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Database: UniProt
Entry: Q98F05
LinkDB: Q98F05
Original site: Q98F05 
ID   ALR2_RHILO              Reviewed;         381 AA.
AC   Q98F05;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   16-JAN-2019, entry version 98.
DE   RecName: Full=Alanine racemase, catabolic;
DE            EC=5.1.1.1;
GN   Name=dadB; OrderedLocusNames=mll3997;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T.,
RA   Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Mochizuki Y., Nakayama S., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: Isomerizes L-alanine to D-alanine which is then oxidized
CC       to pyruvate by DadA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249,
CC         ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=5.1.1.1;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the alanine racemase family. {ECO:0000305}.
DR   EMBL; BA000012; BAB50762.1; -; Genomic_DNA.
DR   RefSeq; WP_010912105.1; NC_002678.2.
DR   ProteinModelPortal; Q98F05; -.
DR   SMR; Q98F05; -.
DR   STRING; 266835.mll3997; -.
DR   PRIDE; Q98F05; -.
DR   EnsemblBacteria; BAB50762; BAB50762; BAB50762.
DR   KEGG; mlo:mll3997; -.
DR   PATRIC; fig|266835.9.peg.3173; -.
DR   eggNOG; ENOG4105CJ4; Bacteria.
DR   eggNOG; COG0787; LUCA.
DR   HOGENOM; HOG000031445; -.
DR   KO; K01775; -.
DR   OMA; VEILFIM; -.
DR   OrthoDB; 859043at2; -.
DR   BioCyc; MLOT266835:G1G20-3175-MONOMER; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0008784; F:alanine racemase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006522; P:alanine metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.37.10; -; 1.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_01201; Ala_racemase; 1.
DR   InterPro; IPR000821; Ala_racemase.
DR   InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR   InterPro; IPR011079; Ala_racemase_C.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR020622; Ala_racemase_pyridoxalP-BS.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   Pfam; PF00842; Ala_racemase_C; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PRINTS; PR00992; ALARACEMASE.
DR   SMART; SM01005; Ala_racemase_C; 1.
DR   SUPFAM; SSF50621; SSF50621; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00492; alr; 1.
DR   PROSITE; PS00395; ALANINE_RACEMASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN         1    381       Alanine racemase, catabolic.
FT                                /FTId=PRO_0000114552.
FT   ACT_SITE     55     55       Proton acceptor; specific for D-alanine.
FT                                {ECO:0000250}.
FT   ACT_SITE    276    276       Proton acceptor; specific for L-alanine.
FT                                {ECO:0000250}.
FT   BINDING     154    154       Substrate. {ECO:0000250}.
FT   BINDING     322    322       Substrate; via amide nitrogen.
FT                                {ECO:0000250}.
FT   MOD_RES      55     55       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000250}.
SQ   SEQUENCE   381 AA;  39784 MW;  22B0C7837380066F CRC64;
     MNDAVNPTAA KTVTGWPVSE AAAGAILTID LGAIRENYRR LKALLGGVHC AGVVKANGYG
     LGAAKVAAAL TREGCDIFFV ALLAEGIALR KAVGTGPDIY VLNGLPPGSE PEAVAAGLCA
     VINSGAQLKA WRAAVHDAGR RLPAAIQVDS GMSRLGMAPA EVEALAGDSS AFDGIDIKYV
     MSHLACADEP RHPANEQQRL AFERLRAMLP RAPASLANSS GIFLGPSYHH DLARPGAALY
     GINPTPGEPN PMLPVVWLQA KVAQTRRIEK GAGIGYGHSY HADGPLSLAT ISFGYADGWL
     RRSASAAWFE GVRLPFLGRV SMDSIILDIS ALPPGRLREG DLVELLGPSQ SVDDAAGHAG
     TIGYEILASL GPRFHRHYVG G
//
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