ID Q9A0C9_STRP1 Unreviewed; 419 AA.
AC Q9A0C9; Q48ZG0;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=Uracil permease {ECO:0000313|EMBL:AAK33762.1};
GN Name=pyrP {ECO:0000313|EMBL:AAK33762.1};
GN OrderedLocusNames=SPy_0831 {ECO:0000313|EMBL:AAK33762.1};
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447 {ECO:0000313|EMBL:AAK33762.1, ECO:0000313|Proteomes:UP000000750};
RN [1] {ECO:0000313|EMBL:AAK33762.1, ECO:0000313|Proteomes:UP000000750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1
RC {ECO:0000313|Proteomes:UP000000750};
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Adjic D., Savic D., Savic G., Lyon K.,
RA Primeaux C., Sezate S.S., Surorov A.N., Kenton S., Lai H., Lin S., Qian Y.,
RA Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; AE004092; AAK33762.1; -; Genomic_DNA.
DR RefSeq; NP_269041.1; NC_002737.2.
DR AlphaFoldDB; Q9A0C9; -.
DR PaxDb; 1314-HKU360_00654; -.
DR DNASU; 900998; -.
DR KEGG; spy:SPy_0831; -.
DR PATRIC; fig|160490.10.peg.709; -.
DR HOGENOM; CLU_017959_1_2_9; -.
DR OMA; FMEHIGD; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000750};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 419 AA; 44038 MW; 36CDE644F2F33BD5 CRC64;
MKDVIYDVEE VPKAGMLVGL SFQHLFAMFG ATVLVPILVG IDPSVALLSS GLGTLAHLSV
TKFKIPAYMG SSFAYIAAMQ LLMKTNGIGA VAQGAMTGGL VYLIVALIVK AIGNDWIDNI
LPPIVVGPIV MVIGLSLAST AVNDVMLKNG NYNLTYLVIG LVTLLSVIFF NIYGKGIVAI
VPLLLGLLVG YVVALLVGVL TGQEIVDFTN VAQAKWFSIP SVEIPFLTYG VKFYPSAILT
MAPIAFVTMT EHFGHIMVLN SLTKRDYFKD PGLEKTLTGD GFAQIIAGFL GAPPVTSYGE
NIGVMALNKI FSVYVIAGAA VIAALLSFIG KVSALIQSIP TPVIGGISVA LFGVIASSGL
KILIESKVDM DNKKNLLIAS VILVSGIGGL MLQVNGLQIS GVAFSTLLGI ILYQVLPEK
//
