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Database: UniProt
Entry: Q98213_MCV1
LinkDB: Q98213_MCV1
Original site: Q98213_MCV1 
ID   Q98213_MCV1             Unreviewed;        72 AA.
AC   Q98213;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   12-AUG-2020, entry version 51.
DE   SubName: Full=MC045 {ECO:0000313|EMBL:AQY16792.1};
DE   SubName: Full=MC045L {ECO:0000313|EMBL:AAC55173.1};
GN   Name=MC045L {ECO:0000313|EMBL:AAC55173.1};
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280 {ECO:0000313|Proteomes:UP000000869};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAC55173.1, ECO:0000313|Proteomes:UP000000869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
RN   [2] {ECO:0000313|EMBL:AQY16792.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Madrid 2016_3 {ECO:0000313|EMBL:AQY16792.1}, Madrid 2016_6
RC   {ECO:0000313|EMBL:AQY16972.1}, and Madrid 2016_7
RC   {ECO:0000313|EMBL:AQY17152.1};
RA   Lopez-Bueno A., Parras-Molto M., Lopez-Barrantes O., Belda S., Alejo A.;
RT   "Recombination events and variability among full-length genomes of co-
RT   circulating molluscum contagiosum virus subtypes 1 and 2.";
RL   J. Gen. Virol. 0:0-0(2017).
RN   [3] {ECO:0000313|EMBL:AYO87504.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MCV1_MB100 {ECO:0000313|EMBL:AYO87504.1}, MCV1_MC340
RC   {ECO:0000313|EMBL:AYO88363.1}, MCV1_MC343
RC   {ECO:0000313|EMBL:AYO88539.1}, MCV1_MC349
RC   {ECO:0000313|EMBL:AYO88716.1}, and MCV1_MC505
RC   {ECO:0000313|EMBL:AYO88893.1};
RA   Zorec T., Kutnjak D., Hosnjak L., Kusar B., Trcko K., Kocjan B., Li Y.,
RA   Krizmaric M., Miljkovic J., Ravnikar M., Poljak M.;
RT   "New Insights into the Evolutionary and Genomic Landscape of Molluscum
RT   Contagiosum Virus (MCV) based on Nine MCV1 and Six MCV2 Complete Genome
RT   Sequences.";
RL   Viruses 10:586-586(2018).
RN   [4] {ECO:0000313|EMBL:AYO87504.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MCV1_MB100 {ECO:0000313|EMBL:AYO87504.1}, MCV1_MC340
RC   {ECO:0000313|EMBL:AYO88363.1}, MCV1_MC343
RC   {ECO:0000313|EMBL:AYO88539.1}, MCV1_MC349
RC   {ECO:0000313|EMBL:AYO88716.1}, and MCV1_MC505
RC   {ECO:0000313|EMBL:AYO88893.1};
RA   Zorec T.M., Hosnjak L., Kutnjak D., Kusar B., Trcko K., Kocjan B.J., Li Y.,
RA   Krizmaric M., Miljkovic J., Ravnikar M., Poljak M.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Late protein which probably plays a role in virus entry into
CC       the host cell. {ECO:0000256|ARBA:ARBA00004101}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004381}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004381}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I2 family.
CC       {ECO:0000256|ARBA:ARBA00007048}.
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DR   EMBL; U60315; AAC55173.1; -; Genomic_DNA.
DR   EMBL; KY040275; AQY16792.1; -; Genomic_DNA.
DR   EMBL; KY040276; AQY16972.1; -; Genomic_DNA.
DR   EMBL; KY040277; AQY17152.1; -; Genomic_DNA.
DR   EMBL; MH320547; AYO87504.1; -; Genomic_DNA.
DR   EMBL; MH320552; AYO88363.1; -; Genomic_DNA.
DR   EMBL; MH320553; AYO88539.1; -; Genomic_DNA.
DR   EMBL; MH320554; AYO88716.1; -; Genomic_DNA.
DR   EMBL; MH320555; AYO88893.1; -; Genomic_DNA.
DR   PIR; T30647; T30647.
DR   RefSeq; NP_043996.1; NC_001731.1.
DR   GeneID; 1487066; -.
DR   KEGG; vg:1487066; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009175; Poxvirus_I2.
DR   Pfam; PF12575; Pox_EPC_I2-L1; 1.
DR   PIRSF; PIRSF003766; VAC_I2L; 1.
PE   3: Inferred from homology;
KW   Late protein {ECO:0000256|ARBA:ARBA00022921};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000869};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00022595}.
FT   TRANSMEM        47..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   72 AA;  8205 MW;  40C8714F009E8DD4 CRC64;
     MERLYAGIFG VFMTTPEDDF EEFLEVVQAV LTDSPRAARR APRAQSLLLF VLFAALLAAI
     LLFLYLKLAR RK
//
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