GenomeNet

Database: UniProt
Entry: Q99PT0
LinkDB: Q99PT0
Original site: Q99PT0 
ID   DDX52_RAT               Reviewed;         598 AA.
AC   Q99PT0;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-OCT-2019, entry version 118.
DE   RecName: Full=Probable ATP-dependent RNA helicase DDX52;
DE            EC=3.6.4.13;
DE   AltName: Full=ATP-dependent RNA helicase ROK1-like;
DE            Short=rROK1L;
DE   AltName: Full=DEAD box protein 52;
GN   Name=Ddx52; Synonyms=Rok1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Li W., Suzuki T.;
RT   "Identification of a novel ROK1-like protein in rat brain.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX52/ROK1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AB055628; BAB32441.1; -; mRNA.
DR   RefSeq; NP_445977.1; NM_053525.1.
DR   SMR; Q99PT0; -.
DR   STRING; 10116.ENSRNOP00000003600; -.
DR   CarbonylDB; Q99PT0; -.
DR   PaxDb; Q99PT0; -.
DR   PRIDE; Q99PT0; -.
DR   Ensembl; ENSRNOT00000003600; ENSRNOP00000003600; ENSRNOG00000002612.
DR   GeneID; 85432; -.
DR   KEGG; rno:85432; -.
DR   CTD; 11056; -.
DR   RGD; 621743; Ddx52.
DR   eggNOG; KOG0344; Eukaryota.
DR   eggNOG; ENOG410XQS8; LUCA.
DR   GeneTree; ENSGT00550000074863; -.
DR   HOGENOM; HOG000242486; -.
DR   InParanoid; Q99PT0; -.
DR   KO; K14779; -.
DR   OMA; ICTTPRF; -.
DR   OrthoDB; 400908at2759; -.
DR   PhylomeDB; Q99PT0; -.
DR   TreeFam; TF314448; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q99PT0; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000002612; Expressed in 10 organ(s), highest expression level in spleen.
DR   Genevisible; Q99PT0; RN.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; NAS:RGD.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; TAS:RGD.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   RNA-binding.
FT   CHAIN         1    598       Probable ATP-dependent RNA helicase
FT                                DDX52.
FT                                /FTId=PRO_0000055062.
FT   DOMAIN      197    375       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      386    547       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     210    217       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       166    194       Q motif.
FT   MOTIF       319    322       DEAD box.
FT   COMPBIAS     86     92       Poly-Lys.
FT   MOD_RES      15     15       N6-acetyllysine.
FT                                {ECO:0000250|UniProtKB:Q9Y2R4}.
FT   MOD_RES      39     39       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9Y2R4}.
SQ   SEQUENCE   598 AA;  67240 MW;  B9E818EA6B144425 CRC64;
     MDSYDLFRRL GAGAKFDVKR FSADATRFQV GKRKFGSDSS ETVKGLDFFG NKKSVSDECG
     GLQTQQELQN EETTEGGLLE RSKEPKKKKR KKMTADVPAQ EDLDGTIQWT SSVEAKLQDK
     KANGEKKLTS EKLEHLRKEK INFFRNKHKI HVQGTDLPDP IATFQQLDQE YKISPRLLQN
     ILDAGFQVPT PIQMQAIPVM LHGRELLASA PTGSGKTLAF SIPILMQLKQ PTNKGFRALV
     ISPTRELASQ IHRELIKISE GTGFRIHMIH KAAIAAKKFG PKSSKKFDIL VTTPNRLIYL
     LKQEPPGIDL TSVEWLVVDE SDKLFEDGKT GFRDQLASIF LACTSPKVRR AMFSATFAYD
     VEQWCKLNLD NIVSVSIGAR NSAVETVEQE LLFVGSETGK LLAMRELVKK GFNPPVLVFV
     QSIERAKELF HELIYEGINV DVIHAERTQQ QRDNTVHSFR AGKIWVLICT ALLARGIDFK
     GVNLVINYDF PTSSVEYIHR IGRTGRAGNR GKAVTFFTED DKPLLRSVAN VIQQAGCPVP
     EYIKGFQKLL SKQKKKMIKK PLERESISTT PKYFLEQAKQ KKVAGQNSKK KETLKGKS
//
DBGET integrated database retrieval system