ID Q99QQ6_STRCO Unreviewed; 238 AA.
AC Q99QQ6; Q7B0B1;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=DmdR2 protein {ECO:0000313|EMBL:CAC28071.1};
DE SubName: Full=Iron dependent repressor {ECO:0000313|EMBL:CAC32357.1};
GN Name=desR2 {ECO:0000313|EMBL:CAC32357.1};
GN Synonyms=dmdR2 {ECO:0000313|EMBL:CAC28071.1};
GN OrderedLocusNames=SCO4017 {ECO:0000313|EMBL:CAC32357.1};
GN ORFNames=2SC10A7.21c {ECO:0000313|EMBL:CAC32357.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC32357.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC28071.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC28071.1};
RA Flores Delgado F.J.;
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAC28071.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC28071.1};
RA Flores F.J.;
RT "Cloning and analysis of dmdR genes.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAC32357.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A3 {ECO:0000313|EMBL:CAC32357.1}, and ATCC BAA-471 / A3(2) /
RC M145 {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC {ECO:0000256|ARBA:ARBA00007871}.
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DR EMBL; AJ271798; CAC28071.1; -; Genomic_DNA.
DR EMBL; AL939118; CAC32357.1; -; Genomic_DNA.
DR RefSeq; NP_628199.1; NC_003888.3.
DR RefSeq; WP_011029385.1; NZ_VNID01000032.1.
DR AlphaFoldDB; Q99QQ6; -.
DR STRING; 100226.gene:17761647; -.
DR PaxDb; 100226-SCO4017; -.
DR PATRIC; fig|100226.15.peg.4080; -.
DR eggNOG; COG1321; Bacteria.
DR HOGENOM; CLU_069532_0_0_11; -.
DR OrthoDB; 4300241at2; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 2.30.30.90; -; 1.
DR Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR007167; Fe-transptr_FeoA.
DR InterPro; IPR001367; Fe_dep_repressor.
DR InterPro; IPR036421; Fe_dep_repressor_sf.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR022687; HTH_DTXR.
DR InterPro; IPR022689; Iron_dep_repressor.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR PANTHER; PTHR33238:SF10; IRON-DEPENDENT REPRESSOR IDER; 1.
DR Pfam; PF02742; Fe_dep_repr_C; 1.
DR Pfam; PF01325; Fe_dep_repress; 1.
DR Pfam; PF04023; FeoA; 1.
DR SMART; SM00899; FeoA; 1.
DR SMART; SM00529; HTH_DTXR; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50944; HTH_DTXR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..65
FT /note="HTH dtxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50944"
FT REGION 128..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 238 AA; 25603 MW; 07DE5948A825F661 CRC64;
MSRLIDTTEM YLRTVLELEE EGVVPLRARI AEHLDQSGPT VSQTVARMER DGLLRIAADR
HLELTDTGRR LATRVMRKHR LAECLLVDVI GLEWEQVHAE ACRWEHVMSE AVERRLLRLL
RHPTESPYGN PIPGLEELGG ANPAAPRPSA PAPAPAAGST VSLGDLLPGP DGVSAVVRRI
GEPVQADGGL LVTLRRAGVR PGAVVRVTPW PGGVTVGSGG RTARLPARTA AHVFVAPL
//
