK GPLLRLMLRE RVVYVRTQEP ARYTYGGGKV FLPRQKLFDT
NVMVFDYNSL YPNVCIFGNL SPETLVGVVA NAHRLDAEIN MQELRRRFPE PAFLHVLCEA
RARDGYSEIA VFDRRRQGII PKLLGTFMEQ RARYKALMRA ASSGLERTLY DSMQYVYKVV
ANSVYGLMGF YNSSLYSYSS AKCCTTIGRV MITYLDRVVD GATLCAGVLR LAAEPRNPLL
ASAPPRARDV DVSAALGHEL ELRFRSVYGD TDSIFLELNL REVQTTLAVA RTLERVLNEH
VLFENFRVEF EAIYQNLILQ SKKKYSTTKY AADHRAGDAP EHVSKGTSET RRDVSRFHKL
MISRYKAQLV ALLAEARLSS RQVCIEMLRS LEVDLFAEFA ARAQPLEMFL LSRMHHRNYK
APDNPNVELV NRYNRENLEP IELGERYYYA YVCASELPWQ LAVANVRNHE RIVDASYVLP
ERERVFYEIY FRRLATELVN LLDNKPLCAE FFTRLFGVRP VFSN
//
