ID Q99YL5_STRP1 Unreviewed; 384 AA.
AC Q99YL5; Q48XF6;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 24-JAN-2024, entry version 156.
DE RecName: Full=THUMP domain-containing protein {ECO:0000259|PROSITE:PS51165};
GN OrderedLocusNames=SPy_1644 {ECO:0000313|EMBL:AAK34412.1};
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447 {ECO:0000313|EMBL:AAK34412.1, ECO:0000313|Proteomes:UP000000750};
RN [1] {ECO:0000313|EMBL:AAK34412.1, ECO:0000313|Proteomes:UP000000750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1
RC {ECO:0000313|Proteomes:UP000000750};
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Adjic D., Savic D., Savic G., Lyon K.,
RA Primeaux C., Sezate S.S., Surorov A.N., Kenton S., Lai H., Lin S., Qian Y.,
RA Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
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DR EMBL; AE004092; AAK34412.1; -; Genomic_DNA.
DR RefSeq; NP_269691.1; NC_002737.2.
DR AlphaFoldDB; Q99YL5; -.
DR PaxDb; 1314-HKU360_01400; -.
DR KEGG; spy:SPy_1644; -.
DR PATRIC; fig|160490.10.peg.1433; -.
DR HOGENOM; CLU_032119_3_1_9; -.
DR OMA; GFMYKAN; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR47313; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L; 1.
DR PANTHER; PTHR47313:SF1; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000000750};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 45..159
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 384 AA; 43232 MW; 88323D9844A0A0EC CRC64;
MKETFRLVAT AAAGLEAVVG KEVRALGFDC QVENGKVYFE GDVEAIVKTN LWLRAADRIK
IIVGQFPART FEELFQGVFA LDWENYLPLG AKFPISKAKC VKSKLHNEPS VQAITKKAVV
KKLQKHFHRP EGVPLQEVGS TFNIEVSILK DQATIMIDTT GSSLFKRGYR VQKGGAPIKE
NMAAAILALS NWFPDKPLVD PTCGSGTFCI EAAMIGMNIA PGFNRSFAFE EWSWVDKDMV
QQVRDDAEQE ANYEIELDIS GFDIDGRMIE IAKSNAEEAG LSDVITFKQM RLQDFRTDKV
NGVVISNPPY GERLLDDKAV DILYNEMGQT FAPLKTWSKF ILTSDELFEL KYGQKADKKR
KLYNGTLKVD LYQFYGERVK RHLI
//