ID Q99Z32_STRP1 Unreviewed; 259 AA.
AC Q99Z32; Q48XZ6;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=Formate dehydrogenase {ECO:0000313|EMBL:AAK34235.1};
DE EC=1.2.1.2 {ECO:0000313|EMBL:AAK34235.1};
GN OrderedLocusNames=SPy_1424 {ECO:0000313|EMBL:AAK34235.1};
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447 {ECO:0000313|EMBL:AAK34235.1, ECO:0000313|Proteomes:UP000000750};
RN [1] {ECO:0000313|EMBL:AAK34235.1, ECO:0000313|Proteomes:UP000000750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1
RC {ECO:0000313|Proteomes:UP000000750};
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Adjic D., Savic D., Savic G., Lyon K.,
RA Primeaux C., Sezate S.S., Surorov A.N., Kenton S., Lai H., Lin S., Qian Y.,
RA Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FNT transporter (TC 2.A.44) family.
CC {ECO:0000256|ARBA:ARBA00006470}.
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DR EMBL; AE004092; AAK34235.1; -; Genomic_DNA.
DR RefSeq; NP_269514.1; NC_002737.2.
DR AlphaFoldDB; Q99Z32; -.
DR PaxDb; 1314-HKU360_01195; -.
DR KEGG; spy:SPy_1424; -.
DR PATRIC; fig|160490.10.peg.1240; -.
DR HOGENOM; CLU_036896_1_1_9; -.
DR OMA; MIWFPIM; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000292; For/NO2_transpt.
DR InterPro; IPR024002; For/NO2_transpt_CS.
DR PANTHER; PTHR30520; FORMATE TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR30520:SF6; FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG); 1.
DR Pfam; PF01226; Form_Nir_trans; 1.
DR PROSITE; PS01005; FORMATE_NITRITE_TP_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:AAK34235.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000750};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 259 AA; 27755 MW; 5BA7BCEFDF177063 CRC64;
MKTPEQILEA TIHIGEHKVT KTFLAKSILG FIGGAMISLG YLLYVRIAAS GLETFGAFSS
IVGACAFPIG LIIILMAGGE LITGNMMAVS AALLAKKIKF SELAKNWLII TLFNVIGAVF
VAFVFGHFLG LTSAGIFKEE VIEVAHAKIA ASPLQALVSG IGCNWFVGLA LWLCYGANDA
AGKFLGTWFP VMTFVALGFQ HSVANAFVIP AAIFEGGATW LDFVTNFIFV YSGNIIGGAI
FVSFLYFKVY YHPQKSKTQ
//
