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Database: UniProt
Entry: Q98SM3
LinkDB: Q98SM3
Original site: Q98SM3 
ID   EZH2A_XENLA             Reviewed;         748 AA.
AC   Q98SM3; Q5XH80;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JAN-2019, entry version 77.
DE   RecName: Full=Histone-lysine N-methyltransferase EZH2;
DE            EC=2.1.1.43;
DE   AltName: Full=Enhancer of zeste homolog 2-A;
GN   Name=ezh2-a; Synonyms=xez;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RX   PubMed=11287189; DOI=10.1016/S0925-4773(01)00304-5;
RA   Barnett M.W., Seville R.A., Nijjar S., Old R.W., Jones E.A.;
RT   "Xenopus Enhancer of Zeste (XEZ); an anteriorly restricted polycomb
RT   gene with a role in neural patterning.";
RL   Mech. Dev. 102:157-167(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein (By similarity). Catalytic
CC       subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and
CC       'Lys-27' of histone H3, leading to transcriptional repression of
CC       the affected target gene (By similarity). May repress
CC       transcription of the egr2 and en2 genes. May regulate the
CC       circadian clock via histone methylation at the promoter of the
CC       circadian genes (By similarity). {ECO:0000250|UniProtKB:Q61188,
CC       ECO:0000269|PubMed:11287189}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Does not appear to be maternally expressed.
CC       Zygotic expression begins at late blastula, increases at mid and
CC       late gastrula, and peaks in the early neurula. Expression is
CC       restricted to the anterior nervous system.
CC       {ECO:0000269|PubMed:11287189}.
CC   -!- INDUCTION: Induced by inhibition of BMP signaling.
CC       {ECO:0000269|PubMed:11287189}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. EZ subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
DR   EMBL; AF351126; AAK30208.1; -; mRNA.
DR   EMBL; BC084193; AAH84193.1; -; mRNA.
DR   RefSeq; NP_001083886.1; NM_001090417.1.
DR   RefSeq; XP_018121884.1; XM_018266395.1.
DR   UniGene; Xl.19136; -.
DR   ProteinModelPortal; Q98SM3; -.
DR   PRIDE; Q98SM3; -.
DR   GeneID; 399174; -.
DR   KEGG; xla:399174; -.
DR   CTD; 399174; -.
DR   Xenbase; XB-GENE-956220; ezh2.
DR   HOVERGEN; HBG002453; -.
DR   KO; K11430; -.
DR   OrthoDB; 875190at2759; -.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0045814; P:negative regulation of gene expression, epigenetic; ISS:UniProtKB.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR021654; EZH1/EZH2.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR   Pfam; PF11616; EZH2_WD-Binding; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM01114; CXC; 1.
DR   SMART; SM00717; SANT; 2.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51633; CXC; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Chromatin regulator; Methyltransferase; Nucleus;
KW   Repressor; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN         1    748       Histone-lysine N-methyltransferase EZH2.
FT                                /FTId=PRO_0000345428.
FT   DOMAIN      505    607       CXC. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00970}.
FT   DOMAIN      614    729       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   COMPBIAS    183    211       Asp-rich.
FT   COMPBIAS    525    590       Cys-rich.
FT   CONFLICT     25     25       A -> R (in Ref. 2; AAH84193).
FT                                {ECO:0000305}.
FT   CONFLICT     31     31       K -> R (in Ref. 2; AAH84193).
FT                                {ECO:0000305}.
FT   CONFLICT    290    290       P -> R (in Ref. 2; AAH84193).
FT                                {ECO:0000305}.
SQ   SEQUENCE   748 AA;  85383 MW;  8618F615B348C46C CRC64;
     MGQTGKKSEK GPVCWRKRVK SEYMALRQLK KFRRADEVKS MFNTNRQKIM ERTEILNQEW
     KQRRIQPVHI MTTVSSLRGT RECSVTSDLD FPKQVIPLKT LTAVASVPIM YSWSPLQQNF
     MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALAQ
     YSDYEDDEDG DDNQDDEQDD TAKDQDDNME DKETQPLRKF PSDKIFEAIS SMFPDKGTSE
     ELKEKYKELT EQQLPGALPP ECTPNIDGPN AKSVQREQSL HSFHTLFCRP CFKYDCFLHP
     FHATPNTYKR KNNEAANDGK PCGPHCYQLL EGAREFAAAL TAERIKTPPK RPSGRRRGRL
     PNNTSRPSTP TVNVSEAKDT DSDREAGTET GGESNDKEEE EKKDETSSSS EANSRCQTPI
     KMKPNIEPPE NVEWSGAEAS LFRVLIGTYY DNFCAIARLI GTKTCRQVYE FRVKESSIIS
     PVIAEDVDTP PRKKKRKHRL WAAHCRKIQL KKDGSSNHVY NYQPCDHPRQ PCDSSCPCVI
     AQNFCEKFCQ CSSECQNRFP GCRCKAQCNT KQCPCYLAVR ECDPDLCLTC GAADHWDSKN
     VSCKNCSIQR GSKKHLLLAP SDVAGWGIFI NDTVQKNEFI SEYCGEIISQ DEADRRGKVY
     DKYMCSFLFN LNNDFVVDAT RKGNKIRFAN HSVNPNCYAK VMMVNGDHRI GIFAKRAIQT
     GEELFFDYRY SQADALKYVG IEREMEIP
//
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