ID   Q99YW6_STRP1            Unreviewed;       760 AA.
AC   Q99YW6; Q48XR7;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 146.
DE   SubName: Full=ATP-dependent protease {ECO:0000313|EMBL:AAK34306.1};
GN   Name=clpE {ECO:0000313|EMBL:AAK34306.1};
GN   OrderedLocusNames=SPy_1509 {ECO:0000313|EMBL:AAK34306.1};
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447 {ECO:0000313|EMBL:AAK34306.1, ECO:0000313|Proteomes:UP000000750};
RN   [1] {ECO:0000313|EMBL:AAK34306.1, ECO:0000313|Proteomes:UP000000750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1
RC   {ECO:0000313|Proteomes:UP000000750};
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Adjic D., Savic D., Savic G., Lyon K.,
RA   Primeaux C., Sezate S.S., Surorov A.N., Kenton S., Lai H., Lin S., Qian Y.,
RA   Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; AE004092; AAK34306.1; -; Genomic_DNA.
DR   RefSeq; NP_269585.1; NC_002737.2.
DR   AlphaFoldDB; Q99YW6; -.
DR   PaxDb; 1314-HKU360_01282; -.
DR   KEGG; spy:SPy_1509; -.
DR   PATRIC; fig|160490.10.peg.1317; -.
DR   HOGENOM; CLU_005070_4_3_9; -.
DR   OMA; MESEPAK; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Hydrolase {ECO:0000313|EMBL:AAK34306.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:AAK34306.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000750}.
FT   DOMAIN          372..407
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   REGION          77..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   760 AA;  84733 MW;  5959A06AE781FA61 CRC64;
     MLCQNCNLNE STIHLYTSVN GKQRQVDLCQ NCYQIMKSDP ANSILNGLTP GYRAQDRSTS
     PFFDDFFGDL NNFRAFGNLP NTPPTQAGQN GNGGGRYGGN YNGQRPAQPQ TPNQQAKGLL
     EEFGINVTDI ARNGNIDPVI GRDEEITRVI EILNRRTKNN PVLIGEPGVG KTAVVEGLAQ
     KIIDGTVPQK LQGKQVIRLD VVSLVQGTGI RGQFEERMQK LMEEIRNRKD VILFIDEIHE
     IVGAGSAGDG NMDAGNILKP ALARGELQLV GATTLNEYRI IEKDAALERR MQPVKVDEPS
     VEETITILKG IQPKYEDYHH VKYSPAAIEA AAHLSNRYIQ DRFLPDKAID LLDEAGSKMN
     LTLNFVDPKE IDKRLIEAEN LKAQATRDED YERAAYFRDQ ITKYKEMQAQ KVDEQDIPII
     TEKTIEAIVE QKTNIPVGDL KEKEQSQLVN LANDLKAHVI GQDDAVDKIA KAIRRNRVGL
     GTPNRPIGSF LFVGPTGVGK TELSKQLAIE LFGSTNNMIR FDMSEYMEKH AVAKLVGAPP
     GYIGYEEAGQ LTEQVRRNPY SLILLDEVEK AHPDVMHMFL QVLDDGRLTD GQGRTVSFKD
     TIIIMTSNAG TGKSEASVGF GAAREGRTSS VLGELSNFFS PEFMNRFDGI IEFKALSKEH
     LLHIVDLMLE DVNERLGYNG IHLDVTQKVK EKLVDLGYDP KMGARPLRRT IQDYIEDAIT
     DYYLEHPTEK QLRALMTNSE NITIKAVKEG DSFLNEESLD
//