GenomeNet

Database: UniProt
Entry: Q99RW8
LinkDB: Q99RW8
Original site: Q99RW8 
ID   Y2305_STAAM             Reviewed;         317 AA.
AC   Q99RW8;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   20-JUN-2018, entry version 107.
DE   RecName: Full=Putative 2-hydroxyacid dehydrogenase SAV2305;
DE            EC=1.1.1.-;
GN   OrderedLocusNames=SAV2305;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA   Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA   Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA   Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA   Ogasawara N., Hayashi H., Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus
RT   aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; BA000017; BAB58467.1; -; Genomic_DNA.
DR   RefSeq; WP_000417018.1; NC_002758.2.
DR   ProteinModelPortal; Q99RW8; -.
DR   SMR; Q99RW8; -.
DR   STRING; 158878.SAV2305; -.
DR   World-2DPAGE; 0002:Q99RW8; -.
DR   PaxDb; Q99RW8; -.
DR   EnsemblBacteria; BAB58467; BAB58467; SAV2305.
DR   KEGG; sav:SAV2305; -.
DR   eggNOG; ENOG4105C5I; Bacteria.
DR   eggNOG; COG1052; LUCA.
DR   OMA; KWIAHNG; -.
DR   PhylomeDB; Q99RW8; -.
DR   BioCyc; SAUR158878:SAV_RS12570-MONOMER; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    317       Putative 2-hydroxyacid dehydrogenase
FT                                SAV2305.
FT                                /FTId=PRO_0000312184.
FT   NP_BIND     155    156       NAD. {ECO:0000250}.
FT   NP_BIND     234    236       NAD. {ECO:0000250}.
FT   NP_BIND     283    286       NAD. {ECO:0000250}.
FT   ACT_SITE    236    236       {ECO:0000250}.
FT   ACT_SITE    265    265       {ECO:0000250}.
FT   ACT_SITE    283    283       Proton donor. {ECO:0000250}.
FT   BINDING     260    260       NAD. {ECO:0000250}.
SQ   SEQUENCE   317 AA;  34703 MW;  5BE0CFCCC2CAB5B5 CRC64;
     MEKVYVAGAI PEVGLKLLQE HFEVEMYEGK GLVDKDTLIK GVKNATALIS LLSTNVDKDV
     IDAGKDLKII ANYGAGFNNI DIEYAREKSI DVTNTPKAST NATADLTIGL VLAVARRIVE
     GDQLSRTTGF DGWAPLFFRG REVSGKTIGI IGLGEIGSAV ARRARAFDMD VLYTGPNRKE
     EKEREIGAKY VDLDTLLKNA DFITINAAYN PKMHHLIDTE QFKMMKSTVY LINASRGPIV
     HEQALVQALK DNEIEGAALD VYEFEPDITD DLKSLNNVVL TPHIGNATFE ARDMMSKIVA
     NAAISAVQGE KPQFVVN
//
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