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Database: UniProt
Entry: Q98823
LinkDB: Q98823
Original site: Q98823 
ID   Q98823_HHV8             Unreviewed;       204 AA.
AC   Q98823;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   07-OCT-2020, entry version 103.
DE   SubName: Full=Interleukin-6 homolog {ECO:0000313|EMBL:AAB18244.1};
DE   Flags: Fragment;
GN   Name=vIL-6 {ECO:0000313|EMBL:AAB18244.1};
OS   Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=37296 {ECO:0000313|EMBL:AAB18244.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAB18244.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Neipel F., Albrecht J.-C., Ensser A., Huang Y.-Q., Li J.J.,
RA   Friedman-Kien A.-E., Fleckenstein B.;
RT   "Human herpesvirus 8 encodes a homologue of interleukin-6.";
RL   J. Virol. 0:0-0(1996).
RN   [2] {ECO:0000213|PDB:1I1R}
RP   X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 24-204, AND DISULFIDE BONDS.
RX   PubMed=11251120; DOI=10.1126/science.1058308;
RA   Chow D., He X., Snow A.L., Rose-John S., Garcia K.C.;
RT   "Structure of an extracellular gp130 cytokine receptor signaling complex.";
RL   Science 291:2150-2155(2001).
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC       {ECO:0000256|ARBA:ARBA00007432}.
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DR   EMBL; U73655; AAB18244.1; -; Genomic_DNA.
DR   PDB; 1I1R; X-ray; 2.40 A; B=24-204.
DR   PDBsum; 1I1R; -.
DR   SMR; Q98823; -.
DR   IntAct; Q98823; 1.
DR   EvolutionaryTrace; Q98823; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003574; IL-6.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   PANTHER; PTHR10511:SF3; PTHR10511:SF3; 1.
DR   Pfam; PF00489; IL6; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:1I1R};
KW   Evasion of host immunity by viral interleukin-like protein
KW   {ECO:0000256|ARBA:ARBA00022938};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023280};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT   DISULFID        54..60
FT                   /evidence="ECO:0000213|PDB:1I1R"
FT   DISULFID        83..93
FT                   /evidence="ECO:0000213|PDB:1I1R"
FT   NON_TER         204
FT                   /evidence="ECO:0000313|EMBL:AAB18244.1"
SQ   SEQUENCE   204 AA;  23408 MW;  1CA7772A0EDC05EB CRC64;
     MCWFKLWSLL LVGSLLVSGT RGKLPDAPEF EKDLLIQRLN WMLWVIDECF RDLCYRTGIC
     KGILEPAAIF HLKLPAINDT DHCGLIGFNE TSCLKKLADG FFEFEVLFKF LTTEFGKSVI
     NVDVMELLTK TLGWDIQEEL NKLTKTHYSP PKFDRGLLGR LQGLKYWVRH FASFYVLSAM
     EKFAGQAVRV LDSIPDVTPD VHDK
//
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